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EDIReX SIGNED

EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts

Total Cost €

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EC-Contrib. €

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Partnership

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 EDIReX project word cloud

Explore the words cloud of the EDIReX project. It provides you a very rough idea of what is the project "EDIReX" about.

tumour    ta    therapeutic    mouse    services    quality    preclinical    edirex    cancer    pdx    nas    models    infrastructure   

Project "EDIReX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TORINO 

Organization address
address: VIA GIUSEPPE VERDI 8
city: TORINO
postcode: 10124
website: www.unito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 5˙156˙198 €
 EC max contribution 5˙156˙198 € (100%)
 Programme 1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional  research infrastructures of European interest)
 Code Call H2020-INFRAIA-2017-1-two-stage
 Funding Scheme /RIA
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) coordinator 596˙143.00
2    Masarykova univerzita CZ (BRNO STRED) participant 473˙250.00
3    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON ES (BARCELONA) participant 453˙457.00
4    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 433˙497.00
5    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 429˙325.00
6    INSTITUT CURIE FR (PARIS) participant 408˙885.00
7    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 390˙887.00
8    SEEDING SCIENCE FR (PARIS) participant 381˙933.00
9    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 381˙343.00
10    OCELLO BV NL (LEIDEN) participant 231˙152.00
11    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 214˙256.00
12    KAIROS3D SRL IT (TORINO) participant 213˙375.00
13    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) participant 170˙607.00
14    INSTITUT CATALA D'ONCOLOGIA ES (L'HOSPITALET DEL LLOBREGAT) participant 121˙146.00
15    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 96˙971.00
16    BIOBANKS AND BIOMOLECULAR RESOURCESRESEARCH INFRASTRUCTURE CONSORTIUM(BBMRI-ERIC) AT (GRAZ) participant 70˙558.00
17    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 38˙995.00
18    HOSPITAL UNIVERSITARIO DE FUENLABRADA ES (FUENLABRADA) participant 27˙287.00
19    ISTITUTO EUROPEO DI ONCOLOGIA SRL IT (MILANO) participant 23˙125.00

Mappa

 Project objective

Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "EDIREX" are provided by the European Opendata Portal: CORDIS opendata.

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