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HP4all SIGNED

Persistent and Transportable Hyperpolarization for Magnetic Resonance

Total Cost €

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EC-Contrib. €

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Partnership

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 HP4all project word cloud

Explore the words cloud of the HP4all project. It provides you a very rough idea of what is the project "HP4all" about.

applicable    aligned    formulations    resonance    model    hyperpolarization    detection    diagnostics    dynamic    demonstrated    chemistry    highest    tools    gt    considerable    sciences    source    dnp    stored    time    enhancements    separating    hp    metabolomics    broadly    solution    extensively    revolutionizing    keeps    protocols    industry    substrate    below    thereby    methodology    leap    nuclear    spins    transported    respect    interesting    polarized    physically    imaging    molecular    nmr    limits    clinics    discovery    instrumentation    techniques    lifetimes    series    efforts    reports    versatile    medical    samples    laboratories    sensitivity    breakthrough    centers    dissolution    sophisticated    yield    tool    living    provides    proof    goals    innovative    fold    analytical    modern    pioneered    mr    polarization    forefront    chemical    persistent    days    mri    boosting    combination    metabolic    generate    experiments    preparing    distances    despite    drug    suffer    limitation    microscopic    animals    hospitals    powerful    leverage    magnetic    notable   

Project "HP4all" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
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surname: n.a.
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 Coordinator Country France [FR]
 Project website http://hmrlab.eu
 Total cost 1˙995˙000 €
 EC max contribution 1˙995˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 1˙995˙000.00

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 Project objective

Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry. Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. Hyperpolarization (HP) in principle provides a solution to this limitation. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR. By physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated. These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation. This project will yield to a broadly applicable method revolutionizing analytical chemistry, drug discovery and medical diagnostics, and thereby will provide a powerful tool to solve challenges at the forefront of molecular and chemical sciences today.

 Publications

year authors and title journal last update
List of publications.
2019 Alexey S. Kiryutin, Bogdan A. Rodin, Alexandra V. Yurkovskaya, Konstantin L. Ivanov, Dennis Kurzbach, Sami Jannin, David Guarin, Daniel Abergel, Geoffrey Bodenhausen
Transport of hyperpolarized samples in dissolution-DNP experiments
published pages: 13696-13705, ISSN: 1463-9076, DOI: 10.1039/c9cp02600b
Physical Chemistry Chemical Physics 21/25 2019-08-30
2019 Sami Jannin, Jean-Nicolas Dumez, Patrick Giraudeau, Dennis Kurzbach
Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts
published pages: 41-50, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.06.001
Journal of Magnetic Resonance 305 2019-08-30
2017 Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, Aurélien Bornet, Arthur C. Pinon, Gabriele Stevanato, Benno Meier, Geoffrey Bodenhausen, Sami Jannin, Malcolm H. Levitt
Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups
published pages: 3549-3555, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.7b01512
The Journal of Physical Chemistry Letters 8/15 2019-06-13
2017 Wolfram R. Grüning, Harald Bieringer, Martin Schwarzwälder, David Gajan, Aurélien Bornet, Basile Vuichoud, Jonas Milani, David Baudouin, Laurent Veyre, Anne Lesage, Sami Jannin, Geoffrey Bodenhausen, Chloé Thieuleux, Christophe Copéret
Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures
published pages: e1600122, ISSN: 0018-019X, DOI: 10.1002/hlca.201600122
Helvetica Chimica Acta 100/1 2019-06-13
2018 X. Ji, T.V. Can, F. Mentink-Vigier, A. Bornet, J. Milani, B. Vuichoud, M.A. Caporini, R.G. Griffin, S. Jannin, M. Goldman, G. Bodenhausen
Overhauser effects in non-conducting solids at 1.2 K
published pages: 138-142, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.11.017
Journal of Magnetic Resonance 286 2019-06-13
2017 Xiao Ji, Aurélien Bornet, Basile Vuichoud, Jonas Milani, David Gajan, Aaron J. Rossini, Lyndon Emsley, Geoffrey Bodenhausen, Sami Jannin
Transportable hyperpolarized metabolites
published pages: 13975, ISSN: 2041-1723, DOI: 10.1038/ncomms13975
Nature Communications 8 2019-06-13
2017 Daniel L. Silverio, Henri A. van Kalkeren, Ta-Chung Ong, Mathieu Baudin, Maxim Yulikov, Laurent Veyre, Pierrick Berruyer, Sachin Chaudhari, David Gajan, David Baudouin, Matthieu Cavaillès, Basile Vuichoud, Aurélien Bornet, Gunnar Jeschke, Geoffrey Bodenhausen, Anne Lesage, Lyndon Emsley, Sami Jannin, Chloé Thieuleux, Christophe Copéret
Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls
published pages: e1700101, ISSN: 0018-019X, DOI: 10.1002/hlca.201700101
Helvetica Chimica Acta 100/6 2019-06-13
2018 Mathieu Baudin, Basile Vuichoud, Aurélien Bornet, Geoffrey Bodenhausen, Sami Jannin
A cryogen-consumption-free system for dynamic nuclear polarization at 9.4 T
published pages: 115-121, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.07.001
Journal of Magnetic Resonance 294 2019-06-13
2018 Stuart J. Elliott, Benno Meier, Basile Vuichoud, Gabriele Stevanato, Lynda J. Brown, Javier Alonso-Valdesueiro, Lyndon Emsley, Sami Jannin, Malcolm H. Levitt
Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
published pages: 9755-9759, ISSN: 1463-9076, DOI: 10.1039/c8cp00253c
Physical Chemistry Chemical Physics 20/15 2019-06-13
2018 Kirill V. Kovtunov, Ekaterina V. Pokochueva, Oleg G. Salnikov, Samuel F. Cousin, Dennis Kurzbach, Basile Vuichoud, Sami Jannin, Eduard Y. Chekmenev, Boyd M. Goodson, Danila A. Barskiy, Igor V. Koptyug
Hyperpolarized NMR Spectroscopy: d -DNP, PHIP, and SABRE Techniques
published pages: , ISSN: 1861-4728, DOI: 10.1002/asia.201800551
Chemistry - An Asian Journal 2019-06-13
2018 Bertrand Plainchont, Pierrick Berruyer, Jean-Nicolas Dumez, Sami Jannin, Patrick Giraudeau
Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry
published pages: 3639-3650, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b05236
Analytical Chemistry 90/6 2019-06-13
2017 Jonas Milani, Basile Vuichoud, Aurélien Bornet, Roberto Melzi, Sami Jannin, Geoffrey Bodenhausen
Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization
published pages: 15109, ISSN: 0034-6748, DOI: 10.1063/1.4973777
Review of Scientific Instruments 88/1 2019-06-13

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