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ImmunAID SIGNED

Immunome project consortium for AutoInflammatory Disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 ImmunAID project word cloud

Explore the words cloud of the ImmunAID project. It provides you a very rough idea of what is the project "ImmunAID" about.

biological    rare    patient    undiagnosed    community    ern    medical    immunaid    rapid    supervised    diagnostic    combined    algorithm    diseases    leads    clinicians    extensive    experts    spectrum    autoinflammatory    interdisciplinary    hypothesis    diagnosis    run    bioinformatics    dysregulation    classification    omics    samples    inflammation    turning    conduct    identification    thanks    immune    exploring    generate    innovation    treatments    independent    disentangle    semi    inadequate    resolution    networks    tentative    advocacy    accurate    innate    link    externally    characterised    said    immunology    daily    gene    goals    biomarker    science    cohorts    decision    validated    implementable    microbiome    multiomics    collected    delay    clinical    assays    clustering    unspecific    rita    groups    systemic    centralised    patients    monogenic    biomarkers    data    discovery    unbiased    parallel    inflammasome    plan    protein    symptoms    caused    guideline    founder    bodies    transcript    proactive    forming    strategy    pathogenesis    disorders    600    efficient   

Project "ImmunAID" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 15˙835˙851 €
 EC max contribution 15˙835˙851 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2017-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 3˙189˙482.00
2    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 2˙568˙028.00
3    VIB BE (ZWIJNAARDE - GENT) participant 1˙256˙880.00
4    UNIVERSITE DE LIEGE BE (LIEGE) participant 1˙087˙053.00
5    UNIVERSITY OF LEEDS UK (LEEDS) participant 992˙228.00
6    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 897˙997.00
7    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) participant 796˙250.00
8    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 704˙966.00
9    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 632˙850.00
10    AMBIOTIS FR (TOULOUSE) participant 621˙250.00
11    INSTITUT CURIE FR (PARIS) participant 392˙500.00
12    ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK FR (PARIS) participant 391˙643.00
13    OWKIN FRANCE FR (PARIS) participant 383˙750.00
14    PANEPISTIMIO IOANNINON EL (IOANNINA) participant 369˙690.00
15    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 342˙500.00
16    UNIVERSITE DE GENEVE CH (GENEVE) participant 321˙465.00
17    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 273˙168.00
18    CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE BE (LIEGE) participant 151˙000.00
19    MANDANOVA FR (CASTANET-TOLOSAN) participant 142˙818.00
20    OSPEDALE PEDIATRICO BAMBINO GESU IT (ROMA) participant 102˙840.00
21    FMF & AID GLOBAL ASSOCIATION CH (BRUTTISELLEN) participant 93˙750.00
22    HOSPITAL SANT JOAN DE DÉU ES (ESPLUGUES DE LLOBREGAT) participant 44˙000.00
23    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 35˙750.00
24    HACETTEPE UNIVERSITESI TR (CANKAYA ANKARA) participant 32˙740.00
25    UNIVERZITETNI KLINICNI CENTER LJUBLJANA SI (LJUBLJANA) participant 11˙250.00

Map

 Project objective

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

 Publications

year authors and title journal last update
List of publications.
2019 Flora Magnotti, Lucie Lefeuvre, Sarah Benezech, Tiphaine Malsot, Louis Waeckel, Amandine Martin, Sébastien Kerever, Daria Chirita, Marine Desjonqueres, Agnès Duquesne, Mathieu Gerfaud‐Valentin, Audrey Laurent, Pascal Sève, Michel‐Robert Popoff, Thierry Walzer, Alexandre Belot, Yvan Jamilloux, Thomas Henry
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients
published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201910547
EMBO Molecular Medicine 11/11 2020-04-11
2019 Emely Verweyen, Dirk Holzinger, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Peter Pickkers, Sabrin Albeituni, Katherine Verbist, Kim E Nichols, Grant Schulert, Alexei Grom, Dirk Foell, Christoph Kessel
Synergistic TLR/IFNα/β-Signaling Facilitates Escape of IL-18 Expression from Endotoxin Tolerance
published pages: , ISSN: 1073-449X, DOI: 10.1164/rccm.201903-0659oc
American Journal of Respiratory and Critical Care Medicine 2020-04-11

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The information about "IMMUNAID" are provided by the European Opendata Portal: CORDIS opendata.

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