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SAECG SIGNED

Prediction of AF incidence using PR interval measurements, echocardiographic data and biomarker profiles: Analyses within epidemiological Framingham Heart Study and LIFE Health Care Study cohorts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SAECG project word cloud

Explore the words cloud of the SAECG project. It provides you a very rough idea of what is the project "SAECG" about.

laboratory    leads    electrocardiogram    issue    composite    predicting    activation    epidemic    echocardiography    outcomes    phenomapping    boston    saecg    practical    cardiovascular    risk    wave    af    limited    accurately    paves    germany    atrial    fruitful    signal    fibrillation    describe    researcher    cooperation    classification    clinical    thromboembolism    leipzig    sapwd    tools    prolonged    health    underlying    dementia    modeling    performed    saecgs    marker    broad    mobility    multiple    renowned    international    standard    pathological    diagnostical    lifetime    categorized    intensive    invasive    demonstrating    authentic    superior    associations    innovative    heart    incidence    cohort    disease    remodeling    measured    averaged    12    ecg    orthogonal    multidisciplinary    estimation    filtered    cardiac    corresponding    easiest    prevention    biomarkers    perspectives    prolongation    detection    multistate    indices    epidemiology    times    care    mechanisms    life    epidemiological    patients    exchange    adverse    analyzing    perform    vector    framingham    academical    data    mortality   

Project "SAECG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET LEIPZIG 

Organization address
address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109
website: www.uni-Ieipzig.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET LEIPZIG DE (LEIPZIG) coordinator 264˙669.00
2    THE TRUSTEES OF BOSTON UNIVERSITY US (BOSTON MA) partner 0.00

Map

 Project objective

Atrial fibrillation (AF) may be categorized as an epidemic disease associated with an increased risk for heart failure, thromboembolism, dementia and mortality. The underlying mechanisms behind AF describe multiple pathological states leading to various remodeling processes. One of the easiest available diagnostical tools is an electrocardiogram (ECG). Numerous P wave indices have been identified, demonstrating associations with increased risk for adverse cardiovascular outcomes and mortality. Prolonged signal-averaged P wave duration (SAPWD) measured from the non-invasive signal averaged electrocardiogram (SAECG) using a vector composite of filtered orthogonal leads accurately measures cardiac activation times. In comparison with analysis of a standard 12-lead ECG, the SAECG is superior in detection of P wave prolongation as a risk marker for AF. However, there are only limited data analyzing this issue. Current project is aimed to perform P wave SAECGs in Framingham Heart Study (Boston, US) and LIFE Health Care Study (Leipzig, Germany) and to investigate their role in AF incidence. Furthermore, estimation of corresponding lifetime risk will be performed using multistate modeling phenomapping of AF, e.g. classification of AF patients based on a broad range of data (clinical, laboratory, ECG, echocardiography, biomarkers) predicting adverse clinical outcomes. The current project represents an innovative and authentic multidisciplinary research in AF and includes different future perspectives. It paves the way for fruitful international cooperation with Framingham cohort - the one the most renowned epidemiological studies, intensive exchange of experience and researcher mobility as well as academical and practical implementation of cardiovascular epidemiology and prevention at European institution.

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