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UNRAVEL

Understanding the Role of Antisense lncRNA in Vernalization, Memory and Life History

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UNRAVEL project word cloud

Explore the words cloud of the UNRAVEL project. It provides you a very rough idea of what is the project "UNRAVEL" about.

commercial    organization    sites    contributes    function    functional    dynamics    plays    phenotypes    autonomous    coding    catalysing    differences    time    cell    myself    structures    structure    mobility    creative    contact    host    protein    plants    relationships    tight    rna    site    vivo    significantly    disrupt    antisense    epigenetic    lncrnas    occurs    slower    2020    mediated    lines    ing    unclear    goals    alleles    knockout    mechanism    vitro    plant    chromatin    underlying    prolonged    transcription    arabidopsis    engagement    model    cues    academic    competences    acting    integration    cold    transferable    natural    flc    conserved    secondary    binding    signals    switch    flowering    thaliana    training    winter    public    silencing    international    career    regulates    regulation    quantitatively    broadly    networks    mutagenesis    eukaryotes    altered    developmental    environmental    modification    horizon    directed    relationship    expression    skills    coolair    transcribed    diversifying   

Project "UNRAVEL" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

Map

 Project objective

In the model plant Arabidopsis thaliana, the integration of complex developmental and environmental cues to determine flowering time occurs via tight regulation of FLC. During winter, prolonged cold quantitatively down-regulates FLC expression at the whole-plant level, acting via a cell-autonomous epigenetic switch. A long non-coding RNA, COOLAIR, is transcribed antisense to FLC and plays a key role in this switch. COOLAIR knockout lines show slower silencing of FLC in the cold and altered chromatin modification dynamics. However, the mechanism by which this is achieved remains unclear. My objective is to determine the relationships between COOLAIR transcription, secondary structure and function in the epigenetic silencing of FLC. I will determine in vitro and in vivo secondary structures for COOLAIR in two natural A. thaliana alleles with functional differences in FLC silencing and flowering time. Using both natural alleles and site-directed mutagenesis to disrupt COOLAIR secondary structure, I will assess resulting FLC silencing and flowering phenotypes to investigate the structure-function relationship. Finally, I will develop a method for identifying specific protein-binding partners and sites in COOLAIR. This research will significantly enhance our knowledge of the mechanism underlying cold-mediated silencing in FLC specifically, and of the integration of long-term environmental signals in plants in general. More broadly, it contributes to our emerging understanding of the role of lncRNAs in an epigenetic silencing mechanism that is conserved across the higher eukaryotes. This proposal is directly relevant to the Horizon 2020 Work Programme goals: developing my creative potential and diversifying competences through international mobility and advanced training in technical and transferable skills; enhancing contact networks for both myself and my host organization through academic, commercial and public engagement; and catalysing significant career development.

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