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miRhythm SIGNED

Understanding mechanisms and functions of miRNA oscillations during development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 miRhythm project word cloud

Explore the words cloud of the miRhythm project. It provides you a very rough idea of what is the project "miRhythm" about.

precise    biological    elegans    successful    host    orchestration    metabolism    rely    temporal    bioinformatics    exhibit    mostly    enigmatic    progression    shedding    oscillation    mechanisms    render    relies    events    repetitive    paradigm    gene    tracking    expression    additional    amplitudes    timers    cuticle    period    sufficiently    developmental    orchestrate    regulatory    single    remained    transcription    function    small    differentiation    appear    throughput    stable    encompassing    lab    exactly    rhythmic    generally    synthesis    uncover    careful    2700    mirnas    organism    timing    mirna    delineate    proliferation    experimental    oscillations    sequencing    hr    molecular    largely    transcript    unstable    amplitude    fundamental    larval    oscillatory    of    diverse    genetic    cell    assets    surprising    periodic    reproducibility    uncovered    once    peaking    genes    organismal    biophysics    quite    stage    tractability    principles    nematode    migration    combination      

Project "miRhythm" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 203˙149.00

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 Project objective

Successful development of an organism relies on careful temporal orchestration of a large number of diverse events. Although processes such as cell proliferation, migration and differentiation are thus under precise temporal control, molecular mechanisms of the relevant biological timers have remained largely enigmatic. I propose to exploit the repetitive development and robust oscillatory gene expression of the nematode C. elegans to identify fundamental principles of temporal control of organismal development through rhythmic gene expression. High temporal reproducibility of developmental progression and genetic tractability are additional major assets of this novel experimental paradigm. Previous work in my host-lab uncovered high-amplitude oscillatory expression of ~2700 genes peaking exactly once per larval stage, with an ~8-hr period. These oscillations appear to orchestrate periodic developmental events encompassing synthesis and shedding of the cuticle, cell proliferation and differentiation. A small set of regulatory miRNAs also exhibit oscillations with large amplitudes. This is surprising given that miRNAs are generally quite stable, and that the transcript level oscillations appear to be rely mostly on rhythmic transcription. Here, I propose to delineate the function of oscillatory miRNAs in rhythmic gene expression and development, and the mechanisms that render them sufficiently unstable to facilitate oscillation. Thus, through a combination of high-throughput developmental tracking, single-cell sequencing, bioinformatics, and biophysics approaches, I expect to uncover molecular mechanisms that control developmental timing and miRNA metabolism.

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The information about "MIRHYTHM" are provided by the European Opendata Portal: CORDIS opendata.

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