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SyBil-AA SIGNED

Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 SyBil-AA project word cloud

Explore the words cloud of the SyBil-AA project. It provides you a very rough idea of what is the project "SyBil-AA" about.

unmet    verified    strategy    translational    positively    alcohol    population    discovery    directed    proneness    ranks    resonance    expertise    interdisciplinary    possibility    disabilities    hubs    successful    therapies    guide    showing    aberrant    assembled    mathematical    strategies    sites    magnetic    addiction    preventable    neurochemical    imaging    tested    animal    treatment    resilience    proof    models    dynamics    rational    therapeutic    data    experimental    disorder    rigorously    framework    largely    laboratory    brain    world    remodeling    global    causes    prescribed    patients    gap    death    utilize    societies    countries    serious    biology    functional    predictive    health    fmri    networks    limited    modeling    uses    prone    clinical    human    predictions    skills    experiments    network    complementary    predict    theoretical    normalized    primary    options    fill    eight    class    relapse    missing    animals    humans    transferred    interventions   

Project "SyBil-AA" data sheet

The following table provides information about the project.

Coordinator
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT 

Organization address
address: Square J 5
city: MANNHEIM
postcode: 68159
website: www.zi-mannheim.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://sybil-aa.eu/
 Total cost 5˙759˙923 €
 EC max contribution 5˙759˙923 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT DE (MANNHEIM) coordinator 1˙861˙352.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 550˙000.00
3    THE UNIVERSITY OF SUSSEX UK (BRIGHTON) participant 449˙943.00
4    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 448˙258.00
5    LINKOPINGS UNIVERSITET SE (LINKOPING) participant 416˙625.00
6    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 408˙687.00
7    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 389˙791.00
8    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) participant 259˙252.00
9    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 250˙000.00
10    INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE RO (CLUJ-NAPOCA) participant 227˙826.00
11    ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE RO (CLUJ NAPOCA) participant 186˙298.00
12    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 161˙140.00
13    BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD IL (JERUSALEM) participant 150˙747.00
14    METANOMICS HEALTH GMBH DE (Berlin) participant 0.00
15    OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG DE (MAGDEBURG) participant 0.00

Map

 Project objective

Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the ‘relapse-prone’ state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote ‘relapse-proneness’ and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.

 Deliverables

List of deliverables.
Targeted Publication in Addiction-related journals Documents, reports 2020-01-15 09:46:11
Kick-off Meeting report Documents, reports 2020-01-15 09:46:10
External SyBil-AA website and promotion video Websites, patent fillings, videos etc. 2020-01-15 09:46:10

Take a look to the deliverables list in detail:  detailed list of SyBil-AA deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Patrick Bach, Anne Koopmann, Jan Malte Bumb, Sina Zimmermann, Sina Bühler, Iris Reinhard, Stephanie H. Witt, Marcella Rietschel, Sabine Vollstädt-Klein, Falk Kiefer
Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study
published pages: , ISSN: 0940-1334, DOI: 10.1007/s00406-020-01115-0
European Archives of Psychiatry and Clinical Neuroscience 2020-03-05
2019 Stefano Tambalo, Giulia Scuppa, Angelo Bifone
Segmented Echo Planar Imaging Improves Detection of Subcortical Functional Connectivity Networks in the Rat Brain
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37863-2
Scientific Reports 9/1 2020-02-19
2020 Franziska Weiss, Vera Zamoscik, Stephanie N.L. Schmidt, Patrick Halli, Peter Kirsch, Martin Fungisai Gerchen
Just a very expensive breathing training? Risk of respiratory artefacts in functional connectivity-based real-time fMRI neurofeedback
published pages: 116580, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2020.116580
NeuroImage 210 2020-02-13
2019 Fathizadeh, F.; Mitricheva, E.; Kimura, R.; Logothetis, N.; Noori, H.
Signal detection in extracellular neural ensemble recordings using higher criticism
published pages: , ISSN: , DOI:
5 2020-01-30
2018 Martin Fungisai Gerchen, Alena Rentsch, Martina Kirsch, Falk Kiefer, Peter Kirsch
Shifts in the functional topography of frontal cortex‐striatum connectivity in alcohol use disorder
published pages: 1245-1253, ISSN: 1355-6215, DOI: 10.1111/adb.12692
Addiction Biology 24/6 2020-01-30
2019 Lisamon Egenrieder, Ekaterina Mitricheva, Rainer Spanagel, Hamid R. Noori
No basal or drug‐induced sex differences in striatal dopaminergic levels: a cluster and meta‐analysis of rat microdialysis studies
published pages: , ISSN: 0022-3042, DOI: 10.1111/jnc.14911
Journal of Neurochemistry 2020-01-30
2018 Răzvan Gămănuţ, Henry Kennedy, Zoltán Toroczkai, Mária Ercsey-Ravasz, David C. Van Essen, Kenneth Knoblauch, Andreas Burkhalter
The Mouse Cortical Connectome, Characterized by an Ultra-Dense Cortical Graph, Maintains Specificity by Distinct Connectivity Profiles
published pages: 698-715.e10, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.12.037
Neuron 97/3 2020-01-30
2019 Irene Perini, Robin Kämpe, Theodor Arlestig, Hanna Karlsson, Andreas Löfberg, Michal Pietrzak, Abraham Zangen, Markus Heilig
Repetitive transcranial magnetic stimulation targeting the insular cortex for reduction of heavy drinking in treatment-seeking alcohol-dependent subjects: a randomized controlled trial
published pages: , ISSN: 0893-133X, DOI: 10.1038/s41386-019-0565-7
Neuropsychopharmacology 2020-01-30
2019 Dongmei Shi, Anna Levina, Hamid R. Noori
Refined parcellation of the nervous system by algorithmic detection of hidden features within communities
published pages: , ISSN: 2470-0045, DOI: 10.1103/physreve.100.012301
Physical Review E 100/1 2020-01-30
2019 Ekaterina Mitricheva, Rui Kimura, Nikos K. Logothetis, Hamid R. Noori
Neural substrates of sexual arousal are not sex dependent
published pages: 15671-15676, ISSN: 0027-8424, DOI: 10.1073/pnas.1904975116
Proceedings of the National Academy of Sciences 116/31 2020-01-30
2020 Ciuparu A., Nagy-Dăbâcan A., Muresan R.C.
Soft++, a multi-parametric non-saturating non-linearity that improves convergence in deep neural architectures
published pages: , ISSN: 0925-2312, DOI:
Neurocomputing 2020-01-30
2019 Christina Dinter, Derik Hermann, Judith Heckmann, Holger Hill, Iris Reinhard, Sabine Vollstädt‐Klein, Peter Kirsch, Falk Kiefer
Reconsolidation impairment of reward memory by stimulating stress response
published pages: , ISSN: 1355-6215, DOI: 10.1111/adb.12712
Addiction Biology 25/1 2020-01-30
2019 Markus Heilig, Eric Augier, Simone Pfarr, Wolfgang H. Sommer
Developing neuroscience-based treatments for alcohol addiction: A matter of choice?
published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-019-0591-6
Translational Psychiatry 9/1 2020-01-15
2019 Silvia De Santis, Wolfgang H. Sommer, Santiago Canals
Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging
published pages: 4187-4189, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.9b00481
ACS Chemical Neuroscience 10/10 2020-01-15
2019 Giulia Scuppa, Stefano Tambalo, Simone Pfarr, Wolfgang H. Sommer, Angelo Bifone
Aberrant insular cortex connectivity in abstinent alcohol-dependent rats is reversed by dopamine D3 receptor blockade
published pages: , ISSN: 1355-6215, DOI: 10.1111/adb.12744
Addiction Biology 2020-01-15
2018 Gino Del Ferraro, Andrea Moreno, Byungjoon Min, Flaviano Morone, Úrsula Pérez-Ramírez, Laura Pérez-Cervera, Lucas C. Parra, Andrei Holodny, Santiago Canals, Hernán A. Makse
Finding influential nodes for integration in brain networks using optimal percolation theory
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04718-3
Nature Communications 9/1 2020-01-15
2018 Aleksandra M. Herman, Hugo D. Critchley, Theodora Duka
Binge drinking is associated with attenuated frontal and parietal activation during successful response inhibition in fearful context
published pages: , ISSN: 0953-816X, DOI: 10.1111/ejn.14108
European Journal of Neuroscience 2020-01-15
2018 Carlo Nicolini, Vladimir Vlasov, Angelo Bifone
Thermodynamics of network model fitting with spectral entropies
published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.98.022322
Physical Review E 98/2 2020-01-15
2017 Zsolt I. Lázár, István Papp, Levente Varga, Ferenc Járai-Szabó, Dávid Deritei, Mária Ercsey-Ravasz
Stochastic graph Voronoi tessellation reveals community structure
published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.95.022306
Physical Review E 95/2 2020-01-15
2017 Cécile Bordier, Carlo Nicolini, Angelo Bifone
Graph Analysis and Modularity of Brain Functional Connectivity Networks: Searching for the Optimal Threshold
published pages: 441, ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00441
Frontiers in Neuroscience 11 2020-01-15
2018 Anita C. Hansson, Gerhard Gründer, Natalie Hirth, Hamid R. Noori, Rainer Spanagel, Wolfgang H. Sommer
Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies
published pages: , ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.010
Neuroscience & Biobehavioral Reviews 2020-01-15
2019 Silvia De Santis, Patrick Bach, Laura Pérez-Cervera, Alejandro Cosa-Linan, Georg Weil, Sabine Vollstädt-Klein, Derik Hermann, Falk Kiefer, Peter Kirsch, Roberto Ciccocioppo, Wolfgang H. Sommer, Santiago Canals
Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence
published pages: , ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2019.0318
JAMA Psychiatry 2020-01-15
2017 Silvia De Santis, David Moratal, Santiago Canals
Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis
published pages: , ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.11.055
Neuroscience 2020-01-15
2019 Patrick Bach, Georg Weil, Enrico Pompili, Sabine Hoffmann, Derik Hermann, Sabine Vollstädt-Klein, Karl Mann, Ursula Perez-Ramirez, David Moratal, Santiago Canals, Serdar M. Dursun, Andrew J. Greenshaw, Peter Kirsch, Falk Kiefer, Wolfgang H. Sommer
Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone
published pages: , ISSN: 1355-6215, DOI: 10.1111/adb.12717
Addiction Biology 2020-01-15
2018 Aref Pariz, Zahra G. Esfahani, Shervin S. Parsi, Alireza Valizadeh, Santiago Canals, Claudio R. Mirasso
High frequency neurons determine effective connectivity in neuronal networks
published pages: 349-359, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.11.014
NeuroImage 166 2020-01-15
2018 Hamid R. Noori, Lewis H. Mervin, Vahid Bokharaie, Özlem Durmus, Lisamon Egenrieder, Stefan Fritze, Britta Gruhlke, Giulia Reinhardt, Hans-Hendrik Schabel, Sabine Staudenmaier, Nikos K. Logothetis, Andreas Bender, Rainer Spanagel
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07239-1
Nature Communications 9/1 2020-01-15

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