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MecMy SIGNED

Mechanisms of Myelination – Elucidating the Diversity of Oligodendroglial Precursors and their Local Axon-Glia Interactions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MecMy project word cloud

Explore the words cloud of the MecMy project. It provides you a very rough idea of what is the project "MecMy" about.

time    damage    cell    manipulation    subcellular    precursor    molecular    learning    functional    lifelong    cellular    signal    differentiation    lastly    vivo    employ    carry    individual    signature    model    disease    goals    mediators    oligodendroglial    cells    regulating    underlying    extrinsic    regulatory    genetic    animal    communication    axon    intrinsic    reveal    imaging    transmission    specification    myelin    ensures    diversity    tract    neurons    function    oligodendroglia    causal    memory    elucidate    strategies    myelination    dynamics    fast    nervous    clonal    suited    survival    glial    device    interactions    fundamentally    fails    mechanisms    abundant    interaction    generate    glia    precise    repair    diverse    zebrafish    ideally    principles    population    precursors    first    live    heterogeneity    structure    insights    organism    global    insulating    normal    myelinated    surrounded    organ    mechanistic    myriads    specialized    unclear    axons    inefficient    form    local   

Project "MecMy" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙485˙000 €
 EC max contribution 1˙485˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙485˙000.00

Map

 Project objective

Nervous system function requires precise communication between myriads of neurons and glia to generate and maintain a functional organ. Most axons are eventually surrounded with myelin, an insulating structure produced by specialized oligodendroglia. This cellular interaction enables fast signal transmission, ensures long-term axon survival, and is involved in regulating learning and memory formation. The formation of new myelin during lifelong development and after myelin damage requires differentiation of oligodendroglial precursors. Although these cells are an abundant population, myelin repair is often inefficient and eventually fails. It is known that oligodendroglial precursors have diverse properties, but whether this diversity is at any level a regulatory factor for normal myelination, or causal to failure of myelin repair is unclear. Here, I will elucidate the diversity of oligodendroglial precursors by carrying out the first global analysis of their population dynamics in the whole animal from specification to myelination. I will investigate how differentiation properties change over time, reveal whether this is due to intrinsic or extrinsic factors, and identify the underlying molecular mechanisms. To achieve these goals I will use zebrafish, an ideally suited model organism for in vivo live cell imaging and genetic manipulation. I will carry out a clonal analysis of oligodendroglial precursor population dynamics during myelinated tract formation and after myelin damage. I will analyse the molecular signature of cells with different properties to identify crucial mediators. Lastly, I will investigate whether individual cells can show diversity at the subcellular mechanistic level of local axon-glial interactions. My work will provide fundamentally new insights into the principles of the heterogeneity of oligodendroglial precursors and may help to device new strategies of how to employ these cells to form new myelin in development and disease.

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The information about "MECMY" are provided by the European Opendata Portal: CORDIS opendata.

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