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EDIReX SIGNED

EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Total Cost €

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EC-Contrib. €

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Partnership

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 EDIReX project word cloud

Explore the words cloud of the EDIReX project. It provides you a very rough idea of what is the project "EDIReX" about.

efficient    cross    scientific    clinical    immunodeficient    vitro    exploratory    interoperability    reliability    molecular    patient    cutting    ta    quality    performance    structuring    optimal    entail    biobanking    pharmacological    pronged    edge    pdxs    visualisation    ethics    capitalising    service    query    diversity    pdx    cryopreserved    trials    nas    shared    parties    cells    patients    samples    cooperation    discovery    sustainability    industrial    data    mainly    oncology    trial    provision    recapitulate    networking    tools    academic    outreach    mouse    embraced    animal    transplanting    drug    platforms    inter    orthotopic    standard    tumour    infrastructures    models    mice    national    services    preclinical    infrastructure    backed    therapeutic    complexity    xenografts    public    counteracting    centred    plans    experimentation    properly    validation    tumours    biomarker    laboratory    attrition    annotation    harmonise    portal    rates    efficacy    edirex    joint    assets    humanised    area    maximised    global    storage    community    human    establishment    adoption    fragments    structured    trans    cancer   

Project "EDIReX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TORINO 

Organization address
address: VIA GIUSEPPE VERDI 8
city: TORINO
postcode: 10124
website: www.unito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.europdx.eu
 Total cost 5˙156˙198 €
 EC max contribution 5˙156˙198 € (100%)
 Programme 1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional  research infrastructures of European interest)
 Code Call H2020-INFRAIA-2017-1-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) coordinator 596˙143.00
2    Masarykova univerzita CZ (BRNO STRED) participant 473˙250.00
3    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON ES (BARCELONA) participant 453˙457.00
4    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 433˙497.00
5    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 429˙325.00
6    INSTITUT CURIE FR (PARIS) participant 408˙885.00
7    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 390˙887.00
8    SEEDING SCIENCE FR (PARIS) participant 381˙933.00
9    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 381˙343.00
10    OCELLO BV NL (LEIDEN) participant 231˙152.00
11    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 214˙256.00
12    KAIROS3D SRL IT (TORINO) participant 213˙375.00
13    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) participant 170˙607.00
14    INSTITUT CATALA D'ONCOLOGIA ES (L'HOSPITALET DEL LLOBREGAT) participant 121˙146.00
15    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 96˙971.00
16    BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC) AT (GRAZ) participant 70˙558.00
17    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 38˙995.00
18    HOSPITAL UNIVERSITARIO DE FUENLABRADA ES (FUENLABRADA) participant 27˙287.00
19    ISTITUTO EUROPEO DI ONCOLOGIA SRL IT (MILANO) participant 23˙125.00

Map

 Project objective

Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.

 Deliverables

List of deliverables.
Outline of the information recorded in a “PDX Passport” Documents, reports 2020-03-18 19:01:26

Take a look to the deliverables list in detail:  detailed list of EDIReX deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Enzo Medico, Emilie Vinolo
EurOPDX Data Portal: a repository of patient-derived xenograft models
published pages: , ISSN: , DOI: 10.6019/tol.europdx-w.2019.00001.1
Webinar 2020-03-18
2019 Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D\'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu
A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits.
published pages: canres.1166.2019, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-19-1166
Cancer Research 2020-03-18
2019 Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price
Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development
published pages: , ISSN: , DOI:
AACR Annual Meeting 2019 Online Proceedings 2020-03-18
2019 Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti
Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research
published pages: , ISSN: 1758-0463, DOI: 10.1093/database/baz080
Database 2019 2020-03-18
2018 E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19. 1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre, University of Cambridge, Cambridge, United Kingdom; 3Royal College of Surgeons in Ireland, Physiology & Medical Physics Dept, Dublin, Ireland; 4Manchester Cancer Research Centre, University of Manchester, Breast Biology Group, Division of Cancer Sciences, Manchester, United Kingdom; 5University Medical Centre Groningen, University of Groningen, Medical Oncology, Cancer Research Centre Groningen, Groningen, Netherlands; 6The Netherlands Cancer Institute, Division of Molecular Pathology, Oncode Institute, Amsterdam, Netherlands; 7Masarykova Univerzita, Institute of Computer Science, Brno, Czech Republic; 8Oslo University Hospital, Institute for Cancer Research, Oslo, Norway; 9Biobanking and BioMolecular resources Research Infrastructure, European Research Infrastructure Consortium, Graz, Austria; 10European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom; 11European Institute of Oncology, Department of Experimental Oncology, Milan, Italy; 12Vall d’Hebron Institute of Oncology and CIBERONC, Barcelona, Spain; 13Ocello bv, Leiden, Netherlands; 14Katholieke Universiteit Leuven, TRACE PDTX Platform, Leuven, Belgium; 15Institut Curie, PSL Research University, Department of Translational Research, Paris, France; 16Hospital de Fuenlabrada, Department of Medical Oncology, Fuenlabrada, Spain; 17Kairos3D srl, Turin, Italy; 18Catalan Institute of Oncology ICO, Bellvitge Biomedical Research Institute IDIBELL, Chemoresistance and Predictive Factors Laboratory, ProCURE, L’Hospitalet de Llobregat, Barcelona, Spain; 19University of Torino, Candiolo Cancer Institute IRCCS and Department of Oncology, Turin, Italy
The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models
published pages: 118, ISSN: 0959-8049, DOI:
European Journal of Cancer Volume 103S1, November 2018 2020-03-18
2018 E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo.
The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models
published pages: , ISSN: , DOI:
AACR Annual Meeting 2018 Online Proceedings 2020-03-18

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