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IN VItro Cavitation Through UltraSound

Total Cost €


EC-Contrib. €






 INVICTUS project word cloud

Explore the words cloud of the INVICTUS project. It provides you a very rough idea of what is the project "INVICTUS" about.

economical    inception    substantial    barrier    realistic    times    micro    market    societal    proceeding    platform    featuring    annual    drug    appropriate    desirable    device    local    pursed    layer    invictus    endothelium    shear    diseases    fluidic    dimensional    bloodstream    healthy    euros    humans    experimentation    nervous    perfusion    reproduce    savings    ethical    investment    alter    clinical    ultrasound    billion    oscillations    vascular    company    turnkey    hardly    compounds    physiological    biochemical    biologists    blood    bubbles    economic    central    adg    enormous    irradiation    few    mostly    vivo    actual    cells    cross    size    localised    diseased    healthcare    time    vitro    bic    exerted    biomimetic    cavitation    limiting    clinicians    animal    almost    reversible    brain    made    volume    originates    cns    correct    pharmacologists    endothelial    trials    injected    bbb    erc    avoiding    geometry    organisational    800    interactions    extended    channels    stress    simplification    models    words    inability    consuming    rate    generally    disorders    tissues    fidelity    exploits    confirmed    permeability    undergo    tools    collapse    provides    expensive    degenerative    reproducible    enhanced    enhancement    evident   

Project "INVICTUS" data sheet

The following table provides information about the project.


Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Disorders of the central nervous system (CNS) contribute almost 800 billion euros in annual European healthcare costs. New compounds, effective in animal models, hardly work in humans, mostly due to the inability to cross the Brain Blood Barrier (BBB). In these conditions cost-effective tools to alter BBB and, more generally, endothelial layer permeability is desirable before proceeding to expensive and time-consuming animal studies. INVICTUS (IN VItro Cavitation Through UltraSound) originates within the ERC-AdG project Bubbles from Inception to Collapse (BIC) and concerns the development of a biomimetic micro-fluidic platform to be made turnkey available to biologists, clinicians and pharmacologists. The integrated platform exploits endothelial layer permeability enhancement by cavitation bubbles and provides an integrated, low cost platform to develop cavitation enhanced drug delivery under well controlled and reproducible conditions. Its potential is significant, given the well known societal and economical impact of degenerative diseases and the enormous investment and the long times of pre-clinical trials, as confirmed by a leading company operating in the field. Limiting/avoiding animal experimentation has an evident ethical impact and is associated with substantial economic savings and organisational simplification. In few words, micro-bubbles injected into the bloodstream undergo volume oscillations under localised ultrasound irradiation, with local reversible permeability enhancement of the endothelium. Already pursed in in vivo animal models, this approach is extended here to a high-fidelity, in vitro biomimetic device that will bring to market new crucial features such as the three-dimensional geometry of realistic-size vascular channels featuring an actual endothelial barrier, the correct perfusion rate, the appropriate physiological shear stress exerted on the endothelial cells and the ability to reproduce biochemical interactions between different, healthy and diseased, tissues.


year authors and title journal last update
List of publications.
2019 Giulia Silvani, Chiara Scognamiglio, Davide Caprini, Luca Marino, Mauro Chinappi, Giorgia Sinibaldi, Giovanna Peruzzi, Mohammad F. Kiani, Carlo M. Casciola
Reversible Cavitation-Induced Junctional Opening in an Artificial Endothelial Layer
published pages: , ISSN: , DOI:
Small 2020-01-16
2018 Giovanna Peruzzi, Giorgia Sinibaldi, Giulia Silvani, Giancarlo Ruocco, Carlo Massimo Casciola
Perspectives on cavitation enhanced endothelial layer permeability
published pages: 83-93, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2018.02.027
Colloids and Surfaces B: Biointerfaces 168 2020-01-16

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