Opendata, web and dolomites

RetinalRepurposing SIGNED

Deciphering the computations underlying visual processing: Repurposing of retinal cells and how they are decoded by the visual thalamus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RetinalRepurposing project word cloud

Explore the words cloud of the RetinalRepurposing project. It provides you a very rough idea of what is the project "RetinalRepurposing" about.

ganglion    decodes    cortex    question    rgc    property    preference    core    direction    pioneer    depart    encoded    discovery    complexity    retina    adjustments    selective    groundbreaking    lateral    connectivity    encodes    discovered    computations    connections    contrasts    subtypes    mechanisms    directional    gain    scene    modality    triggers    simultaneous    repurposing    downstream    emerges    precise    types    mapping    nucleus    became    consistent    cells    geniculate    altered    pave    constantly    exposed    tuning    light    code    dynamic    functional    interpret    despite    raises    vision    30    changing    electrophysiology    representation    notion    dynamics    newly    provides    repurposed    rgcs    neurons    fixed    elucidate    world    reorient    motion    recordings    begins    lgn    first    critical    reveal    stable    imaging    gives    visual    mouse    revealed    techniques    dramatic    time    edges    perception    retinal    polarity    resolve    off    deciphering    hardwired   

Project "RetinalRepurposing" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙494˙000 €
 EC max contribution 1˙494˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙494˙000.00

Map

 Project objective

Visual processing begins in the retina, with ~30 types of retinal ganglion cells (RGCs), each encodes a specific visual modality, such as edges or motion. A major challenge for deciphering the visual code is mapping the connections between each RGC and its target neurons, such as in the lateral geniculate nucleus (LGN) and, via the LGN, the visual cortex. Recently, this challenge became even greater, as we and others revealed that the modality encoded by RGCs—traditionally considered a fixed hardwired property of each RGC type—can be altered. Direction selective RGCs reorient their directional tuning following visual adaptation, and other RGCs change their polarity preference (On/Off) as light level changes. These newly discovered dramatic changes in the core computations of RGCs depart from the known retinal adaptation which results in gain adjustments but no modality changes. We term them repurposing. The discovery of repurposing contrasts the widely-held notion that the retina provides a stable representation of the visual scene for downstream processing. This newly exposed level of complexity in the retinal code raises a critical question for our understanding of vision: How do retinal targets interpret the dynamic retinal code and how, despite such dynamics, a consistent representation of the visual scene emerges? We will use state-of-the-art electrophysiology and imaging techniques, and pioneer an approach for simultaneous retinal imaging and LGN recordings, to reveal how the mouse early visual system processes the changing visual information. We will elucidate the subtypes of repurposed RGCs, triggers for repurposing and their mechanisms. We will resolve, for the first time, the precise functional connectivity between subtypes of RGCs and LGN neurons, and determine how the LGN decodes retinal repurposing. Our groundbreaking research will pave the path for understanding how visual processing in a constantly changing world gives rise to a consistent perception.

 Publications

year authors and title journal last update
List of publications.
2018 Rebekah A. Warwick, Nathali Kaushansky, Nimrod Sarid, Amir Golan, Michal Rivlin-Etzion
Inhomogeneous Encoding of the Visual Field in the Mouse Retina
published pages: 655-665.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.01.016
Current Biology 28/5 2019-06-06
2018 Michal Rivlin-Etzion, William N. Grimes, Fred Rieke
Flexible Neural Hardware Supports Dynamic Computations in Retina
published pages: 224-237, ISSN: 0166-2236, DOI: 10.1016/j.tins.2018.01.009
Trends in Neurosciences 41/4 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RETINALREPURPOSING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "RETINALREPURPOSING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More  

HOLI (2019)

Deep Learning for Holistic Inference

Read More