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CELL-in-CELL SIGNED

Understanding host cellular systems that drive an endosymbiotic interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CELL-in-CELL project word cloud

Explore the words cloud of the CELL-in-CELL project. It provides you a very rough idea of what is the project "CELL-in-CELL" about.

endosymbiosis    separated    phenomenon    endosymbioses    grown    nascent    event    huge    candidate    bursaria    little    harbours    driving    protist    green    diversify    core    shaping    evolution    organelles    adaptations    eukaryotes    endosymbiotic    relationship    separately    silencing    significantly    stable    functions    biological    life    drive    localisation    continually    genes    perturb    explore    form    genome    critical    changing    gene    knockdown    transfer    endosymbiont    roots    population    celled    generating    diversity    phototrophic    incubate    silenced    origin    reinitiated    recipient    algae    multiple    compartments    paramecium    evolutionary    trajectory    conduct    first    time    interaction    experiment    eukaryotic    rnai    followed    sequencing    screening    moments    tree    single    played    advancing    interactions    cell    proteins    diversification    complexity    encoded    sections    function    host    cellular    chart    fundamentally   

Project "CELL-in-CELL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙602˙483 €
 EC max contribution 2˙602˙483 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 2˙602˙483.00

Map

 Project objective

Endosymbiosis is a key phenomenon that has played a critical role in shaping biological diversity, driving gene transfer and generating cellular complexity. During the process of endosymbiosis, one cell is integrated within another to become a critical component of the recipient, changing its characteristics and allowing it to chart a distinct evolutionary trajectory. Endosymbiosis was fundamentally important to the origin and evolution of eukaryotic cellular complexity, because an endosymbiotic event roots the diversification of all known eukaryotes and endosymbiosis has continually driven the diversification of huge sections of the eukaryotic tree of life. Little is known about how nascent endosymbioses are established or how they go on to form novel cellular compartments known as endosymbiotic organelles. Paramecium bursaria is a single celled protist that harbours multiple green algae within to form a phototrophic endosymbiosis. This relationship is nascent as the partners can be separated, grown separately, and the endosymbiosis reinitiated. This project will identify, for the first time, the gene functions that enable one cell to incubate another within to form a stable endosymbiotic interaction. To identify and explore which host genes control endosymbiosis in P. bursaria we have developed RNAi silencing technology. In the proposed project we will conduct genome sequencing, followed by a large-scale RNAi knockdown screening experiment, to identify host genes that when silenced perturb the endosymbiont population. Having identified candidate genes, we will investigate the localisation and function of the host encoded proteins. This project will significantly change our current understanding of the evolutionary phenomenon of endosymbiosis by identifying the cellular adaptations that drive these interactions, advancing our understanding of how these important moments in evolution occur and how core cellular systems can diversify in function.

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