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4-D nanoSCOPE SIGNED

Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 4-D nanoSCOPE project word cloud

Explore the words cloud of the 4-D nanoSCOPE project. It provides you a very rough idea of what is the project "4-D nanoSCOPE" about.

breathing    lack    function    small    vascular    dramatic    ex    animals    speed    disease    due    tools    monitoring    dynamics    compensate    characterization    inflammation    vitro    properly    remodeling    artefacts    subject    resolved    age    dimensions    learning    4d    complemented    revolutionizing    treatment    microscopy    local    injuries    sections    datasets    hampered    thoroughly    image    permitting    composition    resolution    quality    hormones    velocities    serial    combining    techniques    spatial    society    ray    hardware    diseases    impaired    considerable    nanoscope    osteoporosis    dimensional    morphology    structure    bone    images    chemical    twitching    consequent    pis    innovative    mice    occurrence    software    creatures    life    microscope    time    spectroscopy    transport    precision    op    ageing    imaging    ing    collaborators    revolutionized    vivo    series    productivity    thereby    permit    sufferers    international    strength    microstructure    first    acquisition    correlative    living   

Project "4-D nanoSCOPE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM ERLANGEN 

Organization address
address: MAXIMILIANSPLATZ 2
city: ERLANGEN
postcode: 91054
website: www.uk-erlangen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 12˙366˙635 €
 EC max contribution 12˙366˙635 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM ERLANGEN DE (ERLANGEN) coordinator 2˙837˙980.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 6˙773˙605.00
3    FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG DE (ERLANGEN) participant 2˙755˙050.00
4    HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH DE (BERLIN) participant 0.00

Map

 Project objective

Due to Europe's ageing society, there has been a dramatic increase in the occurrence of osteoporosis (OP) and related diseases. Sufferers have an impaired quality of life, and there is a considerable cost to society associated with the consequent loss of productivity and injuries. The current understanding of this disease needs to be revolutionized, but study has been hampered by a lack of means to properly characterize bone structure, remodeling dynamics and vascular activity. This project, 4D nanoSCOPE, will develop tools and techniques to permit time-resolved imaging and characterization of bone in three spatial dimensions (both in vitro and in vivo), thereby permitting monitoring of bone remodeling and revolutionizing the understanding of bone morphology and its function. To advance the field, in vivo high-resolution studies of living bone are essential, but existing techniques are not capable of this. By combining state-of-the art image processing software with innovative 'precision learning' software methods to compensate for artefacts (due e.g. to the subject breathing or twitching), and innovative X-ray microscope hardware which together will greatly speed up image acquisition (aim is a factor of 100), the project will enable in vivo X-ray microscopy studies of small animals (mice) for the first time. The time series of three-dimensional X-ray images will be complemented by correlative microscopy and spectroscopy techniques (with new software) to thoroughly characterize (serial) bone sections ex vivo. The resulting three-dimensional datasets combining structure, chemical composition, transport velocities and local strength will be used by the PIs and international collaborators to study the dynamics of bone microstructure. This will be the first time that this has been possible in living creatures, enabling an assessment of the effects on bone of age, hormones, inflammation and treatment.

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The information about "4-D NANOSCOPE" are provided by the European Opendata Portal: CORDIS opendata.

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