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IMGENE SIGNED

Improving Genome Editing Efficiency (IMGENE)

Total Cost €

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EC-Contrib. €

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Partnership

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Project "IMGENE" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://imgene.ku.dk/
 Total cost 2˙068˙409 €
 EC max contribution 2˙068˙409 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 580˙163.00
2    ASTRAZENECA AB SE (SODERTAELJE) participant 263˙659.00
3    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 255˙374.00
4    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) participant 249˙216.00
5    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 249˙216.00
6    INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC PT (PORTO) participant 238˙356.00
7    USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE CZ (PRAHA 4) participant 232˙422.00
8    Genetic Alliance UK (LONDON) partner 0.00
9    Millipore Sigma US (Massachusetts) partner 0.00
10    Taconic GmbH DE (Cologne) partner 0.00

Map

 Project objective

CRISPR genome editing technology is considered to become the greatest technological improvement in biomedical research since the invention of the polymerase chain reaction 25 years ago and pharmaceutical companies as well as academic research are eager to apply it. However, the efficiency of introducing defined changes into the genome by CRISPR is still low, currently limiting its application in basic research, industry and gene therapy. IMGENE unites expert European research groups of academia and industry to address by innovative and complementary approaches the low efficiency of precise genome editing using CRISPR technology. To our best knowledge, IMGENE is the only concerted approach to tackle the important problem of low genome editing efficiency of CRISPR in a multidisciplinary, intersectorial manner. The IMGENE consortium consisting of 6 academic and 1 industrial beneficiary (AstraZeneca), 2 industrial partners (Taconic; MilliporeSigma), and the patient organization Genetic Alliance, aims to improve the genome editing efficiency of CRISPR by research training of 8 ESRs to unleash the full potential of this technology. Combining complementary knowledge on protein chemistry, molecular biology, cellular biology, viral vectors, transgenic mice, gene therapy, and bioinformatics present in the network, IMGENE will establish novel tools and protocols for improved CRISPR genome editing efficiency that will be of immediate benefit for health and life science research, the pharmaceutical industry, and the application of gene therapy. In addition, IMGENE addresses crucial ethical questions related to the application of genome editing technology in animals, plants, and humans, which have to be solved to gain acceptance by the society. By excellent research training of 8 ESRs on a scientifically and economically highly relevant topic and additional training in transferable skills, IMGENE will educate novel leaders with great career perspectives in industry and academia.

 Publications

year authors and title journal last update
List of publications.
2019 Xiaoyu Chen, Francesca Tasca, Qian Wang, Jin Liu, Josephine M Janssen, Marcella D Brescia, Milena Bellin, Karoly Szuhai, Josefin Kenrick, Richard L Frock, Manuel A F V Gonçalves
Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gkz1121
Nucleic Acids Research 2020-01-30

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The information about "IMGENE" are provided by the European Opendata Portal: CORDIS opendata.

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