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Targeting of host proteins by unrelated pathogen effectors and their surveillance by allelic immune receptors

Total Cost €


EC-Contrib. €






 TOPPER project word cloud

Explore the words cloud of the TOPPER project. It provides you a very rough idea of what is the project "TOPPER" about.

detected    planck    rust    sr33    virulence    mildew    interception    arms    bgh    cognate    pgt    nod    secrete    tritici    mla    pathogenic    wish    resistance    proteins    oligomerization    specialis    fungi    graminis    microorganisms    genes    battle    proliferation    orthologs    scientific    puccinia    breeding    signalling    conserved    confer    recognition    topper    receptor    agriculture    monitor    variants    race    community    sr50    revealed    fungus    manipulated    defence    evolutionary    hypothesize    basal    effector    unexpectedly    plants    diversification    independently    host    disease    pathogen    appropriate    allelic    mechanism    tested    nlr    mediated    binding    wheat    deployment    additionally    cereals    direct    components    effectors    max    reintegrate    protein    barley    diversified    isolate    blumeria    nucleotide    converge    co    functional    ancestors    bind    locus    encoded    encode    belong    rye    clarify    phyla    plant    pathogens    stem    germany    2blades    powdery    hordei    perform    remarkable    unrelated    prevents    forma    consisting    sequence    cells    modifications    cologne   

Project "TOPPER" data sheet

The following table provides information about the project.


Organization address
city: Munich
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Pathogens secrete effectors into host cells to promote virulence and often establish disease by interception of basal defence components. One widespread mechanism of disease resistance in plants requires nucleotide-binding oligomerization (NOD)-like receptor (NLR) genes. Recognition of an effector by a cognate NLR prevents pathogen proliferation. A co-evolutionary arms race between the host barley and the pathogenic powdery mildew fungus Blumeria graminis forma specialis hordei (Bgh) has driven the functional diversification of allelic NLR variants encoded at the MLA disease resistance locus (for Mildew locus A). Recent work revealed that Bgh effectors detected by allelic MLA receptor variants are unexpectedly sequence-unrelated and evolved independently from different ancestors. Additionally, the MLA orthologs in wheat and rye, Sr33 and Sr50, confer isolate-specific resistance to the stem rust pathogen Puccinia graminis forma specialis tritici (Pgt). This is remarkable because rust and mildew fungi belong to different phyla and cannot encode sequence-related effectors. MLA variants can therefore not have diversified to directly bind sequence-related effectors and thus monitor effector-mediated modifications of host targets conserved between different cereals. To reintegrate into the European scientific community, I wish to perform the “TOPPER” project at the Max-Planck Institute for Plant Breeding Research, Cologne, Germany. The “TOPPER” project will clarify whether the sequence-unrelated Bgh effectors target the same host protein or converge on a common signalling pathway/complex consisting of related or unrelated host proteins. I hypothesize that the host protein(s), manipulated by Bgh effectors, is/are also targeted by effectors of other plant-associated microorganisms, which will be tested here. The collaboration with the partner ‘2Blades’ will ensure direct deployment of results in agriculture to battle plant disease, where appropriate.


year authors and title journal last update
List of publications.
2019 Isabel M. L. Saur, Saskia Bauer, Xunli Lu, Paul Schulze-Lefert
A cell death assay in barley and wheat protoplasts for identification and validation of matching pathogen AVR effector and plant NLR immune receptors
published pages: , ISSN: 1746-4811, DOI: 10.1186/s13007-019-0502-0
Plant Methods 15/1 2020-04-15

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The information about "TOPPER" are provided by the European Opendata Portal: CORDIS opendata.

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