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ImmunAID SIGNED

Immunome project consortium for AutoInflammatory Disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 ImmunAID project word cloud

Explore the words cloud of the ImmunAID project. It provides you a very rough idea of what is the project "ImmunAID" about.

multiomics    biological    strategy    supervised    plan    diagnostic    treatments    groups    interdisciplinary    cohorts    community    unbiased    diseases    parallel    bioinformatics    clinicians    inflammation    advocacy    patient    monogenic    clinical    spectrum    rapid    resolution    disorders    collected    semi    protein    characterised    gene    externally    experts    biomarker    rare    600    diagnosis    independent    classification    discovery    proactive    forming    generate    leads    autoinflammatory    symptoms    tentative    caused    inadequate    identification    patients    pathogenesis    guideline    clustering    transcript    networks    ern    disentangle    exploring    accurate    dysregulation    innovation    efficient    microbiome    algorithm    validated    data    founder    turning    said    medical    samples    assays    omics    thanks    immunology    extensive    combined    link    biomarkers    centralised    systemic    undiagnosed    science    immune    unspecific    goals    daily    innate    bodies    rita    decision    delay    inflammasome    run    immunaid    conduct    hypothesis    implementable   

Project "ImmunAID" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 15˙835˙851 €
 EC max contribution 15˙835˙851 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2017-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 3˙189˙482.00
2    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 2˙568˙028.00
3    VIB BE (ZWIJNAARDE - GENT) participant 1˙256˙880.00
4    UNIVERSITE DE LIEGE BE (LIEGE) participant 1˙087˙053.00
5    UNIVERSITY OF LEEDS UK (LEEDS) participant 992˙228.00
6    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 897˙997.00
7    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) participant 796˙250.00
8    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 704˙966.00
9    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 632˙850.00
10    AMBIOTIS FR (TOULOUSE) participant 621˙250.00
11    INSTITUT CURIE FR (PARIS) participant 392˙500.00
12    ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK FR (PARIS) participant 391˙643.00
13    OWKIN FRANCE FR (PARIS) participant 383˙750.00
14    PANEPISTIMIO IOANNINON EL (IOANNINA) participant 369˙690.00
15    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 342˙500.00
16    UNIVERSITE DE GENEVE CH (GENEVE) participant 321˙465.00
17    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 273˙168.00
18    CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE BE (LIEGE) participant 151˙000.00
19    MANDANOVA FR (CASTANET-TOLOSAN) participant 142˙818.00
20    OSPEDALE PEDIATRICO BAMBINO GESU IT (ROMA) participant 102˙840.00
21    FMF & AID GLOBAL ASSOCIATION CH (BRUTTISELLEN) participant 93˙750.00
22    HOSPITAL SANT JOAN DE DÉU ES (ESPLUGUES DE LLOBREGAT) participant 44˙000.00
23    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 35˙750.00
24    HACETTEPE UNIVERSITESI TR (CANKAYA ANKARA) participant 32˙740.00
25    UNIVERZITETNI KLINICNI CENTER LJUBLJANA SI (LJUBLJANA) participant 11˙250.00

Map

 Project objective

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

 Publications

year authors and title journal last update
List of publications.
2019 Flora Magnotti, Lucie Lefeuvre, Sarah Benezech, Tiphaine Malsot, Louis Waeckel, Amandine Martin, Sébastien Kerever, Daria Chirita, Marine Desjonqueres, Agnès Duquesne, Mathieu Gerfaud‐Valentin, Audrey Laurent, Pascal Sève, Michel‐Robert Popoff, Thierry Walzer, Alexandre Belot, Yvan Jamilloux, Thomas Henry
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients
published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201910547
EMBO Molecular Medicine 11/11 2020-04-11
2019 Emely Verweyen, Dirk Holzinger, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Peter Pickkers, Sabrin Albeituni, Katherine Verbist, Kim E Nichols, Grant Schulert, Alexei Grom, Dirk Foell, Christoph Kessel
Synergistic TLR/IFNα/β-Signaling Facilitates Escape of IL-18 Expression from Endotoxin Tolerance
published pages: , ISSN: 1073-449X, DOI: 10.1164/rccm.201903-0659oc
American Journal of Respiratory and Critical Care Medicine 2020-04-11

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The information about "IMMUNAID" are provided by the European Opendata Portal: CORDIS opendata.

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