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SYNAPLAST MR SIGNED

Imaging synaptic plasticity by ultra-high field magnetic resonance spectroscopy in health and psychiatric disease

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EC-Contrib. €

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 SYNAPLAST MR project word cloud

Explore the words cloud of the SYNAPLAST MR project. It provides you a very rough idea of what is the project "SYNAPLAST MR" about.

stratification    13c    monitoring    intervention    syndrome    31p    plasticity    ptsd    depressive    treatment    autism    hyperactivity    parallel    lack    psychiatric    patient    bipolar    therapy    principles    obtaining    acute    stress    disease    entire    stimuli    subtypes    body    correction    brain    energy    membrane    mdd    chronic    compulsive    regard    concentrations    differential    depression    steady    anxiety    encoding    functional    addiction    image    magnetic    patients    stabilization    metabolite    metabolic    investigation    human    resonance    diagnostics    b0    disorders    neurotransmission    schizophrenia    search    imaging    deficit    data    contrasts    resolved    bd    pharmacological    reconstruction    primary    temporally    1h    posttraumatic    exploited    diagnosis    synaptic    reveal    hence    criteria    mri    transmission    quality    advantages    suggests    ocd    fourier    motion    adhs    time    innovative    spectroscopic    progression    shimming    ultimate    methodology    disorder    metabolism    environmental    biomarkers    obsessive   

Project "SYNAPLAST MR" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.kyb.tuebingen.mpg.de/mr-spektroskopie-ultra-hochfeld-methodologie
 Total cost 1˙505˙000 €
 EC max contribution 1˙505˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙505˙000.00

Map

 Project objective

A large number of psychiatric disorders (major and bipolar depression (MDD / BD), schizophrenia, obsessive-compulsive disorder (OCD), addiction, anxiety, attention deficit hyperactivity syndrome (ADHS), posttraumatic stress disorder (PTSD), autism) lack objective criteria for primary diagnosis, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring. Hence, the search for relevant biomarkers is of high importance. This proposal suggests the development of novel methodology for highly spatially and temporally resolved imaging of disease effects on neurotransmission, membrane processes related to synaptic plasticity and brain energy metabolism in psychiatric disorders and the acute and chronic impact of related pharmacological treatment in the human brain. To that, the advantages of a unique 9.4 T whole body human magnetic resonance imaging (MRI) system for 1H, 31P and 13C magnetic resonance spectroscopic imaging shall be exploited. Highly innovative enabling MRI technology including parallel transmission, very high order B0 shimming, a real time field stabilization and motion correction approach along with the principles of advanced encoding and non-Fourier image reconstruction shall ensure high data quality. Next to obtaining 20 novel image contrasts based on steady state metabolite concentrations, the ultimate goal of the proposed research is to enable functional spectroscopic imaging in the entire human brain in order to investigate adaptation of neurotransmission and brain metabolism to environmental stimuli as well as the impact of acute pharmacological intervention. Finally, the spatially and temporally resolved metabolic imaging technology shall be used for investigation of patients with major depressive disorder to reveal novel biomarkers relevant for diagnostics and patient stratification.

 Publications

year authors and title journal last update
List of publications.
2018 Sahar Nassirpour, Paul Chang, Anke Henning
MultiNet PyGRAPPA: A Novel Method for Highly Accelerated Metabolite Mapping
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2018 Sahar Nassirpour, Paul Chang, Anke Henning
Over-discretized SENSE reconstruction and B0 correction for accelerated non-lipidsuppressed 1H FID MRSI of the human brain at 9.4T
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2018 Theresia Ziegs, Anke Henning
Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra with differentPulse Sequences at 9.4 T
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2018 Sahar Nassirpour, Paul Chang, Thomas Kirchner, Anke Henning
Over-discretized SENSE reconstruction and B 0 correction for accelerated non-lipid-suppressed 1 H FID MRSI of the human brain at 9.4 T
published pages: e4014, ISSN: 0952-3480, DOI: 10.1002/nbm.4014
NMR in Biomedicine 31/12 2019-06-19
2018 Sahar Nassirpour, Paul Chang, Anke Henning
Whole Brain High Resolution Metabolite Mapping Using 1H FID MRSI with Slice-wise B0Shim Updating at 9.4T
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2018 Andrew Martin Wright, Sahar Nassirpour, Paul Chang, Anke Henning
Toward Absolute Quantification Using External Reference Standards at 3T and 9.4T
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2017 Ioannis-Angelos Giapitzakis, Nikolai Avdievitch, Saipavitra Murali Manohar, Nicole Fichtner , Roland Kreis, Anke Henning
Functional Magnetic Resonance Spectroscopy (fMRS) using metabolite cycled semi-LASER at9.4T: a pilot study
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-06-19
2018 Sahar Nassirpour, Paul Chang, Anke Henning
MultiNet PyGRAPPA: Multiple neural networks for reconstructing variable density GRAPPA (a 1H FID MRSI study)
published pages: 336-345, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.08.032
NeuroImage 183 2019-06-19
2018 Sahar Nassirpour, Paul Chang, Nikolai Avdievitch, Anke Henning
SNR Requirements for Successful Application of Compressed Sensing Acceleration toNon-lipid suppressed 1H MRSI at Ultra-High Fields
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2018 Ole Geldschlaeger, Tingting Shao, Anke Henning
Universal Parallel Transmit Pulse Design for Local Excitation
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-06-19
2017 Tingting Shao, Yun Zhang, Nikolai I. Avdievich, Christian Mirkes, Klaus Scheffler, Steffen Glaser, Anke Henning
Homogeneous high-flip-angle 3D localization by parallel transmission at 9.4T
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-06-19
2019 Ole Geldschlaeger, Saipavitra Muralio Manohar, Andrew Martin Wright, Nikolai I. Avdievich, Anke Henning
First MRI of the human spinal cord at 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-05-27
2018 Sahar Nassirpour, Paul Chang, Anke Henning
High and ultra-high resolution metabolite mapping of the human brain using 1 H FID MRSI at 9.4T
published pages: 211-221, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.12.065
NeuroImage 168 2019-03-12
2019 Ole Geldschlaeger, Saipavitra Muralio Manohar, Andrew Martin Wright, Nikolai I. Avdievich, Anke Henning
First MRI of the Human Spinal Cord at 9.4T.
published pages: , ISSN: , DOI:
ISMRM workshop on Ultrahigh Field Magnetic Resonance: Technological Advances, Translational Research Promises and Clinical Applications 2019 2019-03-18
2018 Patrik Oliver Wyss, Peter Zweers, Anne Brust A, Christian Funk, Michael Berger, Anke Henning.
Magnetic Resonance Spectroscopy biomarkers predict patient outcome in subacute spinal cord injury.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-03-18
2019 Johanna Dorst, Wolfgang Bogner, Loreen Ruhm, Nikolai I. Avdievich, Anke Henning.
ISIS-Localized 31P MR Spectroscopy in the Human Brain at 9.4T Reveals Inorganic Phosphate Signal Split.
published pages: , ISSN: , DOI:
ISMRM workshop on Ultrahigh Field Magnetic Resonance: Technological Advances, Translational Research Promises and Clinical Applications 2019 2019-03-18
2019 Nikolai I. Avdievich, Loreen Ruhm, Johanna Dorst, Anke Henning
Double-Tuned 31P/1H Human Head Array with High Performance at Both Frequencies for Chemical Shift Spectroscopic Imaging (CSI) at 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-03-18
2017 Yu-Chun (Paul) Chang, Sahar Nassirpour, Anke Henning
Fast non-water suppressed metabolite cycled 1H FID MRSI at both 3T and 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-03-12
2017 Sahar Nassirpour, Paul Chang, Nikolai I. Avdievich, Anke Henning
Multi-slice metabolite mapping with Very-High Degree Dynamic B0 Shim Updating at 9.4T using Accelerated 1H FID MRSI.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-03-12
2016 Sahar Nassirpour, Yu-Chun (Paul) Chang, Ariane Fillmer, Anke Henning
A Comparison of Optimization Algorithms for Localized In-Vivo Shimming
published pages: , ISSN: , DOI:
ISMRM Workshop on MR Spectroscopy: From Current Best Practice to Latest Frontiers 2016 2019-03-12
2017 Ioannis Angelos Giapitzakis, Nicole Fichtner, Daniel Zaldivar, Nikolai I. Avdievich, Saipavitra Murali-Manohar, Roland Kreis, Anke Henning.
Simultaneous detection of water and metabolites alternations under visual stimulation in human visual cortex utilizing metabolite cycled semi-LASER at 9.4T: preliminary results.
published pages: , ISSN: , DOI:
Proceedings of the 33rd Annual Scientific Meeting ESMRMB 2019-03-18
2019 Nikolai I. Avdievich, Loreen Ruhm, Klaus Scheffler, Anke Henning.
Novel 9.4T Head Array Provides for High Transmit Performance & Central SNR Improvement: Experimental Validation of UISNR Theory.
published pages: , ISSN: , DOI:
ISMRM workshop on Ultrahigh Field Magnetic Resonance: Technological Advances, Translational Research Promises and Clinical Applications 2019 2019-03-18
2019 Loreen Ruhm, Johanna Dorst, Nikolai I. Avdievich, Anke Henning
High-Resolved nOe-Enhanced 31 P MRSI of the Human Brain at 9.4T.
published pages: , ISSN: , DOI:
ISMRM workshop on Ultrahigh Field Magnetic Resonance: Technological Advances, Translational Research Promises and Clinical Applications 2019 2019-03-18
2016 Yu-Chun (Paul) Chang, Sahar Nassirpour, Anke Henning.
Very High-Order B0 Shimming for Proton MRSI at 9.4T.
published pages: , ISSN: , DOI:
ISMRM workshop on MR Spectroscopy: from current best practice to latest frontiers 2016 2019-03-12
2019 Patrik O. Wyss, Eveline Huber, Armin Curt, Spyros Kollias, Patrick Freund, Anke Henning
MR Spectroscopy of the Cervical Spinal Cord in Chronic Spinal Cord Injury
published pages: 181037, ISSN: 0033-8419, DOI: 10.1148/radiol.2018181037
Radiology 2019-03-12
2017 Sahar Nassirpour, Yu-Chun (Paul) Chang, Anke Henning
Comparison of different acceleration methods for high-resolution metabolite mapping using 1H FID MRSI at 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-03-12
2019 Andrew Martin Wright, Saipavitra Murali Manohar, Anke Henning
Relaxation corrected and Sequence-dependent Macromolecule Baseline Model.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-03-12
2019 Ole Geldschlaeger, Tingting Shao, Anke Henning.
Universal Parallel Transmit Pulse Design for 3-Dimensional Local-Excitation: A 9.4T Simulation Study.
published pages: , ISSN: , DOI:
ISMRM workshop on Ultrahigh Field Magnetic Resonance: Technological Advances, Translational Research Promises and Clinical Applications 2019 2019-03-12
2018 Yu-Chun (Paul) Chang, Sahar Nassirpour, Anke Henning
Highly Accelerated (R=14) Water Reference Acquisition for High Resolution 1H MRSI using Compressed Sensing.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-03-12
2017 Sahar Nassirpour, Yu-Chun (Paul) Chang, Anke Henning
High resolution maps of individual macromolecule components in the human brain at 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-03-12
2017 Sahar Nassirpour, Yu-Chun (Paul) Chang, Anke Henning.
Neural network based GRAPPA reconstruction for highly acclerated non lipid suppressed 1H FID MRSI at 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the 33rd Annual Scientific Meeting ESMRMB 2019-03-12
2016 Tingting Shao, Yen Zhang, Nikolai I. Avdievich, Steffen Glaser, Anke Henning
Parallel Transmission in 1H MR Spectroscopic Imaging at 9.4T.
published pages: , ISSN: , DOI:
ISMRM workshop on MR Spectroscopy: from current best practice to latest frontiers 2016 2019-03-18
2017 Sahar Nassirpour, Yu-Chun (Paul) Chang, Anke Henning
Pushing the limits of ultra-high field MRSI: benefits and limitations of 9.4T for metabolite mapping of the human brain.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-03-18
2018 Patrik O. Wyss, Claudio Bianchini, Milan Scheidegger, Ioannis A. Giapitzakis, Andreas Hock, Alexander Fuchs, Anke Henning
In vivo estimation of transverse relaxation time constant (T 2 ) of 17 human brain metabolites at 3T
published pages: 452-461, ISSN: 0740-3194, DOI: 10.1002/mrm.27067
Magnetic Resonance in Medicine 80/2 2019-03-12
2018 Ioannis-Angelos Giapitzakis, Nikolai Avdievich, Anke Henning
Characterization of macromolecular baseline of human brain using metabolite cycled semi-LASER at 9.4T
published pages: 462-473, ISSN: 0740-3194, DOI: 10.1002/mrm.27070
Magnetic Resonance in Medicine 80/2 2019-03-12
2018 Patrik Oliver Wyss, Eve Huber, Patrick Freund, Anke Henning
Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-03-18
2016 Patrik Oliver Wyss, Anke Henning, Andreas Hock, Niklaus Zoelch, Andreas Lutterotti, Roland Martin, Spyros S. Kollias
Alteration of Small Concentration Brain Metabolites at 3T in the Normal Appearing White Matter of Multiple Sclerosis (MS) Patients
published pages: , ISSN: , DOI:
ISMRM workshop on MR Spectroscopy: from current best practice to latest frontiers 2016 2019-03-18
2019 Ole Geldschlaeger, Tingting Shao, Anke Henning.
Universal Parallel Transmit Pulse Design for 3-Dimensional Local-Excitation: A 9.4T Simulation Study.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-03-18
2016 Yu-Chun (Paul) Chang, Sahar Nassirpour, Anke Henning
Very High-Order B0 Shimming for Ultra-High Field Magnetic Resonance.
published pages: , ISSN: , DOI:
ISMRM workshop on MR Spectroscopy: from current best practice to latest frontiers 2016 2019-03-12
2016 Sahar Nassirpour, Yu-Chun (Paul) Chang, Anke Henning
Metabolite Mapping of the Human Brain Using 1H FID MRSI at 9.4T.
published pages: , ISSN: , DOI:
ISMRM workshop on MR Spectroscopy: from current best practice to latest frontiers 2016 2019-03-12
2018 Ioannis-Angelos Giapitzakis, Tingting Shao, Nikolai Avdievich, Ralf Mekle, Roland Kreis, Anke Henning
Metabolite-cycled STEAM and semi-LASER localization for MR spectroscopy of the human brain at 9.4T
published pages: 1841-1850, ISSN: 0740-3194, DOI: 10.1002/mrm.26873
Magnetic Resonance in Medicine 79/4 2019-03-12
2018 Sahar Nassirpour, Paul Chang, Nikolai Avdievitch, Anke Henning
Compressed sensing for high-resolution nonlipid suppressed 1 H FID MRSI of the human brain at 9.4T
published pages: 2311-2325, ISSN: 0740-3194, DOI: 10.1002/mrm.27225
Magnetic Resonance in Medicine 80/6 2019-03-12
2019 Johanna Dorst, Loreen Ruhm, Nikolai I. Avdievich, Wolfgang Bogner, Anke Henning.
31P Single Voxel MRS in the Human Brain at 9.4T: ISIS versus SemiLASER.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-03-12
2018 Yu-Chun (Paul) Chang, Sahar Nassirpour, Ali Aghaeifar, Klaus Scheffler, Anke Henning
Dynamic B0 Shimming for Multi-Slice Metabolite Mapping at Ultra-High Field in the Human Brain: Very High Order Spherical Harmonics vs. Multi-Coil.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2018 2019-03-12
2018 Ioannis‐Angelos Giapitzakis, Tamas Borbath, Saipavitra Murali‐Manohar, Nikolai Avdievich, Anke Henning
Investigation of the influence of macromolecules and spline baseline in the fitting model of human brain spectra at 9.4T
published pages: 746-758, ISSN: 0740-3194, DOI: 10.1002/mrm.27467
Magnetic Resonance in Medicine 81/2 2019-03-12
2017 Ioannis-Angelos Giapitzakis, Tingting Shao, Nikolai I. Avdievitch, Nicole Fichtner, Ralf Mekle, Roland Kreis, Anke Henning
Metabolite cycled semi-LASER and STEAM at 9.4T. Comparison and in vivo results.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2017 2019-03-12
2019 Loreen Ruhm, Johanna Dorst, Nikolai I. Avdievich, Andrew Martin Wright, Chris Mirkes, Jonas Bause, Klaus Scheffler, Anke Henning
31P MRSI of the human brain at 9.4 T: Metabolic imaging applying low-rank denoising.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-03-12
2019 Andrew Martin Wright, Saipavitra Murali Manohar, Tamas Borbath, Anke Henning.
Longitudinal Relaxation Times of Metabolites in vivo at 9.4 T.
published pages: , ISSN: , DOI:
Proceedings of the International Society of Magnetic Resonance in Medicine 2019 2019-03-18
2017 Sahar Nassirpour, Yu-Chun (Paul) Chang, Anke Henning.
Over-discrete SENSE and B0 correction for highly accelerated 1H FID MRSI of the human brain at 9.4T.
published pages: , ISSN: , DOI:
Proceedings of the 33rd Annual Scientific Meeting ESMRMB 2019-03-12
2018 Anke Henning
Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review
published pages: 181-198, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.07.017
NeuroImage 168 2019-03-12
2016 Ioannis-Angelos Giapitzakis, Roland Kreis, Anke Henning.
Metabolite Cycled Semi-LASER in Human Brain at 9.4T: In Vivo Results.
published pages: , ISSN: , DOI:
ISMRM workshop on MR Spectroscopy: from current best practice to latest frontiers 2016 2019-03-18

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