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Adaptive Optical Microscopy Systems: Unifying theory, practice and applications

Total Cost €


EC-Contrib. €






 AdOMiS project word cloud

Explore the words cloud of the AdOMiS project. It provides you a very rough idea of what is the project "AdOMiS" about.

individual    observation    toolkit    types    technological    suffer    unprecedented    optics    scientific    algorithms    permit    bespoke    operation    generation    diverse    shown    creation    promise    fundamental    central    specimen    imaging    engineering    environment    optimal    demonstrations    coupled    possibilities    adaptive    molecular    microscopy    commercial    encompasses    made    structures    dynamics    fluorescence    place    routine    caused    enabled    broadened    tie    limits    optimum    directed    microscope    sensitivity    variations    software    theoretical    resolution    correcting    capability    broad    index    rely    fidelity    diversity    labeling    shows    solutions    designs    outputs    met    biomedical    recent    vastly    practical    progress    microscopes    tool    virtually    limitations    tools    efficiency    ao    frameworks    additional    translatable    refractive    suite    accepted    optical    biological    tissue    investigation    sciences    aberrations    overcome    prevents    cellular    protocols   

Project "AdOMiS" data sheet

The following table provides information about the project.


Organization address
city: OXFORD
postcode: OX1 2JD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙234˙789 €
 EC max contribution 3˙234˙789 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and processes with unprecedented sensitivity and resolution. This work has been enabled by the engineering development of diverse optical systems that provide different capabilities for the imaging toolkit. All such methods rely upon high fidelity optics to provide optimal resolution and efficiency, but they all suffer from aberrations caused by refractive index variations within the specimen. It is widely accepted that in many applications this fundamental problem prevents optimum operation and limits capability. Adaptive optics (AO) has been introduced to overcome these limitations by correcting aberrations and a range of demonstrations has shown clearly its potential. Indeed, it shows great promise to improve virtually all types of research or commercial microscopes, but significant challenges must still be met before AO can be widely implemented in routine imaging. Current advances are being made through development of bespoke AO solutions to individual imaging tasks. However, the diversity of microscopy methods means that individual solutions are often not translatable to other systems. This proposal is directed towards the creation of theoretical and practical frameworks that tie together AO concepts and provide a suite of scientific tools with broad application. This will be achieved through a systems approach that encompasses theoretical modelling, optical engineering and the requirements of biological applications. Additional outputs will include practical designs, operating protocols and software algorithms that will support next generation AO microscope systems.


year authors and title journal last update
List of publications.
2019 Mantas Žurauskas, Ian M. Dobbie, Richard M. Parton, Mick A. Phillips, Antonia Göhler, Ilan Davis, Martin J. Booth
IsoSense: frequency enhanced sensorless adaptive optics through structured illumination
published pages: 370, ISSN: 2334-2536, DOI: 10.1364/optica.6.000370
Optica 6/3 2019-09-04
2019 Raphaël Turcotte, Carla C. Schmidt, Nigel J. Emptage, Martin J. Booth
Focusing light in biological tissue through a multimode optical fiber: refractive index matching
published pages: 2386, ISSN: 0146-9592, DOI: 10.1364/ol.44.002386
Optics Letters 44/10 2019-09-04
2019 Yuanyuan Dai, Jacopo Antonello, Martin J. Booth
Calibration of a phase-only spatial light modulator for both phase and retardance modulation
published pages: 17912, ISSN: 1094-4087, DOI: 10.1364/oe.27.017912
Optics Express 27/13 2019-09-04
2017 Bangshan Sun, Patrick S Salter, Clemens Roider, Alexander Jesacher, Johannes Strauss, Johannes Heberle, Michael Schmidt, Martin J Booth
Four-dimensional light shaping: manipulating ultrafast spatiotemporal foci in space and time
published pages: 17117, ISSN: 2047-7538, DOI: 10.1038/lsa.2017.117
Light: Science & Applications 7/1 2019-06-13
2017 Xiang Hao, Jacopo Antonello, Edward S. Allgeyer, Joerg Bewersdorf, Martin J. Booth
Aberrations in 4Pi Microscopy
published pages: 14049, ISSN: 1094-4087, DOI: 10.1364/OE.25.014049
Optics Express 25/13 2019-06-13
2017 Mantas Žurauskas, Oliver Barnstedt, Maria Frade-Rodriguez, Scott Waddell, Martin J. Booth
Rapid adaptive remote focusing microscope for sensing of volumetric neural activity
published pages: 4369, ISSN: 2156-7085, DOI: 10.1364/BOE.8.004369
Biomedical Optics Express 8/10 2019-06-13
2018 Bing Dong, Martin J. Booth
Wavefront control in adaptive microscopy using Shack-Hartmann sensors with arbitrarily shaped pupils
published pages: 1655, ISSN: 1094-4087, DOI: 10.1364/OE.26.001655
Optics Express 26/2 2019-06-13

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