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TIMB3 SIGNED

Twin to Illuminate Metals in Biology and Biocatalysis through Biospectroscopy

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TIMB3" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 994˙367 €
 EC max contribution 994˙367 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-05-2017-Twinning
 Funding Scheme CSA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 687˙500.00
2    TECHNISCHE UNIVERSITAT BERLIN DE (BERLIN) participant 164˙375.00
3    CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE IT (FIRENZE) participant 142˙492.00

Map

 Project objective

TIMB3 offers the unique opportunity to capitalize on the existing infrastructure and human resources of ITQB-NOVA (Portugal) on biospectroscopy applied to the study of metals in biology to raise its scientific profile and achieve integration in the top league of research intensive institutions. The essential role of metals in biology is well recognized even by the general public (think of iron in blood). Notwithstanding, there is a growing appreciation of the potential of their study to radically transform our capacity to improve health and well-being and to develop novel biotechnological solutions to pressing environmental problems. This project emerges from successful test runs with the world class partners CIRMMP (Italy) and TUB (Germany), using networking instruments of narrower reach such as COST actions and bilateral partnerships. The scientific theme underlying the execution of TIMB3 is the enhancement of the capacity of ITQB-NOVA in performing world class research in biospectroscopy applied to metal homeostasis and trafficking and applied to bioinspired catalysis. The research profile of ITQB-NOVA staff will be raised by a combination of exchange missions with counterparts on the partner institutions, and structured training events on scientific and soft skills, including project writing and IP awareness. These activities will enable ITQB-NOVA to create a virtual platform for biospectroscopy to be used by non-specialists to learn the potential of this versatile group of methods to solve their specific research and development problems, broadening the social awareness to the capacities of biospectroscopy applied to the study of metals in biology. At the end of TIMB3, ITQB-NOVA will be able to enter international scientific consortia and compete for funding at the highest level establishing itself as a bona fide member of the top league of research intensive institutions.

 Publications

year authors and title journal last update
List of publications.
2020 Panagis Polykretis, Enrico Luchinat, Francesca Boscaro, Lucia Banci
Methylglyoxal interaction with superoxide dismutase 1
published pages: 101421, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101421
Redox Biology 30 2020-02-06
2019 Yulia Ilina, Christian Lorent, Sagie Katz, Jae-Hun Jeoung, Seigo Shima, Marius Horch, Ingo Zebger, Holger Dobbek
X-ray Crystallography and Vibrational Spectroscopy Reveal the Key Determinants of Biocatalytic Dihydrogen Cycling by [NiFe] Hydrogenases
published pages: 18710-18714, ISSN: 1433-7851, DOI: 10.1002/anie.201908258
Angewandte Chemie International Edition 58/51 2020-02-06
2019 Veronica Nasta, Stefano Da Vela, Spyridon Gourdoupis, Simone Ciofi-Baffoni, Dmitri I. Svergun, Lucia Banci
Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-55313-5
Scientific Reports 9/1 2020-02-06
2019 Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè
N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells
published pages: 828, ISSN: 2073-4409, DOI: 10.3390/cells8080828
Cells 8/8 2020-02-05
2019 Estelle Lebègue, Nazua L. Costa, Bruno M. Fonseca, Ricardo O. Louro, Frédéric Barrière
Electrochemical properties of pH-dependent flavocytochrome c3 from Shewanella putrefaciens adsorbed onto unmodified and catechol-modified edge plane pyrolytic graphite electrode
published pages: 113232, ISSN: 1572-6657, DOI: 10.1016/j.jelechem.2019.113232
Journal of Electroanalytical Chemistry 847 2020-02-05
2019 Catarina G. Fernandes, Diogo Martins, Guillem Hernandez, Ana L. Sousa, Carolina Freitas, Erin M. Tranfield, Tiago N. Cordeiro, Mónica Serrano, Charles. P. Moran, Adriano O. Henriques
Temporal and spatial regulation of protein cross-linking by the pre-assembled substrates of a Bacillus subtilis spore coat transglutaminase
published pages: e1007912, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007912
PLOS Genetics 15/4 2019-12-16
2019 Marco A. M. Videira, Susana A. L. Lobo, Filipa L. Sousa, Lígia M. Saraiva
Identification of the sirohaem biosynthesis pathway in Staphylococcus aureus
published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.15091
The FEBS Journal 2019-12-16
2019 Melanie Miller, William E. Robinson, Ana Rita Oliveira, Nina Heidary, Nikolay Kornienko, Julien Warnan, Inês A. C. Pereira, Erwin Reisner
Interfacing Formate Dehydrogenase with Metal Oxides for the Reversible Electrocatalysis and Solar-Driven Reduction of Carbon Dioxide
published pages: 4601-4605, ISSN: 1433-7851, DOI: 10.1002/anie.201814419
Angewandte Chemie International Edition 58/14 2019-12-16
2019 N. L. Costa, B. Hermann, V. Fourmond, M. M. Faustino, M. Teixeira, O. Einsle, C. M. Paquete, R. O. Louro
How Thermophilic Gram-Positive Organisms Perform Extracellular Electron Transfer: Characterization of the Cell Surface Terminal Reductase OcwA
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01210-19
mBio 10/4 2019-12-16
2019 Sandra M. Carvalho, Joana Marques, Carlos C. Romão, Lígia M. Saraiva
Metabolomics of Escherichia coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 Reveals Tricarboxylic Acid Cycle as Major Target
published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.00643-19
Antimicrobial Agents and Chemotherapy 63/10 2019-12-16
2019 Veronica Palma Delgado, Catarina M. Paquete, Gunnar Sturm, Johannes Gescher
Improvement of the electron transfer rate in Shewanella oneidensis MR-1 using a tailored periplasmic protein composition
published pages: 18-25, ISSN: 1567-5394, DOI: 10.1016/j.bioelechem.2019.04.022
Bioelectrochemistry 129 2019-12-16
2019 Sónia Zacarias, Adriana Temporão, Melisa del Barrio, Vincent Fourmond, Christophe Léger, Pedro M. Matias, Inês A. C. Pereira
A Hydrophilic Channel Is Involved in Oxidative Inactivation of a [NiFeSe] Hydrogenase
published pages: 8509-8519, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b02347
ACS Catalysis 9/9 2019-12-17
2019 Sandra P. Santos, Yang Yang, Margarida T. G. Rosa, Mafalda A. A. Rodrigues, Claire Bouthier De La Tour, Suzanne Sommer, Miguel Teixeira, Maria A. Carrondo, Peter Cloetens, Isabel A. Abreu, Célia V. Romão
The interplay between Mn and Fe in Deinococcus radiodurans triggers cellular protection during paraquat-induced oxidative stress
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-53140-2
Scientific Reports 9/1 2019-12-16
2019 Maria C. Martins, Célia V. Romão, Filipe Folgosa, Patrícia T. Borges, Carlos Frazão, Miguel Teixeira
How superoxide reductases and flavodiiron proteins combat oxidative stress in anaerobes
published pages: 36-60, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.01.051
Free Radical Biology and Medicine 140 2019-12-16
2019 Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè
N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells
published pages: 828, ISSN: 2073-4409, DOI: 10.3390/cells8080828
Cells 8/8 2019-12-16
2018 Américo G. Duarte, Teresa Catarino, Gaye F. White, Diana Lousa, Sinje Neukirchen, Cláudio M. Soares, Filipa L. Sousa, Thomas A. Clarke, Inês A. C. Pereira
An electrogenic redox loop in sulfate reduction reveals a likely widespread mechanism of energy conservation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07839-x
Nature Communications 9/1 2019-03-18
2018 Liliana S. O. Silva, Joana M. Baptista, Charlotte Batley, Simon C. Andrews, Lígia M. Saraiva
The Di-iron RIC Protein (YtfE) of Escherichia coli Interacts with the DNA-Binding Protein from Starved Cells (Dps) To Diminish RIC Protein-Mediated Redox Stress
published pages: , ISSN: 0021-9193, DOI: 10.1128/jb.00527-18
Journal of Bacteriology 200/24 2019-03-18

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