SMARTDIAGNOS SIGNED
Next generation sepsis diagnosis
Total Cost €
0EC-Contrib. €
0Partnership
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0SMARTDIAGNOS project word cloud
Explore the words cloud of the SMARTDIAGNOS project. It provides you a very rough idea of what is the project "SMARTDIAGNOS" about.
Project "SMARTDIAGNOS" data sheet
The following table provides information about the project.
| Coordinator |
DANMARKS TEKNISKE UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Project website | http://www.smartdiagnos.eu |
| Total cost | 4˙797˙602 € |
| EC max contribution | 4˙027˙909 € (84%) |
| Programme |
1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)) |
| Code Call | H2020-ICT-2015 |
| Funding Scheme | IA |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-02-01 to 2020-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | DANMARKS TEKNISKE UNIVERSITET | DK (KGS LYNGBY) | coordinator | 1˙393˙615.00 |
| 2 | CUBE DX GMBH | AT (ST VALENTIN) | participant | 721˙122.00 |
| 3 | SCANDINAVIAN MICRO BIODEVICES APS | DK (FARUM) | participant | 699˙953.00 |
| 4 | UNIVERSITAT FUR WEITERBILDUNG KREMS | AT (KREMS) | participant | 273˙550.00 |
| 5 | TATAA BIOCENTER AB | SE (GOTEBORG) | participant | 248˙624.00 |
| 6 | HOGSKOLAN I SKOVDE | SE (SKOVDE) | participant | 183˙500.00 |
| 7 | UNIVERZITA KARLOVA | CZ (PRAHA 1) | participant | 130˙000.00 |
| 8 | DIN DEUTSCHES INSTITUT FUER NORMUNG E.V. | DE (BERLIN) | participant | 128˙337.00 |
| 9 | UNILABS AB | SE (GOTEBORG) | participant | 126˙250.00 |
| 10 | COPENHAGEN BUSINESS SCHOOL | DK (FREDERIKSBERG) | participant | 122˙955.00 |
Map
Project objective
Sepsis is a potentially fatal condition that arises when the body’s response to an infection damages its own tissues and organs. It is mainly caused by bacteria and fungi, which spread through the blood circulation. It is one of the biggest public health issue in the EU and worldwide due to its high incidence, mortality, human and economic cost. Early diagnosis is crucial to the management of sepsis, as every hour of delay of appropriate antibiotic therapy increases mortality by 5-10%. Unfortunately, sepsis diagnosis remains one of the greatest clinical challenges in critical care. Current diagnostic methods, including blood culture and different nucleic acid based multiplex technologies, are impaired by the significant time-delay of 1-2 days and/or low sensitivity of 30-50%. Hence there is an urgent need to develop new diagnostic tools that can provide more accurate and earlier sepsis diagnosis, so that patients with sepsis can be administered with rapid and correct initial antimicrobial treatment. The SMARTDIAGNOS project will advance sepsis diagnosis by simplifying clinical sample analysis methods and integrating the currently required numerous steps into a single streamlined device. This will be achieved by combining a number of innovative technologies: 1) 3-dimentional sample concentration to process large amount of raw sample; 2) direct PCR in the 3D microstructure to circumvent DNA extraction step; 3) solid-phase PCR to achieve unlimited multiplexing capability; 4) supercritical angle fluorescence (SAF) microlens array for enhanced fluorescence detection and precise quantification of sepsis-related pathogens. The SMARTDIAGNOS system will go beyond the state of the art for shorter time (1-3 h), higher sensitivity (95%), higher selectivity (99%), multiplexing capability, antimicrobial resistance profiling, and automation. Fast and correct sepsis diagnosis will improve patient outcome, shorten intensive care stay and thus reduce health costs.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Tran Quang Hung, Wai Hoe Chin, Yi Sun, Anders Wolff, Dang Duong Bang A novel lab-on-chip platform with integrated solid phase PCR and Supercritical Angle Fluorescence (SAF) microlens array for highly sensitive and multiplexed pathogen detection published pages: 217-223, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.11.028 |
Biosensors and Bioelectronics 90 | 2020-02-24 |
| 2018 |
Vivek Priy Dave, Tien Anh Ngo, Anna-Karin Pernestig, Diana Tilevik, Krishna Kant, Trieu Nguyen, Anders Wolff, Dang Duong Bang MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics published pages: , ISSN: 0023-6837, DOI: 10.1038/s41374-018-0143-3 |
Laboratory Investigation | 2020-02-24 |
| 2019 |
Aaydha C. Vinayaka, Tien A. Ngo, Krishna Kant, Pia Engelsmann, Vivek P. Dave, Mohammad-Ali Shahbazi, Anders Wolff, Dang D. Bang Rapid detection of Salmonella enterica in food samples by a novel approach with combination of sample concentration and direct PCR published pages: 224-230, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.09.078 |
Biosensors and Bioelectronics 129 | 2020-02-24 |
| 2018 |
Krishna Kant, Mohammad-Ali Shahbazi, Vivek Priy Dave, Tien Anh Ngo, Vinayaka Aaydha Chidambara, Linh Quyen Than, Dang Duong Bang, Anders Wolff Microfluidic devices for sample preparation and rapid detection of foodborne pathogens published pages: 1003-1024, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.03.002 |
Biotechnology Advances 36/4 | 2020-02-24 |
| 2018 |
Trieu Nguyen, Sune Zoëga Andreasen, Anders Wolff, Dang Duong Bang From Lab on a Chip to Point of Care Devices: The Role of Open Source Microcontrollers published pages: 403, ISSN: 2072-666X, DOI: 10.3390/mi9080403 |
Micromachines 9/8 | 2020-02-24 |
| 2018 |
Matthias Pilecky, Anita Schildberger, Dorothea Orth-Höller, Viktoria Weber Pathogen enrichment from human whole blood for the diagnosis of bloodstream infection: Prospects and limitations published pages: , ISSN: 0732-8893, DOI: 10.1016/j.diagmicrobio.2018.11.015 |
Diagnostic Microbiology and Infectious Disease | 2020-02-24 |
| 2017 |
Jon Ashley, Mohammad-Ali Shahbazi, Krishna Kant, Vinayaka Aaydha Chidambara, Anders Wolff, Dang Duong Bang, Yi Sun Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives published pages: 606-615, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.01.018 |
Biosensors and Bioelectronics 91 | 2020-02-24 |
| 2019 |
K. Kant, T.A. Ngo, M. Matteucci, A. Wolff Fabrication of 3D microstructure array on chip for rapid pathogen detection published pages: 774-782, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.11.008 |
Sensors and Actuators B: Chemical 281 | 2020-02-24 |
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