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4-D nanoSCOPE SIGNED

Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 4-D nanoSCOPE project word cloud

Explore the words cloud of the 4-D nanoSCOPE project. It provides you a very rough idea of what is the project "4-D nanoSCOPE" about.

ray    strength    microscope    remodeling    sections    combining    revolutionized    hampered    first    correlative    dramatic    innovative    structure    quality    injuries    resolution    microscopy    age    sufferers    tools    hardware    compensate    breathing    permit    composition    characterization    properly    velocities    spectroscopy    permitting    osteoporosis    revolutionizing    op    software    techniques    lack    inflammation    creatures    international    thoroughly    nanoscope    spatial    dimensional    artefacts    microstructure    life    diseases    function    complemented    vascular    local    imaging    thereby    due    morphology    transport    ex    animals    subject    monitoring    considerable    productivity    ageing    pis    vivo    mice    time    learning    serial    treatment    impaired    living    small    acquisition    datasets    twitching    speed    occurrence    4d    ing    resolved    chemical    hormones    collaborators    dimensions    image    disease    images    bone    consequent    series    society    precision    dynamics    vitro   

Project "4-D nanoSCOPE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM ERLANGEN 

Organization address
address: MAXIMILIANSPLATZ 2
city: ERLANGEN
postcode: 91054
website: www.uk-erlangen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 12˙366˙635 €
 EC max contribution 12˙366˙635 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM ERLANGEN DE (ERLANGEN) coordinator 2˙837˙980.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 6˙773˙605.00
3    FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG DE (ERLANGEN) participant 2˙755˙050.00
4    HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH DE (BERLIN) participant 0.00

Map

 Project objective

Due to Europe's ageing society, there has been a dramatic increase in the occurrence of osteoporosis (OP) and related diseases. Sufferers have an impaired quality of life, and there is a considerable cost to society associated with the consequent loss of productivity and injuries. The current understanding of this disease needs to be revolutionized, but study has been hampered by a lack of means to properly characterize bone structure, remodeling dynamics and vascular activity. This project, 4D nanoSCOPE, will develop tools and techniques to permit time-resolved imaging and characterization of bone in three spatial dimensions (both in vitro and in vivo), thereby permitting monitoring of bone remodeling and revolutionizing the understanding of bone morphology and its function. To advance the field, in vivo high-resolution studies of living bone are essential, but existing techniques are not capable of this. By combining state-of-the art image processing software with innovative 'precision learning' software methods to compensate for artefacts (due e.g. to the subject breathing or twitching), and innovative X-ray microscope hardware which together will greatly speed up image acquisition (aim is a factor of 100), the project will enable in vivo X-ray microscopy studies of small animals (mice) for the first time. The time series of three-dimensional X-ray images will be complemented by correlative microscopy and spectroscopy techniques (with new software) to thoroughly characterize (serial) bone sections ex vivo. The resulting three-dimensional datasets combining structure, chemical composition, transport velocities and local strength will be used by the PIs and international collaborators to study the dynamics of bone microstructure. This will be the first time that this has been possible in living creatures, enabling an assessment of the effects on bone of age, hormones, inflammation and treatment.

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The information about "4-D NANOSCOPE" are provided by the European Opendata Portal: CORDIS opendata.

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