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INHuMAN SIGNED

Intra-tumoral heterogeneity in NRAS-driven metastatic melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INHuMAN project word cloud

Explore the words cloud of the INHuMAN project. It provides you a very rough idea of what is the project "INHuMAN" about.

actively    transitions    drivers    transcriptome    trajectories    lab    thereby    regulatory    perform    varying    networks    switching    single    longitudinal    reversible    disease    exhaustive    portray    propensity    powerful    underlying    invade    rational    vasate    modalities    90    fate    acquire    diagnostics    melanoma    deaths    adapt    space    therapeutics    lineage    diversity    initiation    provides    therapy    diverse    cells    profiling    4d    trajectory    environment    origin    model    magnitude    metastasis    analytical    clinically    epigenome    avenues    host    genetic    inference    gene    genome    metastatic    encounter    tracing    integrating    cellular    cell    responsible    mouse    framework    capture    largely    refractory    patients    prognostic    data    mechanisms    barrier    dynamics    exploited    interception    therapeutic    extra    incomplete    simultaneous    view    migrate    omics    intermediate    molecular    phenotypic    detection    drive    combination    events    deciphered    advent    resolution    amenable    reprogramming    time    cancer    stress    tools   

Project "INHuMAN" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 166˙320.00

Map

 Project objective

Metastasis is largely refractory to therapy and, thereby, responsible for 90% of cancer-related deaths. An incomplete view of the mechanisms that drive metastasis has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for metastatic patients. There is increasing evidence that this multi-step process involves reversible non-genetic reprogramming events allowing cancer cells to acquire diverse phenotypic features needed to migrate, invade, intra/extra-vasate and actively adapt to the varying environment (stress) they encounter. Understanding metastasis therefore requires methodologies that capture the magnitude and dynamics of non-genetic reprogramming in 4D (space and time) at the single-cell resolution. The advent of reliable single-cell multi-Omics analytical tools allows the simultaneous profiling of single cell’s genome, epigenome and transcriptome. Integrating single-cell profiling with lineage tracing provides a robust framework for defining cell fate transitions, intermediate states and trajectory inference. The host lab has recently used such a powerful combination of approaches to study the cellular origin of melanoma, the early molecular events associated with initiation of the disease and to portray cell state dynamics during therapy response. I propose to exploit this know-how to perform a longitudinal and exhaustive analysis of the diversity and trajectories of melanoma cell states during metastatic dissemination using a clinically-relevant mouse model of melanoma, a disease with a very high metastatic propensity. The gene regulatory networks underlying the identified metastatic cell states will be deciphered and the data exploited to develop therapeutic modalities targeting (amenable) drivers of state switching that contribute to early key steps of the metastatic process. The project is expected to lead to new avenues for early detection and interception of metastatic melanoma.

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The information about "INHUMAN" are provided by the European Opendata Portal: CORDIS opendata.

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