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SyBil-AA SIGNED

Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "SyBil-AA" data sheet

The following table provides information about the project.

Coordinator
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT 

Organization address
address: Square J 5
city: MANNHEIM
postcode: 68159
website: www.zi-mannheim.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 5˙759˙923 €
 EC max contribution 5˙759˙923 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme /RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT DE (MANNHEIM) coordinator 1˙861˙352.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (München) participant 550˙000.00
3    THE UNIVERSITY OF SUSSEX UK (BRIGHTON) participant 449˙943.00
4    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 448˙258.00
5    LINKOPINGS UNIVERSITET SE (Linköping) participant 416˙625.00
6    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 408˙687.00
7    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 389˙791.00
8    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) participant 259˙252.00
9    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 250˙000.00
10    INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE RO (CLUJ-NAPOCA) participant 227˙826.00
11    ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE RO (CLUJ NAPOCA) participant 186˙298.00
12    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 161˙140.00
13    BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD IL (JERUSALEM) participant 150˙747.00
14    METANOMICS HEALTH GMBH DE (Berlin) participant 0.00
15    OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG DE (MAGDEBURG) participant 0.00

Mappa

 Project objective

Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the ‘relapse-prone’ state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote ‘relapse-proneness’ and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "SYBIL-AA" are provided by the European Opendata Portal: CORDIS opendata.

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