Opendata, web and dolomites

UNRAVEL

Understanding the Role of Antisense lncRNA in Vernalization, Memory and Life History

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 UNRAVEL project word cloud

Explore the words cloud of the UNRAVEL project. It provides you a very rough idea of what is the project "UNRAVEL" about.

relationships    sites    structure    function    relationship    broadly    coding    acting    environmental    chromatin    flc    ing    significantly    plays    epigenetic    horizon    goals    career    lncrnas    international    regulates    alleles    mobility    developmental    contributes    winter    dynamics    differences    arabidopsis    expression    model    training    engagement    public    autonomous    time    networks    host    mechanism    cold    structures    rna    mutagenesis    myself    cues    directed    diversifying    plant    protein    antisense    altered    mediated    integration    prolonged    switch    regulation    flowering    vivo    catalysing    natural    transferable    thaliana    eukaryotes    lines    phenotypes    contact    skills    signals    slower    site    underlying    tight    functional    conserved    creative    binding    unclear    disrupt    quantitatively    commercial    silencing    knockout    secondary    coolair    cell    plants    organization    vitro    modification    competences    2020    transcription    transcribed    academic    occurs   

Project "UNRAVEL" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

Map

 Project objective

In the model plant Arabidopsis thaliana, the integration of complex developmental and environmental cues to determine flowering time occurs via tight regulation of FLC. During winter, prolonged cold quantitatively down-regulates FLC expression at the whole-plant level, acting via a cell-autonomous epigenetic switch. A long non-coding RNA, COOLAIR, is transcribed antisense to FLC and plays a key role in this switch. COOLAIR knockout lines show slower silencing of FLC in the cold and altered chromatin modification dynamics. However, the mechanism by which this is achieved remains unclear. My objective is to determine the relationships between COOLAIR transcription, secondary structure and function in the epigenetic silencing of FLC. I will determine in vitro and in vivo secondary structures for COOLAIR in two natural A. thaliana alleles with functional differences in FLC silencing and flowering time. Using both natural alleles and site-directed mutagenesis to disrupt COOLAIR secondary structure, I will assess resulting FLC silencing and flowering phenotypes to investigate the structure-function relationship. Finally, I will develop a method for identifying specific protein-binding partners and sites in COOLAIR. This research will significantly enhance our knowledge of the mechanism underlying cold-mediated silencing in FLC specifically, and of the integration of long-term environmental signals in plants in general. More broadly, it contributes to our emerging understanding of the role of lncRNAs in an epigenetic silencing mechanism that is conserved across the higher eukaryotes. This proposal is directly relevant to the Horizon 2020 Work Programme goals: developing my creative potential and diversifying competences through international mobility and advanced training in technical and transferable skills; enhancing contact networks for both myself and my host organization through academic, commercial and public engagement; and catalysing significant career development.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "UNRAVEL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "UNRAVEL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More