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SynchroSelf TERMINATED

Harnessing reversibility of peptide Self-Assembly processes to Synchronise Extracellular Matrix substitutes with cellular driven tissue reconstruction

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SynchroSelf project word cloud

Explore the words cloud of the SynchroSelf project. It provides you a very rough idea of what is the project "SynchroSelf" about.

designed    quality    fundamental    placing    synchronise    diseases    attempt    components    diverse    life    experimental    made    vitro    medicine    substitute    function    central    human    biomaterials    patient    consistently    ischemia    create    peptide    assembly    unprecedented    matrix    aging    materials    biology    community    pave    self    efforts    watches    cancer    extracellular    relatives    irreversible    systematically    interdisciplinary    complexity    nature    huge    trauma    area    organs    dynamic    sciences    burdens    perhaps    tissues    worldwide    reversible    mainly    cell    spectrum    spatial    biochemistry    interactions    time    generate    bottlenecks    restore    scientific    material    care    degenerative    therapies    endeavour    class    tissue    copycat    synchroself    geometrical    scientists    healing    smart    ecm    people    millions    regenerative    advantage    functional    supramolecular    temporarily    health    native    wound    chemistry    controls    turnover    start    matched    engineered    substitutes    man    solutions   

Project "SynchroSelf" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Irreversible tissue loss is a common feature in a large spectrum of health conditions (e.g. aging, trauma, cancer, degenerative diseases, ischemia, etc), placing huge burdens in patient relatives and health care systems. Therapies aiming to restore tissue function will have a great impact in the health and quality of life of millions of people worldwide.

Regenerative medicine is an interdisciplinary endeavour to create functional tissues and organs, where cell biology, biochemistry, chemistry and material sciences are central components to address human tissues complexity. The approach comprises the use of biomaterials that temporarily substitute the extracellular matrix (ECM). However, current engineered biomaterials have not fully matched the diverse functionality of native tissues. Thus, fundamental research in biomaterials for regenerative medicine has great potential to provide smart solutions to current bottlenecks in this scientific area.

In this project, biomaterials based on peptide self-assembly will be designed to take advantage of reversible supramolecular interactions, in order to create self-healing ECM substitutes. The dynamic nature of these materials will be addressed systematically in an attempt to copycat ECM turnover. So far, efforts from the materials scientific community have been mainly focused on controlling spatial and geometrical features. Perhaps it is time to start addressing consistently time variable controls in biomaterials design, and to pave the way to fully synchronise the biology and man-made materials’ “watches”. We expect that SynchroSelf will generate a new class of dynamic biomaterials that will enable scientists to study wound healing processes in vitro with unprecedented level of complexity and experimental control.

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The information about "SYNCHROSELF" are provided by the European Opendata Portal: CORDIS opendata.

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