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SynchroSelf TERMINATED

Harnessing reversibility of peptide Self-Assembly processes to Synchronise Extracellular Matrix substitutes with cellular driven tissue reconstruction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynchroSelf project word cloud

Explore the words cloud of the SynchroSelf project. It provides you a very rough idea of what is the project "SynchroSelf" about.

care    perhaps    biology    scientific    advantage    experimental    biochemistry    burdens    bottlenecks    endeavour    spectrum    sciences    synchroself    tissue    huge    diseases    degenerative    consistently    attempt    engineered    central    placing    patient    mainly    controls    pave    components    reversible    substitute    turnover    functional    community    man    therapies    material    area    function    restore    biomaterials    create    materials    temporarily    generate    geometrical    assembly    organs    systematically    dynamic    wound    millions    aging    extracellular    healing    ecm    smart    human    trauma    fundamental    irreversible    spatial    quality    interactions    vitro    chemistry    start    self    worldwide    medicine    health    tissues    efforts    native    matrix    regenerative    nature    interdisciplinary    scientists    diverse    designed    complexity    solutions    cancer    watches    cell    ischemia    synchronise    matched    made    unprecedented    peptide    supramolecular    time    copycat    class    substitutes    people    relatives    life   

Project "SynchroSelf" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Irreversible tissue loss is a common feature in a large spectrum of health conditions (e.g. aging, trauma, cancer, degenerative diseases, ischemia, etc), placing huge burdens in patient relatives and health care systems. Therapies aiming to restore tissue function will have a great impact in the health and quality of life of millions of people worldwide.

Regenerative medicine is an interdisciplinary endeavour to create functional tissues and organs, where cell biology, biochemistry, chemistry and material sciences are central components to address human tissues complexity. The approach comprises the use of biomaterials that temporarily substitute the extracellular matrix (ECM). However, current engineered biomaterials have not fully matched the diverse functionality of native tissues. Thus, fundamental research in biomaterials for regenerative medicine has great potential to provide smart solutions to current bottlenecks in this scientific area.

In this project, biomaterials based on peptide self-assembly will be designed to take advantage of reversible supramolecular interactions, in order to create self-healing ECM substitutes. The dynamic nature of these materials will be addressed systematically in an attempt to copycat ECM turnover. So far, efforts from the materials scientific community have been mainly focused on controlling spatial and geometrical features. Perhaps it is time to start addressing consistently time variable controls in biomaterials design, and to pave the way to fully synchronise the biology and man-made materials’ “watches”. We expect that SynchroSelf will generate a new class of dynamic biomaterials that will enable scientists to study wound healing processes in vitro with unprecedented level of complexity and experimental control.

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The information about "SYNCHROSELF" are provided by the European Opendata Portal: CORDIS opendata.

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