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Ubl-Code SIGNED

Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease

Total Cost €

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EC-Contrib. €

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Partnership

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 Ubl-Code project word cloud

Explore the words cloud of the Ubl-Code project. It provides you a very rough idea of what is the project "Ubl-Code" about.

uses    pathogenesis    profoundly    cancer    dynamic    ms    vitro    analyze    operate    determined    aberrations    regulatory    modifying    vivo    function    signalling    substrates    remained    recognition    therapeutics    conjugation    underlying    protein    machinery    basis    monitor    acid    localization    code    rely    downstream    decipher    questions    edge    amino    initiate    broadly    reveal    ample    cellular    cell    ptm    genomic    enzymatic    mechanisms    landscape    cutting    appropriate    revealing    stability    understand    network    modified    ptms    deciphering    enzymes    proteins    technologies    shown    opportunity    relatively    paradigm    events    regulate    throughput    principles    decade    variety    molecular    tool    division    modifications    elucidate    proteomic    imaging    regulation    specificity    subsequent    translational    backbone    form    utilize    dynamics    sequence    characterization    progression    implicated    post    biological    diseases    unexplored    broadened    ubiquitin    substrate    profiling    fundamental    transcriptional    ubl    differentiation    specify   

Project "Ubl-Code" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Post-translational modifications (PTMs) of proteins are a major tool that the cell uses to monitor events and initiate appropriate responses. While a protein is defined by its backbone of amino acid sequence, its function is often determined by PTMs, which specify stability, activity, or cellular localization. Among PTMs, ubiquitin and ubiquitin-like (Ubl) modifications were shown to regulate a variety of fundamental cellular processes such as cell division and differentiation. Aberrations in these pathways have been implicated in the pathogenesis of cancer. Over the past decade high-throughput genomic and transcriptional analyses have profoundly broadened our understanding of the processes underlying cancer development and progression. Yet, proteomic analyses and the PTM landscape in cancer, remained relatively unexplored. Our goal is to decipher molecular mechanisms of Ubl regulation in cancer. We will utilize the PTM profiling technology that I developed and further develop it to allow for subsequent MS analysis. Together with cutting-edge genomic, imaging and proteomic technologies, we will analyze novel aspects of PTM regulation at the level of the enzymatic machinery, the substrates and the downstream cellular network. We will rely on ample in-vitro and in-vivo characterization of Ubl conjugation to:a. Elucidate the regulatory principles of substrate specificity and recognition. b. Understand signalling dynamics in the ubiquitin system. c. Reveal how aberrations in these pathways may lead to diseases such as cancer. Identifying both the Ubl modifying enzymes and the modified substrates will form the basis for deciphering the molecular pathways in which they operate in the cell and the principles of their dynamic regulation. Revealing the PTM regulatory code presents a unique opportunity for the development of novel therapeutics. More broadly, our approaches may provide a new paradigm for addressing other complex biological questions involving PTM regulation.

 Publications

year authors and title journal last update
List of publications.
2018 Hila Wolf-Levy, Aaron Javitt, Avital Eisenberg-Lerner, Assaf Kacen, Adi Ulman, Daoud Sheban, Bareket Dassa, Vered Fishbain-Yoskovitz, Carmelo Carmona-Rivera, Matthias P Kramer, Neta Nudel, Ifat Regev, Liron Zahavi, Dalia Elinger, Mariana J Kaplan, David Morgenstern, Yishai Levin, Yifat Merbl
Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides
published pages: 1110-1116, ISSN: 1087-0156, DOI: 10.1038/nbt.4279
Nature Biotechnology 36/11 2019-06-05
2017 Avital Eisenberg-Lerner, Ifat Regev, Yifat Merbl
Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation
published pages: 139-152, ISSN: , DOI: 10.1007/978-1-4939-7201-2_9
Methods in Molecular Biology 2019-06-19
2016 Avital Eisenberg-Lerner, Aaron Ciechanover, Yifat Merbl
Post-translational modification profiling – A novel tool for mapping the protein modification landscape in cancer
published pages: 1475-1482, ISSN: 1535-3702, DOI: 10.1177/1535370216651732
Experimental Biology and Medicine 241/14 2019-06-19

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