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SAECG SIGNED

Prediction of AF incidence using PR interval measurements, echocardiographic data and biomarker profiles: Analyses within epidemiological Framingham Heart Study and LIFE Health Care Study cohorts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 SAECG project word cloud

Explore the words cloud of the SAECG project. It provides you a very rough idea of what is the project "SAECG" about.

pathological    demonstrating    saecg    easiest    prolongation    international    disease    categorized    performed    issue    times    dementia    authentic    wave    predicting    underlying    mechanisms    classification    orthogonal    incidence    marker    cooperation    corresponding    echocardiography    intensive    af    practical    composite    care    associations    researcher    broad    boston    laboratory    fruitful    cardiac    leads    innovative    indices    outcomes    measured    epidemic    thromboembolism    accurately    perform    signal    describe    tools    paves    ecg    multistate    adverse    life    data    risk    academical    perspectives    sapwd    framingham    biomarkers    mortality    renowned    saecgs    atrial    electrocardiogram    activation    health    analyzing    estimation    averaged    fibrillation    vector    modeling    multiple    epidemiology    leipzig    heart    12    patients    superior    prolonged    mobility    cardiovascular    filtered    diagnostical    exchange    epidemiological    invasive    clinical    standard    detection    multidisciplinary    phenomapping    germany    prevention    cohort    remodeling    limited    lifetime   

Project "SAECG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET LEIPZIG 

Organization address
address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109
website: www.uni-Ieipzig.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET LEIPZIG DE (LEIPZIG) coordinator 264˙669.00
2    THE TRUSTEES OF BOSTON UNIVERSITY US (BOSTON MA) partner 0.00

Map

 Project objective

Atrial fibrillation (AF) may be categorized as an epidemic disease associated with an increased risk for heart failure, thromboembolism, dementia and mortality. The underlying mechanisms behind AF describe multiple pathological states leading to various remodeling processes. One of the easiest available diagnostical tools is an electrocardiogram (ECG). Numerous P wave indices have been identified, demonstrating associations with increased risk for adverse cardiovascular outcomes and mortality. Prolonged signal-averaged P wave duration (SAPWD) measured from the non-invasive signal averaged electrocardiogram (SAECG) using a vector composite of filtered orthogonal leads accurately measures cardiac activation times. In comparison with analysis of a standard 12-lead ECG, the SAECG is superior in detection of P wave prolongation as a risk marker for AF. However, there are only limited data analyzing this issue. Current project is aimed to perform P wave SAECGs in Framingham Heart Study (Boston, US) and LIFE Health Care Study (Leipzig, Germany) and to investigate their role in AF incidence. Furthermore, estimation of corresponding lifetime risk will be performed using multistate modeling phenomapping of AF, e.g. classification of AF patients based on a broad range of data (clinical, laboratory, ECG, echocardiography, biomarkers) predicting adverse clinical outcomes. The current project represents an innovative and authentic multidisciplinary research in AF and includes different future perspectives. It paves the way for fruitful international cooperation with Framingham cohort - the one the most renowned epidemiological studies, intensive exchange of experience and researcher mobility as well as academical and practical implementation of cardiovascular epidemiology and prevention at European institution.

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