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PCinBC SIGNED

Plasma cell heterogeneity and dynamics in patient tumors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PCinBC project word cloud

Explore the words cloud of the PCinBC project. It provides you a very rough idea of what is the project "PCinBC" about.

plasma    biology    besides    microenvironment    functions    cancer    combination    reservoir    relative    cell    spatial    untapped    age    humans    vantage    anticancer    treat    unable    first    survival    exchange    tumors    therapy    predict    care    histological    mapped    decade    home    skillsets    limited    single    turnover    types    during    infiltrate    producing    replaced    transcriptomics    patient    feasibility    fundamental    stroma    uncover    frequently    fold    clarify    rna    avenues    questions    expression    last    mainly    dating    performing    fail    coupled    solid    human    immune    uniquely    host    regarding    infiltrating    knowing    revolutionized    carbon    mechanisms    generate    lab    pc    interactome    antibody    patients    receptor    associates    cells    positive    therapeutic    latter    prognosis    cellular    immunotherapies    seq    points    tissue    tumor    lifespan    breast    immunology    opportunity    heterogeneity    accurately   

Project "PCinBC" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 203˙852 €
 EC max contribution 203˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 203˙852.00

Map

 Project objective

During the last decade, the ability to treat cancer by targeting the immune system has revolutionized cancer care, but many patients still fail to respond to current immunotherapies, which mainly target T cells. Besides T cells, the tumor microenvironment is home to many other immune cells; however, we are still unable to accurately predict and target the functions of most tumor-infiltrating immune cells, particularly in human cancer. These cells and their tumor-associated functions represent an untapped reservoir of therapeutic targets. Plasma cells (PC), which are antibody-producing cells derived from B cells, frequently infiltrate solid tumors and their presence associates with positive prognosis across cancer types; yet, our knowledge of tumor-infiltrating PC remains limited. The goal of this project is two-fold: first, I aim to use single cell RNA-seq coupled with spatial transcriptomics (developed by the host lab) to define the heterogeneity and spatial distribution of PC (and their subsets) relative to other cells/histological features in patient breast tumors. PC receptor expression and survival factors will be mapped to generate a PC-tumor stroma 'interactome', which should facilitate defining potential vantage points for therapy. Second, I aim to define the cellular age of tumor-infiltrating PC, since knowing how cells are replaced in a tissue could be highly relevant to both uncover fundamental cell turnover mechanisms and to define new therapeutic avenues. The combination of skillsets between the applicant (tumor immunology) and the host lab (spatial transcriptomics and carbon dating, the latter which uniquely can be used to determine cellular lifespan in humans) presents a unique opportunity for the feasibility and knowledge exchange involved in performing this work. This study’s results could help clarify fundamental questions regarding the biology of tumor-infiltrating plasma cells and help uncover novel anticancer therapeutic targets.

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The information about "PCINBC" are provided by the European Opendata Portal: CORDIS opendata.

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