Opendata, web and dolomites

PUNCTUATION SIGNED

Pervasive Upstream Non-Coding Transcription Underpinning Adaptation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PUNCTUATION project word cloud

Explore the words cloud of the PUNCTUATION project. It provides you a very rough idea of what is the project "PUNCTUATION" about.

transcribes    interference    itself    cold    roles    organisms    gene    tti    dissect    pol    differ    profiles    expertise    downstream    environmental    whereas    life    transcribed    trigger    functions    transcriptional    tandem    independent    indicates    systematic    molecular    fidelity    throughput    stage    lncrna    rna    polymerase    popular    material    instructs    genetic    reconciling    cycles    upstream    ing    act    sequences    guided    blueprint    postulates    solutions    equivalent    punctuation    simplification    fraction    promises    changing    specify    elicit    though    hypothesis    stages    decades    reported    events    repress    reveal    group    yields    basis    pervasive    mostly    variability    organismal    genomes    genomic    plants    engaging    human    hallmarks    transcriptomics    curiously    expression    promoters    instruct    97    case    protein    transcription    plant    dna    characterization    units    first    marks    molecules    junk    anticipate    separation    leaves    lacking    coding    leader    inform    ago    functional    architecture   

Project "PUNCTUATION" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙499˙952 €
 EC max contribution 1˙499˙952 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙499˙952.00

Map

 Project objective

Genomic DNA represents the blueprint of life: it instructs solutions to challenges during life cycles of organisms. Curiously DNA in higher organisms is mostly non-protein coding (e.g. 97% in human). The popular “junk-DNA” hypothesis postulates that this non-coding DNA is non-functional. However, high-throughput transcriptomics indicates that this may be an over-simplification as most non-coding DNA is transcribed. This pervasive transcription yields two molecular events that may be functional: 1.) resulting long non-coding RNA (lncRNA) molecules, and 2.) the act of pervasive transcription itself. Whereas lncRNA sequences and functions differ on a case-by-case basis, RNA polymerase II (Pol II) transcribes most lncRNA. Pol II activity leaves molecular marks that specify transcription stages. The profiles of stage-specific activities instruct separation and fidelity of transcription units (genomic punctuation). Pervasive transcription affects genomic punctuation: upstream lncRNA transcription over gene promoters can repress downstream gene expression, also referred to as tandem Transcriptional Interference (tTI). Even though tTI was first reported decades ago a systematic characterization of tTI is lacking. Guided by my expertise in lncRNA transcription I recently identified the genetic material to dissect tTI in plants as an independent group leader. My planned research promises to reveal the genetic architecture and the molecular hallmarks defining tTI in higher organisms. Environmental lncRNA transcription variability may trigger tTI to promote organismal responses to changing conditions. We will address the roles of tTI in plant cold response to test this hypothesis. I anticipate our findings to inform on the fraction of pervasive transcription engaging in tTI. My proposal promises to advance our understanding of genomes by reconciling how the transcription of variable non-coding DNA sequences can elicit equivalent functions.

 Publications

year authors and title journal last update
List of publications.
2019 Mathias Nielsen, Ryan Ard, Xueyuan Leng, Maxim Ivanov, Peter Kindgren, Vicent Pelechano, Sebastian Marquardt
Transcription-driven chromatin repression of Intragenic transcription start sites
published pages: e1007969, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007969
PLOS Genetics 15/2 2019-08-29
2018 Peter Kindgren, Ryan Ard, Maxim Ivanov, Sebastian Marquardt
Transcriptional read-through of the long non-coding RNA SVALKA governs plant cold acclimation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07010-6
Nature Communications 9/1 2019-08-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PUNCTUATION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PUNCTUATION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

TRUST (2018)

Truth and Semantics

Read More