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An interdisciplinary approach to uncover the mechanisms of progression of cartilage damage at the cellular and tissue levels

Total Cost €


EC-Contrib. €






 INpaCT project word cloud

Explore the words cloud of the INpaCT project. It provides you a very rough idea of what is the project "INpaCT" about.

frequent    loading    biomechanics    healing    mechanobiological    structural    oa    massachusetts    cells    organization    pathological    international    osteoarthritis    finland    eastern    group    techniques    patients    prevent    people    expertise    model    reduce    dr    modeling    novelty    tissue    composition    generally    heal    cambridge    opportunity    damage    gene    strategies    vitro    shed    combining    microscopic    mechanics    biochemistry    levels    health    scales    time    skill    molecular    degeneration    beneficial    prof    sophisticated    injury    cell    healthy    light    function    korhonen    data    carefully    ultimately    length    grodzinsky    computational    expression    young    disease    excessive    biology    spectroscopic    mechanical    mechanisms    lies    kuopio    seldom    interdisciplinary    mutually    cartilage    materials    joint    post    florea    university    precise    assumed    accelerate    complementary    usa    mount    relationships    progression    structure    injuries   

Project "INpaCT" data sheet

The following table provides information about the project.


Organization address
city: KUOPIO
postcode: 70211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 267˙793 €
 EC max contribution 267˙793 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-08-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 267˙793.00


 Project objective

Joint injuries are very frequent, especially among young people. Such injuries seldom heal and over time can lead to cartilage degeneration and ultimately osteoarthritis. Although, it is generally assumed that excessive mechanical loading post-injury can cause or accelerate the progression of cartilage degeneration, the precise mechanisms involved in the pathological processes at different structural length scales are still not fully understood. Thus, novel approaches for understanding structure-function relationships from the cell to tissue level in both health and disease are necessary. The overall aim of this research is to investigate the mechanisms of cartilage damage progression at different levels of tissue organization. The novelty of this research lies in the highly interdisciplinary approach of combining an in vitro model of OA progression with the state-of-the-art materials testing devices, computational modeling and sophisticated microscopic, spectroscopic and molecular biology techniques to carefully assess the mechanics, structure, composition and gene expression on cell and tissue levels. The novel data obtained from this research will shed light on the key mechanobiological pathways by which cartilage cells maintain healthy tissue or mount a healing response following tissue injury and excessive loading. This project is conducted as an international collaboration between University of Eastern Finland, Kuopio, Finland and Massachusetts Institute of Technology, Cambridge, USA. This represents a unique opportunity to bring together the complementary skill sets of Dr. Florea, Dr. Korhonen’s group and Prof. Grodzinsky’s group, with their expertise in biomechanics, computational modeling, biochemistry and cartilage biology. The mutually beneficial collaboration between Europe and USA can advance the field of cartilage research with significant potential to provide novel strategies to reduce/prevent cartilage degeneration for patients in Europe and beyond.

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The information about "INPACT" are provided by the European Opendata Portal: CORDIS opendata.

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