Explore the words cloud of the iNAPS project. It provides you a very rough idea of what is the project "iNAPS" about.
The following table provides information about the project.
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
|Coordinator Country||Germany [DE]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
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|1||HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH||DE (NEUHERBERG)||coordinator||1˙500˙000.00|
Sleep is crucial to the brain’s remarkable regenerative and adaptive capabilities. Inadequate sleep is a pervasive problem that severely impairs brain function, productivity, and health. How the brain homeostatically senses sleep need and translates it into the intensified rebound sleep (RBS) that follows sleep deprivation (SD) still remains unclear. I aim to understand these mechanisms and to identify therapeutic targets that will promote consolidated, restorative sleep, enabling the development of superior sleep aids. Furthermore, this will shed light on the enigmatic yet fundamental question of the function of sleep. Astrocyte activation increases sleep, and astrocytes release adenosine (ado), a key messenger for sleep homeostasis. Thus, astrocytic-neuronal interactions likely decode sleep pressure into RBS via adenosinergic mechanisms. I discovered that cortical interneurons expressing neuronal nitric oxide synthase (nNOS) and neurokinin-1 receptor (NK1), which are selectively activated in RBS, show highly unusual excitatory responses to ado that are sensitive to sleep pressure. Furthermore, I found that knockout of a specific ado receptor in mice caused reduced numbers of cortical nNOS/NK1 neurons as well as a delayed RBS response. Based on these findings, I hypothesise that cortical nNOS/NK1 neurons play a key role in sleep homeostasis. My group now aims to 1) identify the comprehensive sleep homeostasis machinery, by building transcriptomic profiles of neurons activated during and after SD in mice using phosphorylated ribosome profiling, 2) verify the function of these newly identified neurons in sleep homeostasis by activity imaging and chemogenetic manipulation in vivo, and 3) investigate the functional role of astrocytes in the sleep homeostasis network. These studies will form the foundation for a new generation of sleep aids that are urgently needed to safeguard the productivity and health of our society.
|year||authors and title||journal||last update|
RhÃ®annan H Williams, Jacqueline Vazquez-DeRose, Alexia M Thomas, Juliette Piquet, Bruno Cauli, Thomas S Kilduff
Cortical nNOS/NK1 Receptor Neurons are Regulated by Cholinergic Projections From the Basal Forebrain
published pages: 1959-1979, ISSN: 1047-3211, DOI: 10.1093/cercor/bhx102
|Cerebral Cortex 28/6||2019-12-16|
RhÃ®annan H. Williams, Tomomi Tsunematsu, Alexia M. Thomas, Kelsie Bogyo, Akihiro Yamanaka, Thomas S. Kilduff
Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy
published pages: 9435-9452, ISSN: 0270-6474, DOI: 10.1523/jneurosci.0311-19.2019
|The Journal of Neuroscience 39/47||2019-12-16|
RhÃ®annan H Williams, Sarah W Black, Alexia M Thomas, Juliette Piquet, Bruno Cauli, Thomas S Kilduff
Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis
published pages: 1090-1108, ISSN: 1047-3211, DOI: 10.1093/cercor/bhy015
|Cerebral Cortex 29/3||2019-12-16|
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