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MecMy SIGNED

Mechanisms of Myelination – Elucidating the Diversity of Oligodendroglial Precursors and their Local Axon-Glia Interactions

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MecMy project word cloud

Explore the words cloud of the MecMy project. It provides you a very rough idea of what is the project "MecMy" about.

function    mechanistic    oligodendroglia    ensures    live    precursors    myriads    local    lifelong    interaction    model    carry    organism    transmission    axon    myelination    oligodendroglial    employ    organ    goals    intrinsic    fundamentally    structure    ideally    mediators    communication    principles    underlying    interactions    time    survival    fails    myelinated    tract    fast    glial    insights    myelin    causal    regulating    genetic    nervous    learning    disease    diversity    lastly    unclear    abundant    dynamics    mechanisms    inefficient    suited    signature    subcellular    damage    generate    form    reveal    normal    diverse    surrounded    precursor    clonal    individual    imaging    global    first    cells    strategies    glia    molecular    repair    specialized    manipulation    cellular    specification    regulatory    vivo    heterogeneity    memory    signal    device    extrinsic    insulating    functional    cell    precise    animal    zebrafish    elucidate    neurons    population    axons    differentiation   

Project "MecMy" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙485˙000 €
 EC max contribution 1˙485˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙485˙000.00

Map

 Project objective

Nervous system function requires precise communication between myriads of neurons and glia to generate and maintain a functional organ. Most axons are eventually surrounded with myelin, an insulating structure produced by specialized oligodendroglia. This cellular interaction enables fast signal transmission, ensures long-term axon survival, and is involved in regulating learning and memory formation. The formation of new myelin during lifelong development and after myelin damage requires differentiation of oligodendroglial precursors. Although these cells are an abundant population, myelin repair is often inefficient and eventually fails. It is known that oligodendroglial precursors have diverse properties, but whether this diversity is at any level a regulatory factor for normal myelination, or causal to failure of myelin repair is unclear. Here, I will elucidate the diversity of oligodendroglial precursors by carrying out the first global analysis of their population dynamics in the whole animal from specification to myelination. I will investigate how differentiation properties change over time, reveal whether this is due to intrinsic or extrinsic factors, and identify the underlying molecular mechanisms. To achieve these goals I will use zebrafish, an ideally suited model organism for in vivo live cell imaging and genetic manipulation. I will carry out a clonal analysis of oligodendroglial precursor population dynamics during myelinated tract formation and after myelin damage. I will analyse the molecular signature of cells with different properties to identify crucial mediators. Lastly, I will investigate whether individual cells can show diversity at the subcellular mechanistic level of local axon-glial interactions. My work will provide fundamentally new insights into the principles of the heterogeneity of oligodendroglial precursors and may help to device new strategies of how to employ these cells to form new myelin in development and disease.

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The information about "MECMY" are provided by the European Opendata Portal: CORDIS opendata.

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