Explore the words cloud of the SyBil-AA project. It provides you a very rough idea of what is the project "SyBil-AA" about.
The following table provides information about the project.
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
|Coordinator Country||Germany [DE]|
|Total cost||5˙759˙923 €|
|EC max contribution||5˙759˙923 € (100%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2016-01-01 to 2019-12-31|
Take a look of project's partnership.
|1||ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT||DE (MANNHEIM)||coordinator||1˙861˙352.00|
|2||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (München)||participant||550˙000.00|
|3||THE UNIVERSITY OF SUSSEX||UK (BRIGHTON)||participant||449˙943.00|
|4||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||participant||448˙258.00|
|5||LINKOPINGS UNIVERSITET||SE (Linköping)||participant||416˙625.00|
|6||HELSINGIN YLIOPISTO||FI (HELSINGIN YLIOPISTO)||participant||408˙687.00|
|7||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||participant||389˙791.00|
|8||BEN-GURION UNIVERSITY OF THE NEGEV||IL (BEER SHEVA)||participant||259˙252.00|
|9||UNIVERSITEIT LEIDEN||NL (LEIDEN)||participant||250˙000.00|
|10||INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE||RO (CLUJ-NAPOCA)||participant||227˙826.00|
|11||ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE||RO (CLUJ NAPOCA)||participant||186˙298.00|
|12||THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||participant||161˙140.00|
|13||BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD||IL (JERUSALEM)||participant||150˙747.00|
|14||METANOMICS HEALTH GMBH||DE (Berlin)||participant||0.00|
|15||OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG||DE (MAGDEBURG)||participant||0.00|
Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the ‘relapse-prone’ state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote ‘relapse-proneness’ and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.
Work performed, outcomes and results: advancements report(s)
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The information about "SYBIL-AA" are provided by the European Opendata Portal: CORDIS opendata.
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