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TRIM-NET SIGNED

Training network in drug discovery targeting TRIM Ubiquitin ligases in disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TRIM-NET" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRIESTE 

Organization address
address: PIAZZALE EUROPA 1
city: TRIESTE
postcode: 34127
website: www.units.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙203˙448 €
 EC max contribution 3˙203˙448 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRIESTE IT (TRIESTE) coordinator 522˙999.00
2    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 531˙239.00
3    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 531˙239.00
4    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 303˙172.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 274˙802.00
6    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) participant 274˙802.00
7    FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA IT (SAN GIOVANNI ROTONDO FG) participant 261˙499.00
8    KARLSRUHER INSTITUT FUER TECHNOLOGIE DE (KARLSRUHE) participant 252˙788.00
9    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 250˙904.00
10    CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCARL IT (TRIESTE) partner 0.00
11    Labcyte Ltd UK (Cannock) partner 0.00
12    OCELLO BV NL (LEIDEN) partner 0.00
13    PHARMATRAIN FEDERATION BE (BRUXELLES) partner 0.00
14    Ubiquigent Ltd UK (Dundee) partner 0.00

Map

 Project objective

The TRIM-NET innovative training programme will provide Early-Stage Researchers with the skills to identify novel therapeutic targets and develop the strategies to validate them in preclinical studies. Integrating complementary expertise and multidisciplinary approaches TRIM-NET aims to address this goal, focussing on the Tripartite motif (TRIM) family of Ubiquitin E3 ligases, which plays an important role in many physiological processes. The importance of the role of TRIM proteins in these processes is underpinned by their recognised involvement in many disease processes such as cancer, neurodegeneration and rare genetic diseases. As such, they are excellent targets for therapeutic manipulation. The TRIM-NET consortium created a critical mass with complementary and interdisciplinary expertise, from Life Science to Chemistry, around this family of proteins to identify and exploit common targeting strategies for translational applications. The consortium is designed to train a cohort of researchers in skills and expertise essential for biomedical research in the era of personalised medicine, focussing on determining how: i) TRIM proteins contribute to disease; ii) to develop strategies to modulate TRIM proteins activity; iii) to design high throughput screening assays for drug discovery. The training programme comprises 7 highly integrated work packages: 4 scientific and 3 dedicated to training, dissemination and management. The proposal consists of 12 individual research projects that will form the basis of the research training aspects for the ESR recruited to the programme. As the scientific work packages are highly integrated, recruited ESRs will avail of techniques and training opportunities, including secondments, across the work packages. Through a unique international partnership between academic and non-academic partners the TRIM-NET training programme will provide ESRs with skills that are essential for future biomedical research in industry and academia.

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