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UNRAVEL

Understanding the Role of Antisense lncRNA in Vernalization, Memory and Life History

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UNRAVEL project word cloud

Explore the words cloud of the UNRAVEL project. It provides you a very rough idea of what is the project "UNRAVEL" about.

model    binding    functional    coding    protein    skills    unclear    flc    ing    cold    autonomous    developmental    mechanism    transcribed    significantly    differences    horizon    underlying    dynamics    chromatin    host    flowering    environmental    antisense    slower    organization    tight    altered    conserved    coolair    commercial    regulation    structure    international    directed    cell    mediated    acting    structures    academic    phenotypes    goals    competences    epigenetic    lncrnas    modification    lines    alleles    career    quantitatively    function    vitro    thaliana    disrupt    plant    expression    mutagenesis    time    engagement    catalysing    integration    cues    networks    myself    secondary    switch    sites    diversifying    vivo    prolonged    creative    contributes    relationships    2020    rna    site    arabidopsis    transferable    natural    occurs    contact    plays    transcription    eukaryotes    knockout    broadly    training    regulates    plants    public    mobility    silencing    signals    winter    relationship   

Project "UNRAVEL" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

Map

 Project objective

In the model plant Arabidopsis thaliana, the integration of complex developmental and environmental cues to determine flowering time occurs via tight regulation of FLC. During winter, prolonged cold quantitatively down-regulates FLC expression at the whole-plant level, acting via a cell-autonomous epigenetic switch. A long non-coding RNA, COOLAIR, is transcribed antisense to FLC and plays a key role in this switch. COOLAIR knockout lines show slower silencing of FLC in the cold and altered chromatin modification dynamics. However, the mechanism by which this is achieved remains unclear. My objective is to determine the relationships between COOLAIR transcription, secondary structure and function in the epigenetic silencing of FLC. I will determine in vitro and in vivo secondary structures for COOLAIR in two natural A. thaliana alleles with functional differences in FLC silencing and flowering time. Using both natural alleles and site-directed mutagenesis to disrupt COOLAIR secondary structure, I will assess resulting FLC silencing and flowering phenotypes to investigate the structure-function relationship. Finally, I will develop a method for identifying specific protein-binding partners and sites in COOLAIR. This research will significantly enhance our knowledge of the mechanism underlying cold-mediated silencing in FLC specifically, and of the integration of long-term environmental signals in plants in general. More broadly, it contributes to our emerging understanding of the role of lncRNAs in an epigenetic silencing mechanism that is conserved across the higher eukaryotes. This proposal is directly relevant to the Horizon 2020 Work Programme goals: developing my creative potential and diversifying competences through international mobility and advanced training in technical and transferable skills; enhancing contact networks for both myself and my host organization through academic, commercial and public engagement; and catalysing significant career development.

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