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INVADIS SIGNED

Microbial invasion and dissemination within the host, mechanisms and effects

Total Cost €

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EC-Contrib. €

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Partnership

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 INVADIS project word cloud

Explore the words cloud of the INVADIS project. It provides you a very rough idea of what is the project "INVADIS" about.

basic    scientific    liver    clinical    physiologically    pathogenesis    causative    invasion    actual    questions    cell    intestinal    model    critical    implications    unprecedented    microbes    caused    exclusive    disseminates    genetically    spleen    pathogens    physiology    fetoplacental    live    listeriosis    replicates    microorganism    immune    health    reveals    mouse    remarkable    crosses    an    organoids    systemic    combination    biomedical    understand    significance    complexity    embrace    microbial    decipher    experimental    tropisms    biodiversity    listeria    mucosal    barrier    patients    entry    mechanisms    harness    biology    engineered    cns    deleterious    infections    central    integrative    molecular    stem    offers    monocytogenes    infection    predisposing    lm    reductionist    shared    foodborne    human    stands    900    imaging    tissue    innovative    host    nervous    cohort    systemically    models    data    translocation    virulence    epithelium    discover    reveal    biological    guided    building    pathogen    strains    journey    fate    medical    invasive    portal    corresponding    hosts    interactions   

Project "INVADIS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://research.pasteur.fr/fr/project/erc-2015-cog-invadis/
 Total cost 2˙750˙000 €
 EC max contribution 2˙750˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 2˙750˙000.00

Map

 Project objective

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way forward to address basic biological questions and improve health. We study listeriosis, a systemic infection caused by Listeria monocytogenes (Lm). Lm is a human foodborne pathogen that crosses the intestinal barrier, disseminates systemically, replicates in liver and spleen and reaches the central nervous system (CNS) and fetoplacental unit. Given the remarkable journey Lm makes in its host, studying listeriosis offers unprecedented opportunities to understand host cell biology, physiology and immune responses, guided by Lm. The mucosal, CNS and fetoplacental tropisms of Lm are shared by other microbes which pathogenesis is far less understood. Lm therefore stands as a unique model microorganism of general biological and medical significance. The major challenge of this project is to go beyond reductionist approaches and embrace the complexity of actual infections. We will use stem cell-derived organoids, live imaging, genetically engineered mouse models, the clinical and biological data from a unique cohort of 900 patients and the corresponding causative Lm strains, to investigate the molecular mechanisms of Lm tissue invasion, dissemination and host responses. Specifically, we will (i) decipher the cell biology of microbial translocation across the intestinal epithelium; (ii) study the impact of microbial portal of entry on microbial fate, dissemination and host responses; (iii) harness Lm biodiversity to identify novel virulence factors and (iv) discover new host factors predisposing to invasive infections. Building on the unique combination of advanced experimental systems and exclusive clinical data, this integrative and innovative project will reveal novel, physiologically relevant mechanisms of infection, with scientific and biomedical implications.

 Publications

year authors and title journal last update
List of publications.
2016 Mylène M Maury, Yu-Huan Tsai, Caroline Charlier, Marie Touchon, Viviane Chenal-Francisque, Alexandre Leclercq, Alexis Criscuolo, Charlotte Gaultier, Sophie Roussel, Anne Brisabois, Olivier Disson, Eduardo P C Rocha, Sylvain Brisse, Marc Lecuit
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
published pages: 308-313, ISSN: 1061-4036, DOI: 10.1038/ng.3501
Nature Genetics 48/3 2019-08-29
2018 Olivier Disson, Camille Blériot, Jean-Marie Jacob, Nicolas Serafini, Sophie Dulauroy, Grégory Jouvion, Cindy Fevre, Grégoire Gessain, Pierre Thouvenot, Gérard Eberl, James P. Di Santo, Lucie Peduto, Marc Lecuit
Peyer’s patch myeloid cells infection by Listeria signals through gp38 + stromal cells and locks intestinal villus invasion
published pages: 2936-2954, ISSN: 0022-1007, DOI: 10.1084/jem.20181210
The Journal of Experimental Medicine 215/11 2019-09-04
2019 Mylène M. Maury, Hélène Bracq-Dieye, Lei Huang, Guillaume Vales, Morgane Lavina, Pierre Thouvenot, Olivier Disson, Alexandre Leclercq, Sylvain Brisse, Marc Lecuit
Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10380-0
Nature Communications 10/1 2019-09-02
2017 Mylène M. Maury, Viviane Chenal-Francisque, Hélène Bracq-Dieye, Lei Han, Alexandre Leclercq, Guillaume Vales, Alexandra Moura, Edith Gouin, Mariela Scortti, Olivier Disson, José A. Vázquez-Boland, Marc Lecuit
Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes
published pages: , ISSN: 0019-9567, DOI: 10.1128/iai.00541-17
Infection and Immunity 85/11 2019-09-02

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