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Super-resolution optical microscopy of nanosized pore dynamics in endothelial cells

Total Cost €


EC-Contrib. €






 DeLIVER project word cloud

Explore the words cloud of the DeLIVER project. It provides you a very rough idea of what is the project "DeLIVER" about.

excellent    little    complementary    deliver    creative    function    barrier    optical    tissues    interface    career    active    imaging    entrepreneurial    intersectoral    innovative    training    brain    fixed    nanoscopes    speed    esrs    combined    extremely    clinical    enhanced    liver    endothelial    sciences    newcomers    discoveries    physiology    human    trained    time    themselves    dead    slow    benefits    cross    metabolites    generation    blood    mobile    area    pollinated    prospects    academic    image    economic    transfer    vital    physical    clearance    resolution    navigate    biomedically    reconstruction    nanoscopy    kidneys    private    dynamics    artifacts    structures    analytical    physiological    pharmaceuticals    familiarize    arise    first    ec    cells    nanosized    eyes    scientific    maximising    biomedicine    name    super    reveal    physics    tools    enterprises    biomedical    train    newly    international    pores    instil    micro    manipulation    confidently    mind    skills    isolated    specialised    organs   

Project "DeLIVER" data sheet

The following table provides information about the project.


Organization address
postcode: 33615

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙728˙513 €
 EC max contribution 3˙728˙513 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BIELEFELD DE (BIELEFELD) coordinator 747˙649.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 263˙659.00
6    CHERRY BIOTECH FR (RENNES) participant 262˙875.00
7    ELVESYS FR (PARIS) participant 262˙875.00
8    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) participant 250˙560.00
9    LAVISION BIOTEC GMBH DE (BIELEFELD) participant 249˙216.00
10    ANZAC Health & Medical Research Foundation AU (CONCORD NSW) partner 0.00
11    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) partner 0.00
12    Norinnova Technology Transfer AS NO (Tromsø) partner 0.00
13    THE UNIVERSITY OF HONG KONG HK (Pokfulam) partner 0.00
14    United States Department of Health and Human Services US (Washington D.C.) partner 0.00


 Project objective

DeLIVER will train a new generation of ESRs in the development and application of newly developed high speed and high resolution imaging tools in biomedical research. ESRs will be cross-pollinated with concepts and skills in physics and biomedicine, in particular in super-resolution optical imaging (a.k.a. optical nanoscopy), analytical image reconstruction, and optical micro-manipulation methods. These skills are applied to reveal for the first time the function and dynamics of nanosized pores in endothelial cells (EC) that present the main barrier between the blood and vital organs for human physiology, such as the liver, brain, kidneys, and the eyes. Very little is known about the extremely important physiological function of these unique structures and their role in the transfer and/or clearance of metabolites and pharmaceuticals to vital organs. The current generation of optical nanoscopes, however, is rather slow and can only be applied to isolated, typically fixed (i.e. dead) cells rather than biomedically relevant tissues. Also, newcomers to the field need to familiarize themselves with a whole new set of potential problems that might arise in the use of optical nanoscopy, such as image reconstruction-related artifacts to name just one example.This is an area of research where European enterprises are very active. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in DeLIVER's ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained, and mobile ESRs will have greatly enhanced career prospects. The training in novel physical methods with highly relevant experience in the biomedical sciences will allow them to confidently navigate at the interface of academic, clinical and private sector research.


year authors and title journal last update
List of publications.
2019 Adrien Descloux, Marcel Müller, Vytautas Navikas, Andreas Markwirth, Robin van den Eynde, Tomas Lukes, Wolfgang Hübner, Theo Lasser, Aleksandra Radenovic, Peter Dedecker, Thomas Huser
High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism
published pages: 143-148, ISSN: 2192-8614, DOI: 10.1515/nanoph-2019-0346
Nanophotonics 9/1 2020-03-05
2019 Robin Van den Eynde, Alice Sandmeyer, Wim Vandenberg, Sam Duwé, Wolfgang Hübner, Thomas Huser, Peter Dedecker, Marcel Müller
Quantitative comparison of camera technologies for cost-effective super-resolution optical fluctuation imaging (SOFI)
published pages: 44001, ISSN: 2515-7647, DOI: 10.1088/2515-7647/ab36ae
Journal of Physics: Photonics 1/4 2020-03-05
2019 Andreas Markwirth, Mario Lachetta, Viola Mönkemöller, Rainer Heintzmann, Wolfgang Hübner, Thomas Huser, Marcel Müller
Video-rate multi-color structured illumination microscopy with simultaneous real-time reconstruction
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12165-x
Nature Communications 10/1 2020-03-05
2020 Cihang Kong, Christian Pilger, Henning Hachmeister, Xiaoming Wei, Tom H. Cheung, Cora S. W. Lai, Nikki P. Lee, Kevin. K. Tsia, Kenneth K. Y. Wong, Thomas Huser
High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser
published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-020-0259-2
Light: Science & Applications 9/1 2020-03-05
2020 NIKHIL JAYAKUMAR, Azeem Ahmad, Dalip Mehta, Balpreet Ahluwalia
Sampling moiré method: a tool for sensing quadratic phase distortion and its correction for accurate quantitative phase microscopy
published pages: , ISSN: 1094-4087, DOI: 10.1364/oe.383461
Optics Express 2020-03-05
2018 Cristina I. Øie, Viola Mönkemöller, Wolfgang Hübner, Mark Schüttpelz, Hong Mao, Balpreet S. Ahluwalia, Thomas R. Huser, Peter McCourt
New ways of looking at very small holes – using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations
published pages: 575-596, ISSN: 2192-8614, DOI: 10.1515/nanoph-2017-0055
Nanophotonics 7/3 2020-02-21
2018 Viola Mönkemöller, Hong Mao, Wolfgang Hübner, Gianina Dumitriu, Peter Heimann, Gahl Levy, Thomas Huser, Barbara Kaltschmidt, Christian Kaltschmidt, Cristina I. Øie
Primary rat LSECs preserve their characteristic phenotype after cryopreservation
published pages: 10, ISSN: 2045-2322, DOI: 10.1038/s41598-018-32103-z
Scientific Reports 8/1 2020-02-21
2019 Lothar Schermelleh, Alexia Ferrand, Thomas Huser, Christian Eggeling, Markus Sauer, Oliver Biehlmaier, Gregor P. C. Drummen
Super-resolution microscopy demystified
published pages: 72-84, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0251-8
Nature Cell Biology 21/1 2020-02-21

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