Opendata, web and dolomites


Biomarker Enterprise to Attack DKD - Sofia ref.: 115974

Total Cost €


EC-Contrib. €






Project "BEAt-DKD" data sheet

The following table provides information about the project.


Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 30˙163˙037 €
 EC max contribution 15˙085˙937 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2015-05-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 2˙110˙937.00
4    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 950˙000.00
7    UNIVERSITY OF LEEDS UK (LEEDS) participant 860˙000.00
9    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 655˙000.00
11    THE UNIVERSITY OF EXETER UK (EXETER) participant 555˙000.00
13    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 500˙000.00
14    CHU HOPITAUX DE BORDEAUX FR (TALENCE) participant 460˙000.00
16    TURUN YLIOPISTO FI (Turku) participant 320˙000.00
17    LIPOTYPE DE (DRESDEN) participant 300˙000.00
18    UNIVERSITY OF HULL UK (HULL) participant 250˙000.00
19    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 200˙000.00
22    ABBVIE INC US (NORTH CHICAGO IL) participant 0.00
23    ASTELLAS PHARMA EUROPE BV NL (LEIDEN) participant 0.00
24    Bayer Pharma AG DE (Berlin) participant 0.00
26    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
27    JDRF INTERNATIONAL US (NEW YORK) participant 0.00
28    NOVO NORDISK A/S DK (BAGSVAERD) participant 0.00


 Project objective

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.

The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.

Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.

The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.


List of deliverables.
White paper on strengths and weaknesses of using biomarker panels (or multiple biomarker scores) as risk stratifiers, as targets in drug development and as surrogate endpoints for regulatory approval Documents, reports 2020-04-08 21:02:42

Take a look to the deliverables list in detail:  detailed list of BEAt-DKD deliverables.


year authors and title journal last update
List of publications.
2019 Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling
published pages: 662-686, ISSN: 2190-5991, DOI: 10.1002/jcsm.12404
Journal of Cachexia, Sarcopenia and Muscle 10/3 2020-04-08
2019 Xiaomeng Xu, Karina Barreiro, Luca Musante, Oliver Kretz, Hanfei Lin, Hequn Zou, Tobias B. Huber, Harry Holthofer
Management of Tamm–Horsfall Protein for Reliable Urinary Analytics
published pages: 1900018, ISSN: 1862-8346, DOI: 10.1002/prca.201900018
PROTEOMICS – Clinical Applications 13/6 2020-04-08
2019 Hiddo J. L. Heerspink, Paul Perco, Skander Mulder, Johannes Leierer, Michael K. Hansen, Andreas Heinzel, Gert Mayer
Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease
published pages: 1154-1166, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4859-4
Diabetologia 62/7 2020-04-08
2019 Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber
Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics
published pages: 1551-1566.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.04.012
Cell Reports 27/5 2020-04-08
2019 Nienke M A Idzerda, Bergur V Stefansson, Michelle J Pena, David C Sjostrom, David C Wheeler, Hiddo J L Heerspink
Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfz064
Nephrology Dialysis Transplantation 2020-04-08
2019 Pengyun Li, Hussein N. Rubaiy, Gui‐Lan Chen, Thomas Hallett, Nawel Zaibi, Bo Zeng, Rahul Saurabh, Shang‐Zhong Xu
Mibefradil, a T‐type Ca 2+ channel blocker also blocks Orai channels by action at the extracellular surface
published pages: 3845-3856, ISSN: 0007-1188, DOI: 10.1111/bph.14788
British Journal of Pharmacology 176/19 2020-04-08
2019 Christian Koppelstaetter, Johannes Leierer, Michael Rudnicki, Julia Kerschbaum, Andreas Kronbichler, Anette Melk, Gert Mayer, Paul Perco
Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles
published pages: 843-853, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2019.06.019
Computational and Structural Biotechnology Journal 17 2020-04-08
2019 Michael Kammer, Andreas Heinzel, Jill A. Willency, Kevin L. Duffin, Gert Mayer, Kai Simons, Mathias J. Gerl, Christian Klose, Georg Heinze, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Mark I. McCarthy, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer
Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes
published pages: 1381-1388, ISSN: 0085-2538, DOI: 10.1016/j.kint.2019.07.025
Kidney International 96/6 2020-04-08
2019 Skander Mulder, Hiddo J. L. Heerspink, Manjula Darshi, Jiwan J. Kim, Gozewijn D. Laverman, Kumar Sharma, Michelle J. Pena
Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes
published pages: 2422-2428, ISSN: 1462-8902, DOI: 10.1111/dom.13823
Diabetes, Obesity and Metabolism 21/11 2020-04-08
2019 Paul Perco, Wenjun Ju, Julia Kerschbaum, Johannes Leierer, Rajasree Menon, Catherine Zhu, Matthias Kretzler, Gert Mayer, Michael Rudnicki
Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.128120
JCI Insight 4/12 2020-04-08
2019 Francesca Conserva, Mariagrazia Barozzino, Francesco Pesce, Chiara Divella, Annarita Oranger, Massimo Papale, Fabio Sallustio, Simona Simone, Luigi Laviola, Francesco Giorgino, Anna Gallone, Paola Pontrelli, Loreto Gesualdo
Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-47778-1
Scientific Reports 9/1 2020-04-08
2017 Markus M. Rinschen, Florian Grahammer, Ann-Kathrin Hoppe, Priyanka Kohli, Henning Hagmann, Oliver Kretz, Sabine Bertsch, Martin Höhne, Heike Göbel, Malte P. Bartram, Rajesh Kumar Gandhirajan, Marcus Krüger, Paul-Thomas Brinkkoetter, Tobias B. Huber, Martin Kann, Sara A. Wickström, Thomas Benzing, Bernhard Schermer
YAP-mediated mechanotransduction determines the podocyte’s response to damage
published pages: eaaf8165, ISSN: 1937-9145, DOI: 10.1126/scisignal.aaf8165
Science Signaling 10/474 2020-04-08
2017 Christoph Schell, Manuel Rogg, Martina Suhm, Martin Helmstädter, Dominik Sellung, Mako Yasuda-Yamahara, Oliver Kretz, Victoria Küttner, Hani Suleiman, Laxmikanth Kollipara, René P. Zahedi, Albert Sickmann, Stefan Eimer, Andrey S. Shaw, Albrecht Kramer-Zucker, Mariko Hirano-Kobayashi, Takaya Abe, Shinichi Aizawa, Florian Grahammer, Björn Hartleben, Jörn Dengjel, Tobias B. Huber
The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier
published pages: E4621-E4630, ISSN: 0027-8424, DOI: 10.1073/pnas.1617004114
Proceedings of the National Academy of Sciences 114/23 2020-04-08
2018 Dick de Zeeuw, Hiddo J L Heerspink, Meg Jardine, Vlado Perkovic
Renal trials in diabetes need a platform: time for a global approach?
published pages: 356-358, ISSN: 2213-8587, DOI: 10.1016/S2213-8587(17)30263-2
The Lancet Diabetes & Endocrinology 6/5 2020-04-08
2017 Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu
ORAI channels are critical for receptor-mediated endocytosis of albumin
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02094-y
Nature Communications 8/1 2020-04-08
2017 Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. Völker, Eva-Maria Schurek, Julie Binz, Martin Höhne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton
published pages: 2867-2878, ISSN: 1046-6673, DOI: 10.1681/ASN.2016101119
Journal of the American Society of Nephrology 28/10 2020-04-08
2017 Stefan Zschiedrich, Tillmann Bork, Wei Liang, Nicola Wanner, Kristina Eulenbruch, Stefan Munder, Björn Hartleben, Oliver Kretz, Simon Gerber, Matias Simons, Amandine Viau, Martine Burtin, Changli Wei, Jochen Reiser, Nadja Herbach, Maria-Pia Rastaldi, Clemens D Cohen, Pierre-Louis Tharaux, Fabiola Terzi, Gerd Walz, Markus Gödel, Tobias B Huber
Targeting mTOR Signaling Can Prevent the Progression of FSGS
published pages: 2144-2157, ISSN: 1046-6673, DOI: 10.1681/asn.2016050519
Journal of the American Society of Nephrology 28/7 2020-04-08
2018 Markus M. Rinschen, Markus Gödel, Florian Grahammer, Stefan Zschiedrich, Martin Helmstädter, Oliver Kretz, Mostafa Zarei, Daniela A. Braun, Sebastian Dittrich, Caroline Pahmeyer, Patricia Schroder, Carolin Teetzen, HeonYung Gee, Ghaleb Daouk, Martin Pohl, Elisa Kuhn, Bernhard Schermer, Victoria Küttner, Melanie Boerries, Hauke Busch, Mario Schiffer, Carsten Bergmann, Marcus Krüger, Friedhelm Hildebrandt, Joern Dengjel, Thomas Benzing, Tobias B. Huber
A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
published pages: 2495-2508, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.059
Cell Reports 23/8 2020-04-08
2018 Habib Hamidi, Matthias Kretzler
Systems biology approaches to identify disease mechanisms and facilitate targeted therapy in the management of glomerular disease
published pages: 1, ISSN: 1062-4821, DOI: 10.1097/MNH.0000000000000446
Current Opinion in Nephrology and Hypertension 2020-04-08
2018 Mako Yasuda-Yamahara, Manuel Rogg, Kosuke Yamahara, Jasmin I. Maier, Tobias B. Huber, Christoph Schell
AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes
published pages: e0200487, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200487
PLOS ONE 13/7 2020-04-08
2018 Marcos Wolf, Anneloes de Boer, Kanishka Sharma, Peter Boor, Tim Leiner, Gere Sunder-Plassmann, Ewald Moser, Anna Caroli, Neil Peter Jerome
Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper
published pages: ii41-ii50, ISSN: 0931-0509, DOI: 10.1093/ndt/gfy198
Nephrology Dialysis Transplantation 33/suppl_2 2020-04-08
2018 Laura Rennert, Stefan Zschiedrich, Lukas Sandner, Björn Hartleben, Sanja Cicko, Cemil Korcan Ayata, Charlotte Meyer, Andreas Zech, Robert Zeiser, Tobias B. Huber, Marco Idzko, Florian Grahammer
P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01589
Frontiers in Immunology 9 2020-04-08
2018 Nienke M.A. Idzerda, Michelle J. Pena, Hiddo J.L. Heerspink
Personalized medicine in diabetic kidney disease
published pages: 1, ISSN: 1062-4821, DOI: 10.1097/MNH.0000000000000447
Current Opinion in Nephrology and Hypertension 2020-04-08
2019 Paul Perco, Michelle Pena, Hiddo J.L. Heerspink, Gert Mayer
Multimarker Panels in Diabetic Kidney Disease: The Way to Improved Clinical Trial Design and Clinical Practice?
published pages: 212-221, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2018.12.001
Kidney International Reports 4/2 2020-04-08
2017 Ben Mellows, Robert Mitchell, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, Bernd Denecke, Luca Musante, Durrgah L. Ramachandra, Florence Debacq-Chainiaux, Harry Holthofer, Barbara Joch, Steve Ray, Darius Widera, Anna L. David, Tobias B. Huber, Joern Dengjel, Paolo De Coppi, Ketan Patel
Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis
published pages: 1316-1333, ISSN: 1547-3287, DOI: 10.1089/scd.2017.0089
Stem Cells and Development 26/18 2020-04-08
2017 Luca Musante, Dorota Tataruch-Weinert, Dontscho Kerjaschki, Michael Henry, Paula Meleady, Harry Holthofer
Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment
published pages: 1267896, ISSN: 2001-3078, DOI: 10.1080/20013078.2016.1267896
Journal of Extracellular Vesicles 6/1 2020-04-08
2018 Nienke M A Idzerda, Michelle J Pena, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J L Heerspink
Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy159
Nephrology Dialysis Transplantation 2020-04-08
2018 Paul Perco, Gert Mayer
Endogenous factors and mechanisms of renoprotection and renal repair
published pages: e12914, ISSN: 0014-2972, DOI: 10.1111/eci.12914
European Journal of Clinical Investigation 48/5 2020-04-08
2018 Nienke M. A. Idzerda, Frederik Persson, Michelle J. Pena, Barry M. Brenner, Patrick Brunel, Nish Chaturvedi, John J. McMurray, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J. L. Heerspink
N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk
published pages: , ISSN: 1462-8902, DOI: 10.1111/dom.13465
Diabetes, Obesity and Metabolism 2020-04-08
2018 Skander Mulder, Habib Hamidi, Matthias Kretzler, Wenjun Ju
An integrative systems biology approach for precision medicine in diabetic kidney disease
published pages: 6-13, ISSN: 1462-8902, DOI: 10.1111/dom.13416
Diabetes, Obesity and Metabolism 20 2020-04-08
2018 Martin Höhne, Christian K. Frese, Florian Grahammer, Claudia Dafinger, Giuliano Ciarimboli, Linus Butt, Julia Binz, Matthias J. Hackl, Mahdieh Rahmatollahi, Martin Kann, Simon Schneider, Mehmet M. Altintas, Bernhard Schermer, Thomas Reinheckel, Heike Göbel, Jochen Reiser, Tobias B. Huber, Rafael Kramann, Tamina Seeger-Nukpezah, Max C. Liebau, Bodo B. Beck, Thomas Benzing, Andreas Beyer, Markus M. Rinschen
Single-nephron proteomes connect morphology and function in proteinuric kidney disease
published pages: 1308-1319, ISSN: 0085-2538, DOI: 10.1016/j.kint.2017.12.012
Kidney International 93/6 2020-04-08
2017 Martin Helmstädter, Tobias B. Huber, Tobias Hermle
Using the Drosophila Nephrocyte to Model Podocyte Function and Disease
published pages: , ISSN: 2296-2360, DOI: 10.3389/fped.2017.00262
Frontiers in Pediatrics 5 2020-04-08
2018 Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
published pages: 361-369, ISSN: 2213-8587, DOI: 10.1016/S2213-8587(18)30051-2
The Lancet Diabetes & Endocrinology 6/5 2020-04-08
2017 Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna Köttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wheeler, Kai-Uwe Eckardt, Dwomoa Adu, Sanjay Kumar Agarwal, Mona Alrukhaimi, Hans-Joachim Anders, Gloria Ashuntantang, Shakti Basnet, Aminu K. Bello, Worawon Chailimpamontree, Ricardo Correa-Rotter, Jonathan Craig, Walter G. Douthat, Harold I. Feldman, Mohammad Reza Ganji, Guillermo Garcia-Garcia, Mohammed Benghanem Gharbi, David C. Harris, Vivekanand Jha, David W. Johnson, Rumeyza Kazancioglu, Robyn Langham, Zhi-Hong Liu, Ziad A. Massy, Masaomi Nangaku, Robert G. Nelson, Donal O\'Donoghue, Ikechi Okpechi, Roberto Pecoits-Filho, Neil R. Powe, Giuseppe Remuzzi, Charlotte Roberts, Jerome Rossert, Laura Sola, Benedicte Stengel, Ernest K. Sumaili M, Yusuke Suzuki, Tetsuhiro Tanaka, Sajja Tatiyanupanwong, Bernadette Thomas, Katrin Uhlig, Robert Walker, Sarah L. White, Andrzej Wiecek, Chih-Wei Yang
Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy
published pages: 1888-1917, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(17)30788-2
The Lancet 390/10105 2020-04-08
2017 Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad
Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition
published pages: 2664-2677, ISSN: 0006-4971, DOI: 10.1182/blood-2017-05-782102
Blood 130/24 2020-04-08
2018 Nicola Wanner, Julia Vornweg, Alexander Combes, Sean Wilson, Julia Plappert, Gesa Rafflenbeul, Victor G. Puelles, Raza-Ur Rahman, Timur Liwinski, Saskia Lindner, Florian Grahammer, Oliver Kretz, Mary E. Wlodek, Tania Romano, Karen M. Moritz, Melanie Boerries, Hauke Busch, Stefan Bonn, Melissa H. Little, Wibke Bechtel-Walz, Tobias B. Huber
DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation
published pages: 63-78, ISSN: 1046-6673, DOI: 10.1681/asn.2018070736
Journal of the American Society of Nephrology 30/1 2020-04-08
2018 Christoph Schell, Benedikt Sabass, Martin Helmstaedter, Felix Geist, Ahmed Abed, Mako Yasuda-Yamahara, August Sigle, Jasmin I. Maier, Florian Grahammer, Florian Siegerist, Nadine Artelt, Nicole Endlich, Dontscho Kerjaschki, Hans-Henning Arnold, Jörn Dengjel, Manuel Rogg, Tobias B. Huber
ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier
published pages: 741-757.e8, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.11.011
Developmental Cell 47/6 2020-04-08
2018 Sara Gonçalves, Julie Patat, Maria Clara Guida, Noelle Lachaussée, Christelle Arrondel, Martin Helmstädter, Olivia Boyer, Olivier Gribouval, Marie-Claire Gubler, Geraldine Mollet, Marlène Rio, Marina Charbit, Christine Bole-Feysot, Patrick Nitschke, Tobias B. Huber, Patricia G. Wheeler, Devon Haynes, Jane Juusola, Thierry Billette de Villemeur, Caroline Nava, Alexandra Afenjar, Boris Keren, Rolf Bodmer, Corinne Antignac, Matias Simons
A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies
published pages: e1007386, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007386
PLOS Genetics 14/5 2020-04-08
2017 Karina Barreiro, Harry Holthofer
Urinary extracellular vesicles. A promising shortcut to novel biomarker discoveries
published pages: 217-227, ISSN: 0302-766X, DOI: 10.1007/s00441-017-2621-0
Cell and Tissue Research 369/1 2020-04-08
2018 Nicholas M Selby, Peter J Blankestijn, Peter Boor, Christian Combe, Kai-Uwe Eckardt, Eli Eikefjord, Nuria Garcia-Fernandez, Xavier Golay, Isky Gordon, Nicolas Grenier, Paul D Hockings, Jens D Jensen, Jaap A Joles, Philip A Kalra, Bernhard K Krämer, Patrick B Mark, Iosif A Mendichovszky, Olivera Nikolic, Aghogho Odudu, Albert C M Ong, Alberto Ortiz, Menno Pruijm, Giuseppe Remuzzi, Jarle Rørvik, Sophie de Seigneux, Roslyn J Simms, Janka Slatinska, Paul Summers, Maarten W Taal, Harriet C Thoeny, Jean-Paul Vallée, Marcos Wolf, Anna Caroli, Steven Sourbron
Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA
published pages: ii4-ii14, ISSN: 0931-0509, DOI: 10.1093/ndt/gfy152
Nephrology Dialysis Transplantation 33/suppl_2 2020-04-08
2018 Hiddo J. L. Heerspink, James List, Vlado Perkovic
New clinical trial designs for establishing drug efficacy and safety in a precision medicine era
published pages: 14-18, ISSN: 1462-8902, DOI: 10.1111/dom.13417
Diabetes, Obesity and Metabolism 20 2020-04-08
2017 Maja T. Lindenmeyer, Matthias Kretzler
Renal biopsy-driven molecular target identification in glomerular disease
published pages: 1021-1028, ISSN: 0031-6768, DOI: 10.1007/s00424-017-2006-y
Pflügers Archiv - European Journal of Physiology 469/7-8 2020-04-08
2018 Amandine Viau, Frank Bienaimé, Kamile Lukas, Abhijeet P Todkar, Manuel Knoll, Toma A Yakulov, Alexis Hofherr, Oliver Kretz, Martin Helmstädter, Wilfried Reichardt, Simone Braeg, Tom Aschman, Annette Merkle, Dietmar Pfeifer, Verónica I Dumit, Marie‐Claire Gubler, Roland Nitschke, Tobias B Huber, Fabiola Terzi, Jörn Dengjel, Florian Grahammer, Michael Köttgen, Hauke Busch, Melanie Boerries, Gerd Walz, Antigoni Triantafyllopoulou, E Wolfgang Kuehn
Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney
published pages: e98615, ISSN: 0261-4189, DOI: 10.15252/embj.201798615
The EMBO Journal 37/15 2020-04-08
2018 Hans-Joachim Anders, Tobias B. Huber, Berend Isermann, Mario Schiffer
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease
published pages: 361-377, ISSN: 1759-5061, DOI: 10.1038/s41581-018-0001-y
Nature Reviews Nephrology 14/6 2020-04-08
2018 Banaja P. Dash, Tina M. Schnöder, Carolin Kathner, Juliane Mohr, Sönke Weinert, Carolin Herzog, Parimala Sonika Godavarthy, Costanza Zanetti, Florian Perner, Rüdiger Braun-Dullaeus, Björn Hartleben, Tobias B. Huber, Gerd Walz, Michael Naumann, Sarah Ellis, Valera Vasioukhin, Thilo Kähne, Daniela S. Krause, Florian H. Heidel
Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells
published pages: 1933-1944, ISSN: 0171-5216, DOI: 10.1007/s00432-018-2724-3
Journal of Cancer Research and Clinical Oncology 144/10 2020-04-08
2018 Kathryn L. Garner, Virginie M. S. Betin, Vanda Pinto, Mark Graham, Emmanuelle Abgueguen, Matt Barnes, David C. Bedford, Craig A. McArdle, Richard J. M. Coward
Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22233-9
Scientific Reports 8/1 2020-04-08
2018 Ellen M. Apperloo, Michelle J. Pena, Dick de Zeeuw, Petra Denig, Hiddo J. L. Heerspink
Individual variability in response to renin angiotensin aldosterone system inhibition predicts cardiovascular outcome in patients with type 2 diabetes: A primary care cohort study
published pages: 1377-1383, ISSN: 1462-8902, DOI: 10.1111/dom.13226
Diabetes, Obesity and Metabolism 20/6 2020-04-08
2017 Carole Henique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Léa Guyonnet, François Gaillard, Hélène Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legrès, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B. Huber, Laurent Mesnard, Olivia Lenoir, Pierre-Louis Tharaux
Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01885-7
Nature Communications 8/1 2020-04-08
2017 Matthew D. Breyer, Matthias Kretzler
Novel avenues for drug discovery in diabetic kidney disease
published pages: 65-74, ISSN: 1746-0441, DOI: 10.1080/17460441.2018.1398731
Expert Opinion on Drug Discovery 13/1 2020-04-08
2018 Hiddo J. L. Heerspink, Dick de Zeeuw
Treating diabetic complications; from large randomized clinical trials to precision medicine
published pages: 3-5, ISSN: 1462-8902, DOI: 10.1111/dom.13418
Diabetes, Obesity and Metabolism 20 2020-04-08
2019 J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-08235-1
Nature Communications 10/1 2020-04-08
2018 Paul Perco, Gert Mayer
Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information?
published pages: 308-310, ISSN: 0085-2538, DOI: 10.1016/j.kint.2017.10.026
Kidney International 93/2 2020-04-08
2017 M. Rogg, M. Yasuda-Yamahara, A. Abed, P. Dinse, M. Helmstädter, A. C. Conzelmann, J. Frimmel, D. Sellung, M. L. Biniossek, O. Kretz, F. Grahammer, O. Schilling, T. B. Huber, C. Schell
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-15844-1
Scientific Reports 7/1 2020-04-08
2018 Andreas Heinzel, Michael Kammer, Gert Mayer, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Peter Gilmour, Jonathan M. Wilson, Kevin L. Duffin, Moustafa Abdalla, Mark I. McCarthy, Georg Heinze, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer
Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes
published pages: 1947-1954, ISSN: 0149-5992, DOI: 10.2337/dc18-0532
Diabetes Care 41/9 2020-04-08
2017 Abigail C. Lay, Jenny A. Hurcombe, Virginie M. S. Betin, Fern Barrington, Ruth Rollason, Lan Ni, Lawrence Gillam, Grace M. E. Pearson, Mette V. Østergaard, Hellyeh Hamidi, Rachel Lennon, Gavin I. Welsh, Richard J. M. Coward
Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor
published pages: 2299-2311, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4394-0
Diabetologia 60/11 2020-04-08

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The information about "BEAT-DKD" are provided by the European Opendata Portal: CORDIS opendata.

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