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PCinBC SIGNED

Plasma cell heterogeneity and dynamics in patient tumors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PCinBC project word cloud

Explore the words cloud of the PCinBC project. It provides you a very rough idea of what is the project "PCinBC" about.

knowing    pc    clarify    cell    tumors    host    frequently    cellular    during    antibody    survival    uncover    mechanisms    questions    treat    therapy    care    heterogeneity    reservoir    dating    lab    avenues    predict    age    humans    fail    accurately    microenvironment    revolutionized    uniquely    first    besides    producing    prognosis    turnover    cancer    exchange    combination    functions    seq    lifespan    infiltrate    mapped    home    breast    points    immunotherapies    limited    replaced    immunology    coupled    single    skillsets    interactome    untapped    rna    receptor    tissue    spatial    histological    decade    expression    therapeutic    immune    biology    anticancer    regarding    patients    generate    cells    solid    types    relative    latter    performing    unable    plasma    fold    human    opportunity    carbon    mainly    patient    last    infiltrating    vantage    feasibility    associates    stroma    tumor    positive    fundamental    transcriptomics   

Project "PCinBC" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 203˙852 €
 EC max contribution 203˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 203˙852.00

Map

 Project objective

During the last decade, the ability to treat cancer by targeting the immune system has revolutionized cancer care, but many patients still fail to respond to current immunotherapies, which mainly target T cells. Besides T cells, the tumor microenvironment is home to many other immune cells; however, we are still unable to accurately predict and target the functions of most tumor-infiltrating immune cells, particularly in human cancer. These cells and their tumor-associated functions represent an untapped reservoir of therapeutic targets. Plasma cells (PC), which are antibody-producing cells derived from B cells, frequently infiltrate solid tumors and their presence associates with positive prognosis across cancer types; yet, our knowledge of tumor-infiltrating PC remains limited. The goal of this project is two-fold: first, I aim to use single cell RNA-seq coupled with spatial transcriptomics (developed by the host lab) to define the heterogeneity and spatial distribution of PC (and their subsets) relative to other cells/histological features in patient breast tumors. PC receptor expression and survival factors will be mapped to generate a PC-tumor stroma 'interactome', which should facilitate defining potential vantage points for therapy. Second, I aim to define the cellular age of tumor-infiltrating PC, since knowing how cells are replaced in a tissue could be highly relevant to both uncover fundamental cell turnover mechanisms and to define new therapeutic avenues. The combination of skillsets between the applicant (tumor immunology) and the host lab (spatial transcriptomics and carbon dating, the latter which uniquely can be used to determine cellular lifespan in humans) presents a unique opportunity for the feasibility and knowledge exchange involved in performing this work. This study’s results could help clarify fundamental questions regarding the biology of tumor-infiltrating plasma cells and help uncover novel anticancer therapeutic targets.

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The information about "PCINBC" are provided by the European Opendata Portal: CORDIS opendata.

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