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Intra-tumoral heterogeneity in NRAS-driven metastatic melanoma

Total Cost €


EC-Contrib. €






 INHuMAN project word cloud

Explore the words cloud of the INHuMAN project. It provides you a very rough idea of what is the project "INHuMAN" about.

diverse    tools    longitudinal    trajectories    migrate    diagnostics    therapy    drive    combination    framework    environment    intermediate    integrating    phenotypic    mechanisms    inference    deaths    incomplete    transcriptome    molecular    invade    cell    propensity    underlying    barrier    events    gene    magnitude    largely    exhaustive    dynamics    metastasis    drivers    capture    therapeutics    lineage    reprogramming    melanoma    simultaneous    interception    resolution    therapeutic    diversity    encounter    detection    disease    vasate    omics    4d    host    genetic    varying    fate    clinically    space    regulatory    refractory    mouse    prognostic    networks    deciphered    view    provides    initiation    metastatic    rational    modalities    data    genome    exploited    lab    trajectory    patients    90    cellular    powerful    epigenome    analytical    adapt    actively    cancer    single    transitions    avenues    profiling    switching    extra    perform    origin    acquire    portray    reversible    tracing    model    responsible    thereby    amenable    stress    time    advent    cells   

Project "INHuMAN" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 166˙320.00


 Project objective

Metastasis is largely refractory to therapy and, thereby, responsible for 90% of cancer-related deaths. An incomplete view of the mechanisms that drive metastasis has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for metastatic patients. There is increasing evidence that this multi-step process involves reversible non-genetic reprogramming events allowing cancer cells to acquire diverse phenotypic features needed to migrate, invade, intra/extra-vasate and actively adapt to the varying environment (stress) they encounter. Understanding metastasis therefore requires methodologies that capture the magnitude and dynamics of non-genetic reprogramming in 4D (space and time) at the single-cell resolution. The advent of reliable single-cell multi-Omics analytical tools allows the simultaneous profiling of single cell’s genome, epigenome and transcriptome. Integrating single-cell profiling with lineage tracing provides a robust framework for defining cell fate transitions, intermediate states and trajectory inference. The host lab has recently used such a powerful combination of approaches to study the cellular origin of melanoma, the early molecular events associated with initiation of the disease and to portray cell state dynamics during therapy response. I propose to exploit this know-how to perform a longitudinal and exhaustive analysis of the diversity and trajectories of melanoma cell states during metastatic dissemination using a clinically-relevant mouse model of melanoma, a disease with a very high metastatic propensity. The gene regulatory networks underlying the identified metastatic cell states will be deciphered and the data exploited to develop therapeutic modalities targeting (amenable) drivers of state switching that contribute to early key steps of the metastatic process. The project is expected to lead to new avenues for early detection and interception of metastatic melanoma.

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The information about "INHUMAN" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2020-11-26 21:04:03) correctly updated