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MacroAutophagy and Necrotic Neurodegeneration in Ageing

Total Cost €


EC-Contrib. €






 MANNA project word cloud

Explore the words cloud of the MANNA project. It provides you a very rough idea of what is the project "MANNA" about.

longevity    flux    critically    nematode    functional    underpinnings    interrogate    ischemia    dissect    deepen    ranging    insights    imaging    lowly    lifespan    evolutionarily    poorly    human    nucleophagy    manipulations    mitophagy    mammalian    neurons    conservation    implicated    vivo    pathologies    roles    dietary    relevance    alter    first    taxa    susceptibility    genome    life    devastating    restriction    necrotic    declines    molecular    necrosis    determinant    power    caenorhabditis    fourfold    indicate    inflicted    govern    neuronal    age    combines    modifiers    mediators    modulation    elegans    multifaceted    monitor    igf1    vulnerability    pro    neurodegeneration    stroke    species    organellar    screens    genetics    autophagy    macroautophagy    organelle    induction    broad    neuron    signalling    pexophagy    insulin    survival    enhances    disorders    mechanisms    health    extend    contributes    quality    humans    microfluidics    death    conserved    cargo    versatility    models    ageing    fourth    conduct    diverse    neurodegenerative    autophagic    critical   

Project "MANNA" data sheet

The following table provides information about the project.


Organization address
address: N PLASTIRA STR 100
postcode: 70013

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website
 Total cost 2˙254˙109 €
 EC max contribution 2˙254˙109 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Necrosis contributes critically in devastating human pathologies such as stroke, ischemia, and age-associated neurodegenerative disorders. Ageing increases susceptibility to neurodegeneration, in diverse species ranging from the lowly nematode Caenorhabditis elegans to humans. The mechanisms that govern necrotic neurodegeneration and its modulation by ageing are poorly understood. Autophagy has been implicated in necrosis and neurodegeneration, both with pro-survival and a pro-death roles. Autophagic flux declines with age, while induction of autophagy enhances longevity under conditions such as low insulin/IGF1 signalling and dietary restriction, which extend lifespan across diverse taxa. Our recent findings indicate that organelle-specific autophagy, including mitophagy, pexophagy and nucleophagy, is an important, evolutionarily conserved, determinant of longevity. We propose to dissect the molecular underpinnings of neuron vulnerability to necrosis during ageing, focusing on cargo-specific macroautophagy. To this end, we will implement a multifaceted approach that combines the power and versatility of C. elegans genetics with advanced, in vivo neuronal imaging and microfluidics technology. Our objectives are fourfold. First, we will monitor autophagic flux of organellar cargo, during neurodegeneration, under conditions that alter lifespan and identify mediators of organelle-specific autophagy in neurons. Second, we will conduct genome-wide screens for modifiers of age-inflicted neurodegeneration. Third, we will interrogate nematode models of human neurodegenerative disorders for organelle-specific autophagy and susceptibility to necrosis, upon manipulations that alter lifespan. Fourth, we will investigate the functional conservation of key mechanisms in mammalian models of neuronal necrosis. Together, these studies will deepen our understanding of age-related neurodegeneration and provide critical insights with broad relevance to human health and quality of life.


year authors and title journal last update
List of publications.
2018 Maria Markaki, Konstantinos Palikaras, Nektarios Tavernarakis
Chapter Five - Novel Insights Into the Anti-aging Role of Mitophagy
published pages: 169-208, ISSN: 1937-6448, DOI: 10.1016/bs.ircmb.2018.05.005
International Review of Cell and Molecular Biology 2020-03-17
2018 Athanasios Metaxakis, Dionysia Petratou, Nektarios Tavernarakis
Multimodal sensory processing in Caenorhabditis elegans
published pages: 180049, ISSN: 2046-2441, DOI: 10.1098/rsob.180049
Open Biology 8/6 2020-03-17
2018 Andrea Princz, Konstantinos Kounakis, Nektarios Tavernarakis
Mitochondrial contributions to neuronal development and function
published pages: 723-739, ISSN: 1431-6730, DOI: 10.1515/hsz-2017-0333
Biological Chemistry 399/7 2020-03-17
2018 Ilias Gkikas, Konstantinos Palikaras, Nektarios Tavernarakis
The Role of Mitophagy in Innate Immunity
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01283
Frontiers in Immunology 9 2020-03-17
2017 Emmanouil Kyriakakis, Nikolaos Charmpilas, Nektarios Tavernarakis
Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05276-2
Scientific Reports 7/1 2020-03-17
2017 Konstantinos Palikaras, Ioanna Daskalaki, Maria Markaki, Nektarios Tavernarakis
Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover
published pages: 157-174, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2017.04.005
Pharmacology & Therapeutics 178 2020-03-17
2019 Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan, Paula Rocktäschel, Deborah L. Croteau, Mansour Akbari, Nigel H. Greig, Tormod Fladby, Hilde Nilsen, M. Zameel Cader, Mark P. Mattson, Nektarios Tavernarakis, Vilhelm A. Bohr
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
published pages: 401-412, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0332-9
Nature Neuroscience 22/3 2020-03-17
2019 Andrea Princz, Nektarios Tavernarakis
SUMOylation in Neurodegenerative Diseases
published pages: 1-9, ISSN: 0304-324X, DOI: 10.1159/000502142
Gerontology 2020-03-17
2018 Konstantinos Palikaras, Eirini Lionaki, Nektarios Tavernarakis
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
published pages: 1013-1022, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0176-2
Nature Cell Biology 20/9 2020-03-17
2019 Konstantinos Kounakis, Manos Chaniotakis, Maria Markaki, Nektarios Tavernarakis
Emerging Roles of Lipophagy in Health and Disease
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2019.00185
Frontiers in Cell and Developmental Biology 7 2020-03-17
2018 Ioanna Daskalaki, Ilias Gkikas, Nektarios Tavernarakis
Hypoxia and Selective Autophagy in Cancer Development and Therapy
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2018.00104
Frontiers in Cell and Developmental Biology 6 2020-03-17
2018 Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Regulation and Roles of Autophagy at Synapses
published pages: 646-661, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2018.03.006
Trends in Cell Biology 28/8 2020-03-17
2019 Margarita-Elena Papandreou, Nektarios Tavernarakis
Nucleophagy: from homeostasis to disease
published pages: 630-639, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0266-5
Cell Death & Differentiation 26/4 2020-03-17
2019 Guofeng Lou, Konstantinos Palikaras, Sofie Lautrup, Morten Scheibye-Knudsen, Nektarios Tavernarakis, Evandro F. Fang
Mitophagy and Neuroprotection
published pages: , ISSN: 1471-4914, DOI: 10.1016/j.molmed.2019.07.002
Trends in Molecular Medicine 2020-03-17
2018 Athanasios Metaxakis, Christina Ploumi, Nektarios Tavernarakis
Autophagy in Age-Associated Neurodegeneration
published pages: 37, ISSN: 2073-4409, DOI: 10.3390/cells7050037
Cells 7/5 2020-03-17
2019 Nikolaos Charmpilas, Nektarios Tavernarakis
Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans
published pages: , ISSN: 1350-9047, DOI: 10.1038/s41418-019-0375-9
Cell Death & Differentiation 2020-03-17
2018 Matthias Rieckher, Maria Markaki, Andrea Princz, Björn Schumacher, Nektarios Tavernarakis
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans
published pages: 199-211.e6, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.009
Cell Reports 25/1 2020-03-17

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