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MecMy SIGNED

Mechanisms of Myelination – Elucidating the Diversity of Oligodendroglial Precursors and their Local Axon-Glia Interactions

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MecMy project word cloud

Explore the words cloud of the MecMy project. It provides you a very rough idea of what is the project "MecMy" about.

function    global    memory    zebrafish    myelinated    model    structure    precursor    precursors    live    causal    transmission    organism    extrinsic    dynamics    manipulation    tract    functional    glia    myelination    vivo    repair    signature    form    employ    damage    specification    insights    inefficient    generate    survival    interaction    cellular    ideally    goals    lastly    normal    lifelong    fundamentally    surrounded    genetic    fails    ensures    suited    signal    differentiation    heterogeneity    cell    disease    nervous    molecular    regulating    neurons    myriads    unclear    specialized    axon    imaging    underlying    oligodendroglia    regulatory    reveal    learning    principles    communication    glial    mediators    local    precise    abundant    fast    device    clonal    mechanistic    axons    population    diversity    myelin    carry    animal    strategies    organ    oligodendroglial    insulating    diverse    intrinsic    elucidate    time    first    mechanisms    individual    interactions    subcellular    cells   

Project "MecMy" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙485˙000 €
 EC max contribution 1˙485˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙485˙000.00

Map

 Project objective

Nervous system function requires precise communication between myriads of neurons and glia to generate and maintain a functional organ. Most axons are eventually surrounded with myelin, an insulating structure produced by specialized oligodendroglia. This cellular interaction enables fast signal transmission, ensures long-term axon survival, and is involved in regulating learning and memory formation. The formation of new myelin during lifelong development and after myelin damage requires differentiation of oligodendroglial precursors. Although these cells are an abundant population, myelin repair is often inefficient and eventually fails. It is known that oligodendroglial precursors have diverse properties, but whether this diversity is at any level a regulatory factor for normal myelination, or causal to failure of myelin repair is unclear. Here, I will elucidate the diversity of oligodendroglial precursors by carrying out the first global analysis of their population dynamics in the whole animal from specification to myelination. I will investigate how differentiation properties change over time, reveal whether this is due to intrinsic or extrinsic factors, and identify the underlying molecular mechanisms. To achieve these goals I will use zebrafish, an ideally suited model organism for in vivo live cell imaging and genetic manipulation. I will carry out a clonal analysis of oligodendroglial precursor population dynamics during myelinated tract formation and after myelin damage. I will analyse the molecular signature of cells with different properties to identify crucial mediators. Lastly, I will investigate whether individual cells can show diversity at the subcellular mechanistic level of local axon-glial interactions. My work will provide fundamentally new insights into the principles of the heterogeneity of oligodendroglial precursors and may help to device new strategies of how to employ these cells to form new myelin in development and disease.

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The information about "MECMY" are provided by the European Opendata Portal: CORDIS opendata.

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