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HP4all SIGNED

Persistent and Transportable Hyperpolarization for Magnetic Resonance

Total Cost €

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EC-Contrib. €

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Partnership

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 HP4all project word cloud

Explore the words cloud of the HP4all project. It provides you a very rough idea of what is the project "HP4all" about.

chemistry    gt    sensitivity    resonance    separating    spins    polarized    goals    limitation    living    interesting    sciences    hp    formulations    molecular    series    physically    stored    techniques    enhancements    drug    hyperpolarization    protocols    detection    modern    animals    source    limits    chemical    time    keeps    transported    samples    hospitals    distances    analytical    lifetimes    notable    pioneered    provides    broadly    discovery    despite    substrate    tools    mri    powerful    revolutionizing    highest    reports    thereby    innovative    days    sophisticated    preparing    experiments    laboratories    dissolution    dynamic    below    magnetic    leap    metabolomics    boosting    instrumentation    leverage    diagnostics    breakthrough    microscopic    respect    industry    mr    efforts    nmr    suffer    imaging    versatile    demonstrated    solution    applicable    model    yield    combination    nuclear    proof    forefront    polarization    clinics    fold    generate    methodology    persistent    dnp    medical    extensively    metabolic    considerable    tool    aligned    centers   

Project "HP4all" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
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email: n.a.
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 Coordinator Country France [FR]
 Project website http://hmrlab.eu
 Total cost 1˙995˙000 €
 EC max contribution 1˙995˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 1˙995˙000.00

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 Project objective

Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry. Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. Hyperpolarization (HP) in principle provides a solution to this limitation. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR. By physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated. These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation. This project will yield to a broadly applicable method revolutionizing analytical chemistry, drug discovery and medical diagnostics, and thereby will provide a powerful tool to solve challenges at the forefront of molecular and chemical sciences today.

 Publications

year authors and title journal last update
List of publications.
2019 Alexey S. Kiryutin, Bogdan A. Rodin, Alexandra V. Yurkovskaya, Konstantin L. Ivanov, Dennis Kurzbach, Sami Jannin, David Guarin, Daniel Abergel, Geoffrey Bodenhausen
Transport of hyperpolarized samples in dissolution-DNP experiments
published pages: 13696-13705, ISSN: 1463-9076, DOI: 10.1039/c9cp02600b
Physical Chemistry Chemical Physics 21/25 2019-08-30
2019 Sami Jannin, Jean-Nicolas Dumez, Patrick Giraudeau, Dennis Kurzbach
Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts
published pages: 41-50, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.06.001
Journal of Magnetic Resonance 305 2019-08-30
2017 Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, Aurélien Bornet, Arthur C. Pinon, Gabriele Stevanato, Benno Meier, Geoffrey Bodenhausen, Sami Jannin, Malcolm H. Levitt
Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups
published pages: 3549-3555, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.7b01512
The Journal of Physical Chemistry Letters 8/15 2019-06-13
2017 Wolfram R. Grüning, Harald Bieringer, Martin Schwarzwälder, David Gajan, Aurélien Bornet, Basile Vuichoud, Jonas Milani, David Baudouin, Laurent Veyre, Anne Lesage, Sami Jannin, Geoffrey Bodenhausen, Chloé Thieuleux, Christophe Copéret
Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures
published pages: e1600122, ISSN: 0018-019X, DOI: 10.1002/hlca.201600122
Helvetica Chimica Acta 100/1 2019-06-13
2018 X. Ji, T.V. Can, F. Mentink-Vigier, A. Bornet, J. Milani, B. Vuichoud, M.A. Caporini, R.G. Griffin, S. Jannin, M. Goldman, G. Bodenhausen
Overhauser effects in non-conducting solids at 1.2 K
published pages: 138-142, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.11.017
Journal of Magnetic Resonance 286 2019-06-13
2017 Xiao Ji, Aurélien Bornet, Basile Vuichoud, Jonas Milani, David Gajan, Aaron J. Rossini, Lyndon Emsley, Geoffrey Bodenhausen, Sami Jannin
Transportable hyperpolarized metabolites
published pages: 13975, ISSN: 2041-1723, DOI: 10.1038/ncomms13975
Nature Communications 8 2019-06-13
2017 Daniel L. Silverio, Henri A. van Kalkeren, Ta-Chung Ong, Mathieu Baudin, Maxim Yulikov, Laurent Veyre, Pierrick Berruyer, Sachin Chaudhari, David Gajan, David Baudouin, Matthieu Cavaillès, Basile Vuichoud, Aurélien Bornet, Gunnar Jeschke, Geoffrey Bodenhausen, Anne Lesage, Lyndon Emsley, Sami Jannin, Chloé Thieuleux, Christophe Copéret
Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls
published pages: e1700101, ISSN: 0018-019X, DOI: 10.1002/hlca.201700101
Helvetica Chimica Acta 100/6 2019-06-13
2018 Mathieu Baudin, Basile Vuichoud, Aurélien Bornet, Geoffrey Bodenhausen, Sami Jannin
A cryogen-consumption-free system for dynamic nuclear polarization at 9.4 T
published pages: 115-121, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.07.001
Journal of Magnetic Resonance 294 2019-06-13
2018 Stuart J. Elliott, Benno Meier, Basile Vuichoud, Gabriele Stevanato, Lynda J. Brown, Javier Alonso-Valdesueiro, Lyndon Emsley, Sami Jannin, Malcolm H. Levitt
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
published pages: 9755-9759, ISSN: 1463-9076, DOI: 10.1039/c8cp00253c
Physical Chemistry Chemical Physics 20/15 2019-06-13
2018 Kirill V. Kovtunov, Ekaterina V. Pokochueva, Oleg G. Salnikov, Samuel F. Cousin, Dennis Kurzbach, Basile Vuichoud, Sami Jannin, Eduard Y. Chekmenev, Boyd M. Goodson, Danila A. Barskiy, Igor V. Koptyug
Hyperpolarized NMR Spectroscopy: d -DNP, PHIP, and SABRE Techniques
published pages: , ISSN: 1861-4728, DOI: 10.1002/asia.201800551
Chemistry - An Asian Journal 2019-06-13
2018 Bertrand Plainchont, Pierrick Berruyer, Jean-Nicolas Dumez, Sami Jannin, Patrick Giraudeau
Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry
published pages: 3639-3650, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b05236
Analytical Chemistry 90/6 2019-06-13
2017 Jonas Milani, Basile Vuichoud, Aurélien Bornet, Roberto Melzi, Sami Jannin, Geoffrey Bodenhausen
Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization
published pages: 15109, ISSN: 0034-6748, DOI: 10.1063/1.4973777
Review of Scientific Instruments 88/1 2019-06-13

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