Explore the words cloud of the FEN INHIBITORS project. It provides you a very rough idea of what is the project "FEN INHIBITORS" about.
The following table provides information about the project.
THE UNIVERSITY OF SHEFFIELD
|Coordinator Country||United Kingdom [UK]|
|Total cost||319˙400 €|
|EC max contribution||319˙400 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2020-02-01 to 2023-01-31|
Take a look of project's partnership.
|1||THE UNIVERSITY OF SHEFFIELD||UK (SHEFFIELD)||coordinator||319˙400.00|
We are searching for Kinetoplastida flap endonuclease (FEN) inhibitors as a base for potential therapeutics for parasite infections, for which there is significant unmet clinical need. Kinetoplastida are flagellated protists responsible for 3 neglected human diseases. We will target the FEN enzymes from Trypanasoma cruzi and Leishmania species, the organisms causing Chagas disease and leishmaniaisis respectively. FEN activity is crucial for the survival of all organisms tested so far from mouse to bacteria, including Trypanosoma. We will identify specific inhibitors of Kinetoplastida FENs as the basis for future development of urgently needed new therapeutics. This multidisciplinary structure-based inhibitor design project will involve in vitro and in silico screening, protein crystallization, rounds of inhibitor design and finally in vivo potency and toxicity experiments. The project will be overseen by Prof Sayers who has 30 years of experience with nucleases and who has founded two spin-out companies. His group is complemented through collaboration with a parasitologist Dr Helen Price (20 years research experience), who has been actively involved in developing antiparasitic agents. The experienced researcher, who has a strong protein biochemistry and crystallography background, is returning to academic research after almost 4 years outside science. Ultimately, the experienced researcher is aspiring to an academic career in translational medicine rooted in state-of-the-art basic research but with the skills and experience to synergise with the pharmaceutical sector.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FEN INHIBITORS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "FEN INHIBITORS" are provided by the European Opendata Portal: CORDIS opendata.
Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. ElegansRead More
Shaping the European Migration Policy: the role of the security industryRead More
The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshesRead More