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NG2-cells SIGNED

The role of NG2 cells in the neural network in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NG2-cells project word cloud

Explore the words cloud of the NG2-cells project. It provides you a very rough idea of what is the project "NG2-cells" about.

population    mechanisms    understand    life    healthy    excitability    modulate    designed    disease    relationship    will    axons    covers    network    multitude    adult    cells    models    retain    postnatal    pathologies    form    nervous    ensheathing    huge    neuronal    sclerosis    details    rendering    multiple    neurodegenerative    morphological    epilepsy    entire    cutting    considering    dysfunction    edge    glia    node    parkinson    oligodendrocyte    regenerative    subpopulation    capacity    combination    altered    white    myelination    function    diseases    regulated    contribution    central    underscores    enhanced    contact    parenchyma    permanent    physiological    density    contacts    therein    functional    myelin    onto    alzheimer    oligodendrocytes    self    unknown    loss    structural    neural    ranvier    renewal    cell    turn    mature    techniques    brain    first    weeks    synaptic    becomes    generate    found    organisms    differentiate    highest    ng2    questions    differentiation    glial    depolarize    grey    vivo    disorders    regulate    neurons   

Project "NG2-cells" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 264˙669 €
 EC max contribution 264˙669 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 264˙669.00
2    UNIVERSITY OF CONNECTICUT US (STORRS) partner 0.00

Map

 Project objective

Loss of myelin and oligodendrocyte dysfunction is being recognized in many neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer's or Parkinson's disease or Epilepsy, although the mechanisms are not yet understood. Oligodendrocytes are generated from NG2 cells, a glial cell population that covers the entire parenchyma of the central nervous system. The multitude of disorders involving oligodendrocyte pathologies in grey and white matter underscores the importance to understand how oligodendrocyte differentiation and myelination are regulated, and the role of NG2 cells therein. The highest density of NG2 cells can be found during the first postnatal weeks, when they differentiate into mature oligodendrocytes ensheathing axons with myelin. NG2 cells retain the capacity for self-renewal throughout life, rendering them a huge regenerative potential in the adult brain. It is still unknown whether all NG2 cells have the same potential to generate oligodendrocytes or whether a subpopulation of them becomes permanent NG2 cells. Neurons form synaptic contacts onto NG2 cells and depolarize them, in order to regulate myelination. Considering the finding, that processes of NG2 glia contact neurons at the node of Ranvier, it could be possible that NG2 cells in turn are able to modulate neuronal activity. To address these questions, this project is designed to investigate how altered neuronal excitability affects the structural and functional relationship between neurons and NG2 cells and how these changes impact the neural network. Using a combination of several cutting-edge techniques, the details of the morphological contact formation as well as the physiological function of these contacts in vivo in models of enhanced neuronal activity will be assessed. The results will be a major contribution to understanding the role of NG2 cells in the neural network in healthy organisms as well as in the numerous diseases where oligodendrocytes are affected.

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The information about "NG2-CELLS" are provided by the European Opendata Portal: CORDIS opendata.

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