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Understanding host cellular systems that drive an endosymbiotic interaction

Total Cost €


EC-Contrib. €






 CELL-in-CELL project word cloud

Explore the words cloud of the CELL-in-CELL project. It provides you a very rough idea of what is the project "CELL-in-CELL" about.

separated    huge    reinitiated    paramecium    diversification    host    life    genes    time    critical    interaction    transfer    organelles    gene    diversify    compartments    phototrophic    complexity    incubate    silenced    shaping    changing    genome    played    sections    endosymbiosis    interactions    little    multiple    biological    roots    algae    candidate    phenomenon    function    core    endosymbiotic    knockdown    fundamentally    advancing    celled    experiment    grown    perturb    nascent    silencing    diversity    followed    cell    drive    significantly    green    stable    eukaryotes    proteins    adaptations    tree    bursaria    sequencing    rnai    evolutionary    generating    harbours    relationship    driving    population    event    endosymbioses    chart    encoded    explore    origin    trajectory    conduct    screening    first    endosymbiont    localisation    recipient    continually    functions    protist    moments    single    separately    form    evolution    cellular    eukaryotic   

Project "CELL-in-CELL" data sheet

The following table provides information about the project.


Organization address
city: EXETER
postcode: EX4 4QJ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙602˙483 €
 EC max contribution 2˙602˙483 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 2˙602˙483.00


 Project objective

Endosymbiosis is a key phenomenon that has played a critical role in shaping biological diversity, driving gene transfer and generating cellular complexity. During the process of endosymbiosis, one cell is integrated within another to become a critical component of the recipient, changing its characteristics and allowing it to chart a distinct evolutionary trajectory. Endosymbiosis was fundamentally important to the origin and evolution of eukaryotic cellular complexity, because an endosymbiotic event roots the diversification of all known eukaryotes and endosymbiosis has continually driven the diversification of huge sections of the eukaryotic tree of life. Little is known about how nascent endosymbioses are established or how they go on to form novel cellular compartments known as endosymbiotic organelles. Paramecium bursaria is a single celled protist that harbours multiple green algae within to form a phototrophic endosymbiosis. This relationship is nascent as the partners can be separated, grown separately, and the endosymbiosis reinitiated. This project will identify, for the first time, the gene functions that enable one cell to incubate another within to form a stable endosymbiotic interaction. To identify and explore which host genes control endosymbiosis in P. bursaria we have developed RNAi silencing technology. In the proposed project we will conduct genome sequencing, followed by a large-scale RNAi knockdown screening experiment, to identify host genes that when silenced perturb the endosymbiont population. Having identified candidate genes, we will investigate the localisation and function of the host encoded proteins. This project will significantly change our current understanding of the evolutionary phenomenon of endosymbiosis by identifying the cellular adaptations that drive these interactions, advancing our understanding of how these important moments in evolution occur and how core cellular systems can diversify in function.

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