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SynchroSelf TERMINATED

Harnessing reversibility of peptide Self-Assembly processes to Synchronise Extracellular Matrix substitutes with cellular driven tissue reconstruction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynchroSelf project word cloud

Explore the words cloud of the SynchroSelf project. It provides you a very rough idea of what is the project "SynchroSelf" about.

self    people    controls    chemistry    worldwide    geometrical    interdisciplinary    diverse    sciences    therapies    efforts    smart    experimental    assembly    perhaps    health    care    class    aging    substitute    peptide    material    ecm    restore    components    function    dynamic    time    irreversible    copycat    central    matrix    native    millions    endeavour    mainly    organs    burdens    turnover    materials    area    placing    temporarily    life    spatial    advantage    quality    huge    biochemistry    vitro    interactions    community    functional    matched    generate    healing    ischemia    scientific    trauma    unprecedented    synchronise    nature    create    relatives    tissues    extracellular    start    systematically    reversible    bottlenecks    solutions    cancer    synchroself    designed    supramolecular    scientists    watches    biology    wound    engineered    complexity    man    made    consistently    spectrum    regenerative    pave    medicine    fundamental    diseases    tissue    patient    human    biomaterials    cell    substitutes    attempt    degenerative   

Project "SynchroSelf" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Irreversible tissue loss is a common feature in a large spectrum of health conditions (e.g. aging, trauma, cancer, degenerative diseases, ischemia, etc), placing huge burdens in patient relatives and health care systems. Therapies aiming to restore tissue function will have a great impact in the health and quality of life of millions of people worldwide.

Regenerative medicine is an interdisciplinary endeavour to create functional tissues and organs, where cell biology, biochemistry, chemistry and material sciences are central components to address human tissues complexity. The approach comprises the use of biomaterials that temporarily substitute the extracellular matrix (ECM). However, current engineered biomaterials have not fully matched the diverse functionality of native tissues. Thus, fundamental research in biomaterials for regenerative medicine has great potential to provide smart solutions to current bottlenecks in this scientific area.

In this project, biomaterials based on peptide self-assembly will be designed to take advantage of reversible supramolecular interactions, in order to create self-healing ECM substitutes. The dynamic nature of these materials will be addressed systematically in an attempt to copycat ECM turnover. So far, efforts from the materials scientific community have been mainly focused on controlling spatial and geometrical features. Perhaps it is time to start addressing consistently time variable controls in biomaterials design, and to pave the way to fully synchronise the biology and man-made materials’ “watches”. We expect that SynchroSelf will generate a new class of dynamic biomaterials that will enable scientists to study wound healing processes in vitro with unprecedented level of complexity and experimental control.

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The information about "SYNCHROSELF" are provided by the European Opendata Portal: CORDIS opendata.

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