Explore the words cloud of the RecoverInFlame project. It provides you a very rough idea of what is the project "RecoverInFlame" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||1˙487˙500 €|
|EC max contribution||1˙487˙500 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-11-01 to 2023-10-31|
Take a look of project's partnership.
|1||LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN||DE (MUENCHEN)||coordinator||1˙487˙500.00|
The overall goal of this project is to investigate T cells as “Trojan horses” to improve recovery from brain injuries – we will gain novel insights on how T cells promote neurologic recovery by modulating the cerebral micromilieu and how these pathomechanisms can be therapeutically targeted. Inflammation is a common response to acute brain injuries, which are a leading cause of morbidity and mortality. I have recently identified continuous cerebral T cell recruitment as a hallmark of a long-lasting and profound neuroinflammation after acute brain injury. While a detrimental effect of T cells in the acute phase has been well documented, the pathophysiological consequences and therapeutic potential of T cell-driven chronic inflammation for recovery after brain injury are unknown. Interestingly, my recent findings indicate that T cell fate is orchestrated in the gut via modulation of commensal bacteria and that T cells potently promote stroke recovery. Building up on these recent findings, I hypothesize that T cells contribute substantially to the recovery after brain injury by inflammation-driven remodeling. Using several innovative methodologies applied for the first time to recovery after brain injury, we will firstly investigate the contribution of T cells on cortical connectivity, spine plasticity and mechanisms of glial responses. Next, we will analyze the contribution of the gut microbiota to modulate the chronic neuroinflammatory response via a pro-regenerative polarization of T helper cells. Finally, we will test the generalizability and translational robustness of our findings in models of various acute brain injuries and common comorbidities. Results from this project are likely to open up a new research field on T cell-driven neurologic recovery after brain injury, thereby revolutionizing our pathomechanistic understanding and provide novel therapeutic strategies for one of the most pressing medical problems.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RECOVERINFLAME" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "RECOVERINFLAME" are provided by the European Opendata Portal: CORDIS opendata.
Discovering a novel allergen immunotherapy in house dust mite allergy tolerance researchRead More
Just because we can, should we? An anthropological perspective on the initiation of technology dependence to sustain a child’s lifeRead More
Translating the Global Refined Analysis of Newly transcribed RNA and Decay rates by SLAM-seqRead More