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Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine

Total Cost €


EC-Contrib. €






 ATLAS project word cloud

Explore the words cloud of the ATLAS project. It provides you a very rough idea of what is the project "ATLAS" about.

regeneration    generalised    models    compartmentalise    organization    engineering    cell    edge    ground    multilayers    local    truly    self    arrangement    components    faster    smart    basic    incorporated    therapies    mechanical    microtissue    variety    attachment    toolboxes    post    organizational    dialogue    innovative    tissue    chemistry    quasi    origin    adjust    3d    matrix    micro    immune    combining    types    drug    paracrine    generations    versatile    niche    supramolecular    closed    engineer    assembly    biopolymers    new    biomimetic    biochemical    nanostratified    deconstruction    function    te    physical    stem    cascade    minimum    bio    bone    direct    front    integrate    building    time    hematopoietic    degradation    physiology    2d    regulated    vitro    native    macromolecules    globe    backbone    cues    instructive    equipped    units    extra    ingredients    films    skeletal    proposes    cells    quality    multiple    structural    blocks    cellular    signals    hybrid    structures    patterning    interactions    rationalize    exchanging    atlas    permit    specific    marine    capsules    biomaterials    permitting    sophisticated    architect    discovery    chemical    tandem    disease    breaking   

Project "ATLAS" data sheet

The following table provides information about the project.


Organization address
city: AVEIRO
postcode: 3810-193

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website
 Total cost 2˙498˙987 €
 EC max contribution 2˙498˙987 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DE AVEIRO PT (AVEIRO) coordinator 2˙438˙987.00
2    UNIVERSIDADE DO MINHO PT (BRAGA) participant 60˙000.00


 Project objective

New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine and direct signals, structural and chemical arrangement of the extra-cellular matrix, mechanical signals…) should be then incorporated into the design of truly biomimetic biomaterials. ATLAS proposes rather unique toolboxes combining smart biomaterials and cells for the ground-breaking advances of engineering fully time-self-regulated complex 2D and 3D devices, able to adjust the cascade of processes leading to faster high-quality new tissue formation with minimum pre-processing of cells. Versatile biomaterials based on marine-origin macromolecules will be used, namely in the supramolecular assembly of instructive multilayers as nanostratified building-blocks for engineer such structures. The backbone of these biopolymers will be equipped with a variety of (bio)chemical elements permitting: post-processing chemistry and micro-patterning, specific/non-specific cell attachment, and cell-controlled degradation. Aiming at being applied in bone TE, ATLAS will integrate cells from different units of tissue physiology, namely bone and hematopoietic basic elements and consider the interactions between the immune and skeletal systems. These ingredients will permit to architect innovative films with high-level dialogue control with cells, but in particular sophisticated quasi-closed 3D capsules able to compartmentalise such components in a “globe-like” organization, providing local and long-range order for in vitro microtissue development and function. Such hybrid devices could be used in more generalised front-edge applications, including as disease models for drug discovery or test new therapies in vitro.


year authors and title journal last update
List of publications.
2018 Isabel M. Bjørge, Ana M. S. Costa, A. Sofia Silva, João P. O. Vidal, J. Miguel Nóbrega, João F. Mano
Tuneable spheroidal hydrogel particles for cell and drug encapsulation
published pages: 5622-5627, ISSN: 1744-683X, DOI: 10.1039/c8sm00921j
Soft Matter 14/27 2019-06-06
2018 Álvaro J. Leite, Nuno M. Oliveira, Wenlong Song, João F. Mano
Bioactive Hydrogel Marbles
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33192-6
Scientific Reports 8/1 2019-06-06
2019 Nuno M. Oliveira, Sara Vilabril, Mariana B. Oliveira, Rui L. Reis, João F. Mano
Recent advances on open fluidic systems for biomedical applications: A review
published pages: 851-863, ISSN: 0928-4931, DOI: 10.1016/j.msec.2018.12.040
Materials Science and Engineering: C 97 2019-06-06
2018 Maria P. Sousa, Ana I. Neto, Tiago R. Correia, Sónia P. Miguel, Michiya Matsusaki, Ilídio J. Correia, João F. Mano
Bioinspired multilayer membranes as potential adhesive patches for skin wound healing
published pages: 1962-1975, ISSN: 2047-4830, DOI: 10.1039/c8bm00319j
Biomaterials Science 6/7 2019-06-06
2018 Sara Catarina Nunes da Silva Santos, Ólafur Eysteinn Sigurjonsson, Catarina de Almeida Custódio, João Filipe Colardelle da Luz Mano
Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies
published pages: 454-462, ISSN: 1937-3368, DOI: 10.1089/ten.TEB.2018.0008
Tissue Engineering Part B: Reviews 24/6 2019-06-06
2018 Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Bioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation
published pages: 1800890, ISSN: 2192-2640, DOI: 10.1002/adhm.201800890
Advanced Healthcare Materials 7/19 2019-06-06
2018 L.P. Ferreira, V.M. Gaspar, J.F. Mano
Bioinstructive microparticles for self-assembly of mesenchymal stem Cell-3D tumor spheroids
published pages: 155-173, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.09.007
Biomaterials 185 2019-06-06
2018 C.R. Martins, C.A. Custódio, J.F. Mano
Multifunctional laminarin microparticles for cell adhesion and expansion
published pages: 91-98, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2018.08.029
Carbohydrate Polymers 202 2019-06-06
2018 L.P. Ferreira, V.M. Gaspar, J.F. Mano
Design of spherically structured 3D in vitro tumor models -Advances and prospects
published pages: 11-34, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.05.034
Acta Biomaterialia 75 2019-06-07
2017 Ana M. S. Costa, João F. Mano
Solvent-Free Strategy Yields Size and Shape-Uniform Capsules
published pages: 1057-1060, ISSN: 0002-7863, DOI: 10.1021/jacs.6b11925
Journal of the American Chemical Society 139/3 2019-06-06
2018 Diana Lopes, Cláudia Martins-Cruz, Mariana B. Oliveira, João F. Mano
Bone physiology as inspiration for tissue regenerative therapies
published pages: 240-275, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.09.028
Biomaterials 185 2019-06-06
2018 Mariana B. Oliveira, Henrique X. S. Bastos, João F. Mano
Sequentially Moldable and Bondable Four-Dimensional Hydrogels Compatible with Cell Encapsulation
published pages: 2742-2749, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00337
Biomacromolecules 19/7 2019-06-06
2017 Clara R. Correia, Joana Gaifem, Mariana B. Oliveira, Ricardo Silvestre, João F. Mano
The influence of surface modified poly( l -lactic acid) films on the differentiation of human monocytes into macrophages
published pages: 551-560, ISSN: 2047-4830, DOI: 10.1039/C6BM00920D
Biomaterials Science 5/3 2019-06-06
2017 Maria Sousa, João Mano
Cell-Adhesive Bioinspired and Catechol-Based Multilayer Freestanding Membranes for Bone Tissue Engineering
published pages: 19, ISSN: 2313-7673, DOI: 10.3390/biomimetics2040019
Biomimetics 2/4 2019-06-06
2016 Catarina A. Custódio, João F. Mano
Cell Surface Engineering to Control Cellular Interactions
published pages: 376-384, ISSN: 2199-692X, DOI: 10.1002/cnma.201600047
ChemNanoMat 2/5 2019-06-06
2018 Pedro Lavrador, Vítor M. Gaspar, João F. Mano
Stimuli-responsive nanocarriers for delivery of bone therapeutics – Barriers and progresses
published pages: 51-67, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.01.021
Journal of Controlled Release 273 2019-06-06
2017 João Borges, Maria P. Sousa, Goksu Cinar, Sofia G. Caridade, Mustafa O. Guler, João F. Mano
Nanoengineering Hybrid Supramolecular Multilayered Biomaterials Using Polysaccharides and Self-Assembling Peptide Amphiphiles
published pages: 1605122, ISSN: 1616-301X, DOI: 10.1002/adfm.201605122
Advanced Functional Materials 27/17 2019-06-06
2017 Luís P. Ferreira, Vítor M. Gaspar, Rui Henrique, Carmen Jerónimo, João F. Mano
Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models
published pages: 1700079, ISSN: 1860-6768, DOI: 10.1002/biot.201700079
Biotechnology Journal 12/12 2019-06-06
2016 Matias Cardoso, Rui Costa, João Mano
Marine Origin Polysaccharides in Drug Delivery Systems
published pages: 34, ISSN: 1660-3397, DOI: 10.3390/md14020034
Marine Drugs 14/2 2019-04-03

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