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Waterscales SIGNED

Mathematical and computational foundations for modeling cerebral fluid flow.

Total Cost €

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EC-Contrib. €

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Project "Waterscales" data sheet

The following table provides information about the project.

Coordinator
SIMULA RESEARCH LABORATORY AS 

Organization address
address: MARTIN LINGES VEI 17
city: FORNEBU
postcode: 1364
website: www.simula.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SIMULA RESEARCH LABORATORY AS NO (FORNEBU) coordinator 1˙500˙000.00

Map

 Project objective

Your brain has its own waterscape: whether you are reading or sleeping, fluid flows through the brain tissue and clears waste in the process. These physiological processes are crucial for the well-being of the brain. In spite of their importance we understand them but little. Mathematics and numerics could play a crucial role in gaining new insight. Indeed, medical doctors express an urgent need for multiscale modeling of water transport through the brain, to overcome limitations in traditional techniques. Surprisingly little attention has been paid to the numerics of the brain's waterscape however, and fundamental knowledge is missing.

In response, the Waterscales ambition is to establish the mathematical and computational foundations for predictively modeling fluid flow and solute transport through the brain across scales -- from the cellular to the organ level. The project aims to bridge multiscale fluid mechanics and cellular electrophysiology to pioneer new families of mathematical models that couple macroscale, mesoscale and microscale flow with glial cell dynamics. For these models, we will design numerical discretizations that preserve key properties and that allow for whole organ simulations. To evaluate predictability, we will develop a new computational platform for model adaptivity and calibration. The project is multidisciplinary combining mathematics, mechanics, scientific computing, and physiology.

If successful, this project enables the first in silico studies of the brain's waterscape across scales. The new models would open up a new research field within computational neuroscience with ample opportunities for further mathematical and more applied study. The processes at hand are associated with neurodegenerative diseases e.g. dementia and with brain swelling caused by e.g. stroke. The Waterscales project will provide the field with a sorely needed, new avenue of investigation to understand these conditions, with tremendous long-term impact.

 Publications

year authors and title journal last update
List of publications.
2019 Xiaoran Lai, Oliver M. Geier, Thomas Fleischer, Øystein Garred, Elin Borgen, Simon W. Funke, Surendra Kumar, Marie E. Rognes, Therese Seierstad, Anne-Lise Børresen-Dale, Vessela N. Kristensen, Olav Engebraaten, Alvaro Köhn-Luque, Arnoldo Frigessi
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
published pages: 4293-4304, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-1804
Cancer Research 79/16 2019-11-28
2019 Geir Halnes, Klas H. Pettersen, Leiv Øyehaug, Marie E. Rognes, Gaute T. Einevoll
Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow
published pages: 363-391, ISSN: , DOI:
Computational Glioscience 1 2019-11-28

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The information about "WATERSCALES" are provided by the European Opendata Portal: CORDIS opendata.

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