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UNRAVEL

Understanding the Role of Antisense lncRNA in Vernalization, Memory and Life History

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UNRAVEL project word cloud

Explore the words cloud of the UNRAVEL project. It provides you a very rough idea of what is the project "UNRAVEL" about.

eukaryotes    autonomous    mechanism    transcription    phenotypes    binding    diversifying    model    commercial    coding    knockout    thaliana    expression    environmental    cold    significantly    directed    developmental    time    lines    relationships    alleles    tight    switch    prolonged    conserved    vivo    sites    mediated    structure    transferable    quantitatively    mutagenesis    differences    catalysing    lncrnas    unclear    occurs    site    slower    ing    myself    plant    career    transcribed    acting    cell    networks    flowering    plays    regulation    disrupt    epigenetic    dynamics    goals    international    2020    structures    public    modification    regulates    rna    plants    contributes    horizon    coolair    arabidopsis    broadly    organization    vitro    training    protein    academic    integration    secondary    cues    antisense    contact    function    signals    host    underlying    relationship    chromatin    winter    silencing    engagement    creative    natural    mobility    skills    competences    flc    altered    functional   

Project "UNRAVEL" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

Map

 Project objective

In the model plant Arabidopsis thaliana, the integration of complex developmental and environmental cues to determine flowering time occurs via tight regulation of FLC. During winter, prolonged cold quantitatively down-regulates FLC expression at the whole-plant level, acting via a cell-autonomous epigenetic switch. A long non-coding RNA, COOLAIR, is transcribed antisense to FLC and plays a key role in this switch. COOLAIR knockout lines show slower silencing of FLC in the cold and altered chromatin modification dynamics. However, the mechanism by which this is achieved remains unclear. My objective is to determine the relationships between COOLAIR transcription, secondary structure and function in the epigenetic silencing of FLC. I will determine in vitro and in vivo secondary structures for COOLAIR in two natural A. thaliana alleles with functional differences in FLC silencing and flowering time. Using both natural alleles and site-directed mutagenesis to disrupt COOLAIR secondary structure, I will assess resulting FLC silencing and flowering phenotypes to investigate the structure-function relationship. Finally, I will develop a method for identifying specific protein-binding partners and sites in COOLAIR. This research will significantly enhance our knowledge of the mechanism underlying cold-mediated silencing in FLC specifically, and of the integration of long-term environmental signals in plants in general. More broadly, it contributes to our emerging understanding of the role of lncRNAs in an epigenetic silencing mechanism that is conserved across the higher eukaryotes. This proposal is directly relevant to the Horizon 2020 Work Programme goals: developing my creative potential and diversifying competences through international mobility and advanced training in technical and transferable skills; enhancing contact networks for both myself and my host organization through academic, commercial and public engagement; and catalysing significant career development.

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