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SMARTDIAGNOS SIGNED

Next generation sepsis diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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 SMARTDIAGNOS project word cloud

Explore the words cloud of the SMARTDIAGNOS project. It provides you a very rough idea of what is the project "SMARTDIAGNOS" about.

economic    enhanced    antibiotic    unlimited    spread    public    circumvent    reduce    profiling    precise    health    damages    tools    bacteria    pathogens    multiplex    automation    quantification    organs    patient    care    hence    biggest    device    supercritical    technologies    initial    human    dimentional    smartdiagnos    hour    mortality    delay    urgent    treatment    95    saf    array    shorten    acid    microstructure    therapy    mainly    fatal    99    shorter    single    arises    clinical    fungi    worldwide    microlens    direct    solid    issue    innovative    impaired    caused    blood    capability    simplifying    fast    outcome    intensive    infection    dna    selectivity    earlier    potentially    concentration    nucleic    tissues    3d    rapid    antimicrobial    stay    critical    unfortunately    extraction    resistance    accurate    appropriate    sepsis    incidence    circulation    time    combining    pcr    days    patients    greatest    multiplexing    raw    administered    10    sensitivity    body    fluorescence    integrating    50    detection    angle    amount    culture    diagnostic    streamlined    diagnosis    correct   

Project "SMARTDIAGNOS" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.smartdiagnos.eu
 Total cost 4˙797˙602 €
 EC max contribution 4˙027˙909 € (84%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2015
 Funding Scheme IA
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙393˙615.00
2    CUBE DX GMBH AT (ST VALENTIN) participant 721˙122.00
3    SCANDINAVIAN MICRO BIODEVICES APS DK (FARUM) participant 699˙953.00
4    UNIVERSITAT FUR WEITERBILDUNG KREMS AT (KREMS) participant 273˙550.00
5    TATAA BIOCENTER AB SE (GOTEBORG) participant 248˙624.00
6    HOGSKOLAN I SKOVDE SE (SKOVDE) participant 183˙500.00
7    UNIVERZITA KARLOVA CZ (PRAHA 1) participant 130˙000.00
8    DIN DEUTSCHES INSTITUT FUER NORMUNG E.V. DE (BERLIN) participant 128˙337.00
9    UNILABS AB SE (GOTEBORG) participant 126˙250.00
10    COPENHAGEN BUSINESS SCHOOL DK (FREDERIKSBERG) participant 122˙955.00

Map

 Project objective

Sepsis is a potentially fatal condition that arises when the body’s response to an infection damages its own tissues and organs. It is mainly caused by bacteria and fungi, which spread through the blood circulation. It is one of the biggest public health issue in the EU and worldwide due to its high incidence, mortality, human and economic cost. Early diagnosis is crucial to the management of sepsis, as every hour of delay of appropriate antibiotic therapy increases mortality by 5-10%. Unfortunately, sepsis diagnosis remains one of the greatest clinical challenges in critical care. Current diagnostic methods, including blood culture and different nucleic acid based multiplex technologies, are impaired by the significant time-delay of 1-2 days and/or low sensitivity of 30-50%. Hence there is an urgent need to develop new diagnostic tools that can provide more accurate and earlier sepsis diagnosis, so that patients with sepsis can be administered with rapid and correct initial antimicrobial treatment. The SMARTDIAGNOS project will advance sepsis diagnosis by simplifying clinical sample analysis methods and integrating the currently required numerous steps into a single streamlined device. This will be achieved by combining a number of innovative technologies: 1) 3-dimentional sample concentration to process large amount of raw sample; 2) direct PCR in the 3D microstructure to circumvent DNA extraction step; 3) solid-phase PCR to achieve unlimited multiplexing capability; 4) supercritical angle fluorescence (SAF) microlens array for enhanced fluorescence detection and precise quantification of sepsis-related pathogens. The SMARTDIAGNOS system will go beyond the state of the art for shorter time (1-3 h), higher sensitivity (95%), higher selectivity (99%), multiplexing capability, antimicrobial resistance profiling, and automation. Fast and correct sepsis diagnosis will improve patient outcome, shorten intensive care stay and thus reduce health costs.

 Publications

year authors and title journal last update
List of publications.
2017 Tran Quang Hung, Wai Hoe Chin, Yi Sun, Anders Wolff, Dang Duong Bang
A novel lab-on-chip platform with integrated solid phase PCR and Supercritical Angle Fluorescence (SAF) microlens array for highly sensitive and multiplexed pathogen detection
published pages: 217-223, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.11.028
Biosensors and Bioelectronics 90 2020-02-24
2018 Vivek Priy Dave, Tien Anh Ngo, Anna-Karin Pernestig, Diana Tilevik, Krishna Kant, Trieu Nguyen, Anders Wolff, Dang Duong Bang
MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics
published pages: , ISSN: 0023-6837, DOI: 10.1038/s41374-018-0143-3
Laboratory Investigation 2020-02-24
2019 Aaydha C. Vinayaka, Tien A. Ngo, Krishna Kant, Pia Engelsmann, Vivek P. Dave, Mohammad-Ali Shahbazi, Anders Wolff, Dang D. Bang
Rapid detection of Salmonella enterica in food samples by a novel approach with combination of sample concentration and direct PCR
published pages: 224-230, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.09.078
Biosensors and Bioelectronics 129 2020-02-24
2018 Krishna Kant, Mohammad-Ali Shahbazi, Vivek Priy Dave, Tien Anh Ngo, Vinayaka Aaydha Chidambara, Linh Quyen Than, Dang Duong Bang, Anders Wolff
Microfluidic devices for sample preparation and rapid detection of foodborne pathogens
published pages: 1003-1024, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.03.002
Biotechnology Advances 36/4 2020-02-24
2018 Trieu Nguyen, Sune Zoëga Andreasen, Anders Wolff, Dang Duong Bang
From Lab on a Chip to Point of Care Devices: The Role of Open Source Microcontrollers
published pages: 403, ISSN: 2072-666X, DOI: 10.3390/mi9080403
Micromachines 9/8 2020-02-24
2018 Matthias Pilecky, Anita Schildberger, Dorothea Orth-Höller, Viktoria Weber
Pathogen enrichment from human whole blood for the diagnosis of bloodstream infection: Prospects and limitations
published pages: , ISSN: 0732-8893, DOI: 10.1016/j.diagmicrobio.2018.11.015
Diagnostic Microbiology and Infectious Disease 2020-02-24
2017 Jon Ashley, Mohammad-Ali Shahbazi, Krishna Kant, Vinayaka Aaydha Chidambara, Anders Wolff, Dang Duong Bang, Yi Sun
Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives
published pages: 606-615, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.01.018
Biosensors and Bioelectronics 91 2020-02-24
2019 K. Kant, T.A. Ngo, M. Matteucci, A. Wolff
Fabrication of 3D microstructure array on chip for rapid pathogen detection
published pages: 774-782, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.11.008
Sensors and Actuators B: Chemical 281 2020-02-24

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The information about "SMARTDIAGNOS" are provided by the European Opendata Portal: CORDIS opendata.

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