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PCinBC SIGNED

Plasma cell heterogeneity and dynamics in patient tumors

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PCinBC project word cloud

Explore the words cloud of the PCinBC project. It provides you a very rough idea of what is the project "PCinBC" about.

functions    uncover    types    clarify    receptor    last    therapeutic    single    antibody    stroma    frequently    expression    host    mapped    decade    first    feasibility    positive    interactome    accurately    skillsets    opportunity    home    regarding    transcriptomics    seq    relative    reservoir    cells    infiltrate    microenvironment    cellular    prognosis    human    avenues    cancer    questions    treat    generate    knowing    besides    therapy    mainly    spatial    limited    immunology    cell    immunotherapies    exchange    lab    turnover    pc    associates    untapped    plasma    lifespan    patients    uniquely    heterogeneity    solid    during    predict    revolutionized    fundamental    infiltrating    immune    age    biology    fail    humans    carbon    patient    care    anticancer    latter    points    histological    tumors    rna    fold    producing    unable    replaced    mechanisms    coupled    tumor    vantage    dating    survival    combination    breast    tissue    performing   

Project "PCinBC" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 203˙852 €
 EC max contribution 203˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 203˙852.00

Map

 Project objective

During the last decade, the ability to treat cancer by targeting the immune system has revolutionized cancer care, but many patients still fail to respond to current immunotherapies, which mainly target T cells. Besides T cells, the tumor microenvironment is home to many other immune cells; however, we are still unable to accurately predict and target the functions of most tumor-infiltrating immune cells, particularly in human cancer. These cells and their tumor-associated functions represent an untapped reservoir of therapeutic targets. Plasma cells (PC), which are antibody-producing cells derived from B cells, frequently infiltrate solid tumors and their presence associates with positive prognosis across cancer types; yet, our knowledge of tumor-infiltrating PC remains limited. The goal of this project is two-fold: first, I aim to use single cell RNA-seq coupled with spatial transcriptomics (developed by the host lab) to define the heterogeneity and spatial distribution of PC (and their subsets) relative to other cells/histological features in patient breast tumors. PC receptor expression and survival factors will be mapped to generate a PC-tumor stroma 'interactome', which should facilitate defining potential vantage points for therapy. Second, I aim to define the cellular age of tumor-infiltrating PC, since knowing how cells are replaced in a tissue could be highly relevant to both uncover fundamental cell turnover mechanisms and to define new therapeutic avenues. The combination of skillsets between the applicant (tumor immunology) and the host lab (spatial transcriptomics and carbon dating, the latter which uniquely can be used to determine cellular lifespan in humans) presents a unique opportunity for the feasibility and knowledge exchange involved in performing this work. This study’s results could help clarify fundamental questions regarding the biology of tumor-infiltrating plasma cells and help uncover novel anticancer therapeutic targets.

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The information about "PCINBC" are provided by the European Opendata Portal: CORDIS opendata.

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