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SAECG SIGNED

Prediction of AF incidence using PR interval measurements, echocardiographic data and biomarker profiles: Analyses within epidemiological Framingham Heart Study and LIFE Health Care Study cohorts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 SAECG project word cloud

Explore the words cloud of the SAECG project. It provides you a very rough idea of what is the project "SAECG" about.

risk    epidemiology    germany    performed    international    modeling    phenomapping    fibrillation    accurately    health    prolonged    innovative    perspectives    superior    leipzig    practical    mechanisms    echocardiography    laboratory    invasive    saecg    marker    lifetime    intensive    cardiac    heart    remodeling    electrocardiogram    activation    framingham    multiple    analyzing    multistate    incidence    patients    researcher    life    underlying    multidisciplinary    ecg    orthogonal    wave    cooperation    classification    prolongation    pathological    mortality    predicting    epidemiological    broad    exchange    leads    care    easiest    indices    prevention    sapwd    dementia    demonstrating    measured    mobility    signal    tools    disease    paves    diagnostical    describe    af    times    estimation    detection    atrial    academical    outcomes    cardiovascular    12    epidemic    clinical    thromboembolism    corresponding    filtered    fruitful    adverse    associations    renowned    limited    categorized    perform    biomarkers    authentic    standard    composite    vector    cohort    saecgs    data    boston    issue    averaged   

Project "SAECG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET LEIPZIG 

Organization address
address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109
website: www.uni-Ieipzig.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET LEIPZIG DE (LEIPZIG) coordinator 264˙669.00
2    THE TRUSTEES OF BOSTON UNIVERSITY US (BOSTON MA) partner 0.00

Map

 Project objective

Atrial fibrillation (AF) may be categorized as an epidemic disease associated with an increased risk for heart failure, thromboembolism, dementia and mortality. The underlying mechanisms behind AF describe multiple pathological states leading to various remodeling processes. One of the easiest available diagnostical tools is an electrocardiogram (ECG). Numerous P wave indices have been identified, demonstrating associations with increased risk for adverse cardiovascular outcomes and mortality. Prolonged signal-averaged P wave duration (SAPWD) measured from the non-invasive signal averaged electrocardiogram (SAECG) using a vector composite of filtered orthogonal leads accurately measures cardiac activation times. In comparison with analysis of a standard 12-lead ECG, the SAECG is superior in detection of P wave prolongation as a risk marker for AF. However, there are only limited data analyzing this issue. Current project is aimed to perform P wave SAECGs in Framingham Heart Study (Boston, US) and LIFE Health Care Study (Leipzig, Germany) and to investigate their role in AF incidence. Furthermore, estimation of corresponding lifetime risk will be performed using multistate modeling phenomapping of AF, e.g. classification of AF patients based on a broad range of data (clinical, laboratory, ECG, echocardiography, biomarkers) predicting adverse clinical outcomes. The current project represents an innovative and authentic multidisciplinary research in AF and includes different future perspectives. It paves the way for fruitful international cooperation with Framingham cohort - the one the most renowned epidemiological studies, intensive exchange of experience and researcher mobility as well as academical and practical implementation of cardiovascular epidemiology and prevention at European institution.

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