Opendata, web and dolomites


IN VItro Cavitation Through UltraSound

Total Cost €


EC-Contrib. €






 INVICTUS project word cloud

Explore the words cloud of the INVICTUS project. It provides you a very rough idea of what is the project "INVICTUS" about.

degenerative    trials    simplification    vitro    drug    tissues    compounds    inception    proceeding    made    undergo    platform    enhancement    biomimetic    size    physiological    societal    euros    interactions    layer    animal    dimensional    biologists    actual    micro    healthcare    annual    cells    organisational    experimentation    cavitation    enormous    consuming    reversible    perfusion    exerted    fidelity    cross    evident    times    confirmed    stress    blood    permeability    bubbles    reproduce    inability    oscillations    extended    market    time    enhanced    volume    avoiding    ethical    correct    economical    few    clinicians    generally    local    substantial    expensive    tools    injected    reproducible    models    bic    provides    channels    investment    limiting    exploits    economic    vascular    rate    diseases    erc    humans    endothelial    pharmacologists    irradiation    ultrasound    pursed    shear    featuring    diseased    geometry    bbb    healthy    vivo    mostly    adg    collapse    brain    localised    endothelium    turnkey    realistic    originates    desirable    billion    almost    device    appropriate    disorders    clinical    800    hardly    central    barrier    savings    fluidic    biochemical    cns    invictus    words    bloodstream    company    nervous    alter   

Project "INVICTUS" data sheet

The following table provides information about the project.


Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Disorders of the central nervous system (CNS) contribute almost 800 billion euros in annual European healthcare costs. New compounds, effective in animal models, hardly work in humans, mostly due to the inability to cross the Brain Blood Barrier (BBB). In these conditions cost-effective tools to alter BBB and, more generally, endothelial layer permeability is desirable before proceeding to expensive and time-consuming animal studies. INVICTUS (IN VItro Cavitation Through UltraSound) originates within the ERC-AdG project Bubbles from Inception to Collapse (BIC) and concerns the development of a biomimetic micro-fluidic platform to be made turnkey available to biologists, clinicians and pharmacologists. The integrated platform exploits endothelial layer permeability enhancement by cavitation bubbles and provides an integrated, low cost platform to develop cavitation enhanced drug delivery under well controlled and reproducible conditions. Its potential is significant, given the well known societal and economical impact of degenerative diseases and the enormous investment and the long times of pre-clinical trials, as confirmed by a leading company operating in the field. Limiting/avoiding animal experimentation has an evident ethical impact and is associated with substantial economic savings and organisational simplification. In few words, micro-bubbles injected into the bloodstream undergo volume oscillations under localised ultrasound irradiation, with local reversible permeability enhancement of the endothelium. Already pursed in in vivo animal models, this approach is extended here to a high-fidelity, in vitro biomimetic device that will bring to market new crucial features such as the three-dimensional geometry of realistic-size vascular channels featuring an actual endothelial barrier, the correct perfusion rate, the appropriate physiological shear stress exerted on the endothelial cells and the ability to reproduce biochemical interactions between different, healthy and diseased, tissues.


year authors and title journal last update
List of publications.
2019 Giulia Silvani, Chiara Scognamiglio, Davide Caprini, Luca Marino, Mauro Chinappi, Giorgia Sinibaldi, Giovanna Peruzzi, Mohammad F. Kiani, Carlo M. Casciola
Reversible Cavitation-Induced Junctional Opening in an Artificial Endothelial Layer
published pages: , ISSN: , DOI:
Small 2020-01-16
2018 Giovanna Peruzzi, Giorgia Sinibaldi, Giulia Silvani, Giancarlo Ruocco, Carlo Massimo Casciola
Perspectives on cavitation enhanced endothelial layer permeability
published pages: 83-93, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2018.02.027
Colloids and Surfaces B: Biointerfaces 168 2020-01-16

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INVICTUS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INVICTUS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NeuroMag (2019)

The Neurological Basis of the Magnetic Sense

Read More  

Life-Inspired (2019)

Life-inspired complex molecular systems controlled by enzymatic reaction networks

Read More  

IMPACCT (2019)

Improved Patient Care by Combinatorial Treatment

Read More