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Understanding the Role of Antisense lncRNA in Vernalization, Memory and Life History

Total Cost €


EC-Contrib. €






 UNRAVEL project word cloud

Explore the words cloud of the UNRAVEL project. It provides you a very rough idea of what is the project "UNRAVEL" about.

secondary    cold    vivo    chromatin    plays    goals    academic    dynamics    creative    unclear    mechanism    quantitatively    eukaryotes    silencing    winter    occurs    prolonged    skills    arabidopsis    epigenetic    lines    relationships    mobility    organization    diversifying    coding    flowering    catalysing    host    slower    antisense    knockout    time    function    competences    directed    mutagenesis    commercial    structure    public    horizon    expression    alleles    rna    vitro    underlying    broadly    coolair    natural    international    cell    phenotypes    model    flc    environmental    contributes    site    switch    regulation    plant    signals    significantly    developmental    relationship    structures    sites    modification    conserved    acting    lncrnas    contact    myself    binding    thaliana    protein    tight    differences    disrupt    functional    mediated    transferable    transcribed    engagement    autonomous    career    training    plants    networks    ing    regulates    2020    cues    transcription    integration    altered   

Project "UNRAVEL" data sheet

The following table provides information about the project.


Organization address
postcode: NR4 7UH

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00


 Project objective

In the model plant Arabidopsis thaliana, the integration of complex developmental and environmental cues to determine flowering time occurs via tight regulation of FLC. During winter, prolonged cold quantitatively down-regulates FLC expression at the whole-plant level, acting via a cell-autonomous epigenetic switch. A long non-coding RNA, COOLAIR, is transcribed antisense to FLC and plays a key role in this switch. COOLAIR knockout lines show slower silencing of FLC in the cold and altered chromatin modification dynamics. However, the mechanism by which this is achieved remains unclear. My objective is to determine the relationships between COOLAIR transcription, secondary structure and function in the epigenetic silencing of FLC. I will determine in vitro and in vivo secondary structures for COOLAIR in two natural A. thaliana alleles with functional differences in FLC silencing and flowering time. Using both natural alleles and site-directed mutagenesis to disrupt COOLAIR secondary structure, I will assess resulting FLC silencing and flowering phenotypes to investigate the structure-function relationship. Finally, I will develop a method for identifying specific protein-binding partners and sites in COOLAIR. This research will significantly enhance our knowledge of the mechanism underlying cold-mediated silencing in FLC specifically, and of the integration of long-term environmental signals in plants in general. More broadly, it contributes to our emerging understanding of the role of lncRNAs in an epigenetic silencing mechanism that is conserved across the higher eukaryotes. This proposal is directly relevant to the Horizon 2020 Work Programme goals: developing my creative potential and diversifying competences through international mobility and advanced training in technical and transferable skills; enhancing contact networks for both myself and my host organization through academic, commercial and public engagement; and catalysing significant career development.

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