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An interdisciplinary approach to uncover the mechanisms of progression of cartilage damage at the cellular and tissue levels

Total Cost €


EC-Contrib. €






 INpaCT project word cloud

Explore the words cloud of the INpaCT project. It provides you a very rough idea of what is the project "INpaCT" about.

mechanisms    tissue    generally    mechanics    heal    mount    prevent    time    frequent    mechanical    precise    damage    eastern    novelty    finland    techniques    opportunity    accelerate    injuries    spectroscopic    degeneration    cambridge    mechanobiological    structural    cell    materials    seldom    international    structure    kuopio    complementary    carefully    lies    joint    composition    people    healthy    grodzinsky    excessive    post    length    scales    function    mutually    dr    combining    vitro    assumed    beneficial    biology    gene    massachusetts    skill    shed    patients    light    group    prof    biochemistry    reduce    florea    health    expression    organization    university    expertise    microscopic    cartilage    computational    modeling    model    progression    strategies    ultimately    levels    data    loading    oa    healing    sophisticated    korhonen    osteoarthritis    injury    disease    molecular    usa    relationships    interdisciplinary    pathological    young    cells    biomechanics   

Project "INpaCT" data sheet

The following table provides information about the project.


Organization address
city: KUOPIO
postcode: 70211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 267˙793 €
 EC max contribution 267˙793 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-08-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 267˙793.00


 Project objective

Joint injuries are very frequent, especially among young people. Such injuries seldom heal and over time can lead to cartilage degeneration and ultimately osteoarthritis. Although, it is generally assumed that excessive mechanical loading post-injury can cause or accelerate the progression of cartilage degeneration, the precise mechanisms involved in the pathological processes at different structural length scales are still not fully understood. Thus, novel approaches for understanding structure-function relationships from the cell to tissue level in both health and disease are necessary. The overall aim of this research is to investigate the mechanisms of cartilage damage progression at different levels of tissue organization. The novelty of this research lies in the highly interdisciplinary approach of combining an in vitro model of OA progression with the state-of-the-art materials testing devices, computational modeling and sophisticated microscopic, spectroscopic and molecular biology techniques to carefully assess the mechanics, structure, composition and gene expression on cell and tissue levels. The novel data obtained from this research will shed light on the key mechanobiological pathways by which cartilage cells maintain healthy tissue or mount a healing response following tissue injury and excessive loading. This project is conducted as an international collaboration between University of Eastern Finland, Kuopio, Finland and Massachusetts Institute of Technology, Cambridge, USA. This represents a unique opportunity to bring together the complementary skill sets of Dr. Florea, Dr. Korhonen’s group and Prof. Grodzinsky’s group, with their expertise in biomechanics, computational modeling, biochemistry and cartilage biology. The mutually beneficial collaboration between Europe and USA can advance the field of cartilage research with significant potential to provide novel strategies to reduce/prevent cartilage degeneration for patients in Europe and beyond.

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The information about "INPACT" are provided by the European Opendata Portal: CORDIS opendata.

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