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Harnessing reversibility of peptide Self-Assembly processes to Synchronise Extracellular Matrix substitutes with cellular driven tissue reconstruction

Total Cost €


EC-Contrib. €






 SynchroSelf project word cloud

Explore the words cloud of the SynchroSelf project. It provides you a very rough idea of what is the project "SynchroSelf" about.

worldwide    function    complexity    reversible    self    human    peptide    designed    watches    start    regenerative    wound    placing    aging    scientific    ecm    vitro    efforts    irreversible    biomaterials    ischemia    advantage    biochemistry    supramolecular    millions    generate    endeavour    spatial    time    made    functional    central    geometrical    matrix    life    native    components    fundamental    temporarily    scientists    attempt    systematically    matched    class    synchronise    area    solutions    consistently    create    man    substitutes    cancer    patient    people    dynamic    synchroself    interactions    degenerative    perhaps    substitute    therapies    sciences    relatives    health    spectrum    copycat    turnover    tissues    controls    organs    pave    cell    restore    mainly    diseases    quality    bottlenecks    burdens    healing    unprecedented    experimental    materials    biology    huge    medicine    material    interdisciplinary    smart    community    chemistry    engineered    trauma    assembly    tissue    care    diverse    extracellular    nature   

Project "SynchroSelf" data sheet

The following table provides information about the project.


Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  0000-00-00


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00


 Project objective

Irreversible tissue loss is a common feature in a large spectrum of health conditions (e.g. aging, trauma, cancer, degenerative diseases, ischemia, etc), placing huge burdens in patient relatives and health care systems. Therapies aiming to restore tissue function will have a great impact in the health and quality of life of millions of people worldwide.

Regenerative medicine is an interdisciplinary endeavour to create functional tissues and organs, where cell biology, biochemistry, chemistry and material sciences are central components to address human tissues complexity. The approach comprises the use of biomaterials that temporarily substitute the extracellular matrix (ECM). However, current engineered biomaterials have not fully matched the diverse functionality of native tissues. Thus, fundamental research in biomaterials for regenerative medicine has great potential to provide smart solutions to current bottlenecks in this scientific area.

In this project, biomaterials based on peptide self-assembly will be designed to take advantage of reversible supramolecular interactions, in order to create self-healing ECM substitutes. The dynamic nature of these materials will be addressed systematically in an attempt to copycat ECM turnover. So far, efforts from the materials scientific community have been mainly focused on controlling spatial and geometrical features. Perhaps it is time to start addressing consistently time variable controls in biomaterials design, and to pave the way to fully synchronise the biology and man-made materials’ “watches”. We expect that SynchroSelf will generate a new class of dynamic biomaterials that will enable scientists to study wound healing processes in vitro with unprecedented level of complexity and experimental control.

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The information about "SYNCHROSELF" are provided by the European Opendata Portal: CORDIS opendata.

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