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INpaCT SIGNED

An interdisciplinary approach to uncover the mechanisms of progression of cartilage damage at the cellular and tissue levels

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INpaCT project word cloud

Explore the words cloud of the INpaCT project. It provides you a very rough idea of what is the project "INpaCT" about.

ultimately    florea    techniques    seldom    expertise    heal    degeneration    loading    osteoarthritis    massachusetts    grodzinsky    structure    pathological    strategies    eastern    healing    health    patients    scales    accelerate    oa    biomechanics    joint    relationships    dr    young    mechanics    injury    microscopic    group    computational    cartilage    generally    organization    carefully    opportunity    structural    biochemistry    damage    people    prevent    usa    time    injuries    prof    mutually    precise    assumed    kuopio    mechanisms    shed    light    composition    modeling    mechanobiological    gene    vitro    model    frequent    tissue    lies    expression    reduce    progression    finland    spectroscopic    cambridge    combining    biology    disease    complementary    novelty    healthy    korhonen    beneficial    university    skill    function    cell    international    mechanical    sophisticated    interdisciplinary    materials    levels    post    molecular    mount    length    excessive    data    cells   

Project "INpaCT" data sheet

The following table provides information about the project.

Coordinator
ITA-SUOMEN YLIOPISTO 

Organization address
address: YLIOPISTONRANTA 1 E
city: KUOPIO
postcode: 70211
website: www.uef.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 267˙793 €
 EC max contribution 267˙793 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-08-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 267˙793.00
2    MASSACHUSSETTS INSTITUTE OF TECHNOLOGY MIT CORPORATION US (CAMBRIDGE) partner 0.00

Map

 Project objective

Joint injuries are very frequent, especially among young people. Such injuries seldom heal and over time can lead to cartilage degeneration and ultimately osteoarthritis. Although, it is generally assumed that excessive mechanical loading post-injury can cause or accelerate the progression of cartilage degeneration, the precise mechanisms involved in the pathological processes at different structural length scales are still not fully understood. Thus, novel approaches for understanding structure-function relationships from the cell to tissue level in both health and disease are necessary. The overall aim of this research is to investigate the mechanisms of cartilage damage progression at different levels of tissue organization. The novelty of this research lies in the highly interdisciplinary approach of combining an in vitro model of OA progression with the state-of-the-art materials testing devices, computational modeling and sophisticated microscopic, spectroscopic and molecular biology techniques to carefully assess the mechanics, structure, composition and gene expression on cell and tissue levels. The novel data obtained from this research will shed light on the key mechanobiological pathways by which cartilage cells maintain healthy tissue or mount a healing response following tissue injury and excessive loading. This project is conducted as an international collaboration between University of Eastern Finland, Kuopio, Finland and Massachusetts Institute of Technology, Cambridge, USA. This represents a unique opportunity to bring together the complementary skill sets of Dr. Florea, Dr. Korhonen’s group and Prof. Grodzinsky’s group, with their expertise in biomechanics, computational modeling, biochemistry and cartilage biology. The mutually beneficial collaboration between Europe and USA can advance the field of cartilage research with significant potential to provide novel strategies to reduce/prevent cartilage degeneration for patients in Europe and beyond.

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The information about "INPACT" are provided by the European Opendata Portal: CORDIS opendata.

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