Explore the words cloud of the HP4all project. It provides you a very rough idea of what is the project "HP4all" about.
The following table provides information about the project.
UNIVERSITE LYON 1 CLAUDE BERNARD
|Coordinator Country||France [FR]|
|Total cost||1˙995˙000 €|
|EC max contribution||1˙995˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||UNIVERSITE LYON 1 CLAUDE BERNARD||FR (VILLEURBANNE CEDEX)||coordinator||1˙995˙000.00|
Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry. Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. Hyperpolarization (HP) in principle provides a solution to this limitation. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR. By physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated. These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation. This project will yield to a broadly applicable method revolutionizing analytical chemistry, drug discovery and medical diagnostics, and thereby will provide a powerful tool to solve challenges at the forefront of molecular and chemical sciences today.
|year||authors and title||journal||last update|
Alexey S. Kiryutin, Bogdan A. Rodin, Alexandra V. Yurkovskaya, Konstantin L. Ivanov, Dennis Kurzbach, Sami Jannin, David Guarin, Daniel Abergel, Geoffrey Bodenhausen
Transport of hyperpolarized samples in dissolution-DNP experiments
published pages: 13696-13705, ISSN: 1463-9076, DOI: 10.1039/c9cp02600b
|Physical Chemistry Chemical Physics 21/25||2019-08-30|
Sami Jannin, Jean-Nicolas Dumez, Patrick Giraudeau, Dennis Kurzbach
Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts
published pages: 41-50, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.06.001
|Journal of Magnetic Resonance 305||2019-08-30|
Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, AurÃ©lien Bornet, Arthur C. Pinon, Gabriele Stevanato, Benno Meier, Geoffrey Bodenhausen, Sami Jannin, Malcolm H. Levitt
Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups
published pages: 3549-3555, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.7b01512
|The Journal of Physical Chemistry Letters 8/15||2019-06-13|
Wolfram R. GrÃ¼ning, Harald Bieringer, Martin SchwarzwÃ¤lder, David Gajan, AurÃ©lien Bornet, Basile Vuichoud, Jonas Milani, David Baudouin, Laurent Veyre, Anne Lesage, Sami Jannin, Geoffrey Bodenhausen, ChloÃ© Thieuleux, Christophe CopÃ©ret
Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures
published pages: e1600122, ISSN: 0018-019X, DOI: 10.1002/hlca.201600122
|Helvetica Chimica Acta 100/1||2019-06-13|
X. Ji, T.V. Can, F. Mentink-Vigier, A. Bornet, J. Milani, B. Vuichoud, M.A. Caporini, R.G. Griffin, S. Jannin, M. Goldman, G. Bodenhausen
Overhauser effects in non-conducting solids at 1.2â€¯K
published pages: 138-142, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.11.017
|Journal of Magnetic Resonance 286||2019-06-13|
Xiao Ji, AurÃ©lien Bornet, Basile Vuichoud, Jonas Milani, David Gajan, Aaron J. Rossini, Lyndon Emsley, Geoffrey Bodenhausen, Sami Jannin
Transportable hyperpolarized metabolites
published pages: 13975, ISSN: 2041-1723, DOI: 10.1038/ncomms13975
|Nature Communications 8||2019-06-13|
Daniel L. Silverio, Henri A. van Kalkeren, Ta-Chung Ong, Mathieu Baudin, Maxim Yulikov, Laurent Veyre, Pierrick Berruyer, Sachin Chaudhari, David Gajan, David Baudouin, Matthieu CavaillÃ¨s, Basile Vuichoud, AurÃ©lien Bornet, Gunnar Jeschke, Geoffrey Bodenhausen, Anne Lesage, Lyndon Emsley, Sami Jannin, ChloÃ© Thieuleux, Christophe CopÃ©ret
Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls
published pages: e1700101, ISSN: 0018-019X, DOI: 10.1002/hlca.201700101
|Helvetica Chimica Acta 100/6||2019-06-13|
Mathieu Baudin, Basile Vuichoud, AurÃ©lien Bornet, Geoffrey Bodenhausen, Sami Jannin
A cryogen-consumption-free system for dynamic nuclear polarization at 9.4â€¯T
published pages: 115-121, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.07.001
|Journal of Magnetic Resonance 294||2019-06-13|
Stuart J. Elliott, Benno Meier, Basile Vuichoud, Gabriele Stevanato, Lynda J. Brown, Javier Alonso-Valdesueiro, Lyndon Emsley, Sami Jannin, Malcolm H. Levitt
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
published pages: 9755-9759, ISSN: 1463-9076, DOI: 10.1039/c8cp00253c
|Physical Chemistry Chemical Physics 20/15||2019-06-13|
Kirill V. Kovtunov, Ekaterina V. Pokochueva, Oleg G. Salnikov, Samuel F. Cousin, Dennis Kurzbach, Basile Vuichoud, Sami Jannin, Eduard Y. Chekmenev, Boyd M. Goodson, Danila A. Barskiy, Igor V. Koptyug
Hyperpolarized NMR Spectroscopy: d -DNP, PHIP, and SABRE Techniques
published pages: , ISSN: 1861-4728, DOI: 10.1002/asia.201800551
|Chemistry - An Asian Journal||2019-06-13|
Bertrand Plainchont, Pierrick Berruyer, Jean-Nicolas Dumez, Sami Jannin, Patrick Giraudeau
Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry
published pages: 3639-3650, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b05236
|Analytical Chemistry 90/6||2019-06-13|
Jonas Milani, Basile Vuichoud, AurÃ©lien Bornet, Roberto Melzi, Sami Jannin, Geoffrey Bodenhausen
Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization
published pages: 15109, ISSN: 0034-6748, DOI: 10.1063/1.4973777
|Review of Scientific Instruments 88/1||2019-06-13|
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