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ONCOTECT SIGNED

Early detection of tumor DNA in liquid biopsies as a biomarker of cancer recurrence

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ONCOTECT project word cloud

Explore the words cloud of the ONCOTECT project. It provides you a very rough idea of what is the project "ONCOTECT" about.

ultra    kit    recurrent    clinical    fto    treatment    competing    disrupt    monitoring    sensitive    programs    lesions    market    lower    operate    head    hnc    breaking    inexpensive    assay    quality    patients    routine    regulatory    detection    rates    leveraging    genes    company    spectrum    screening    workflow    time    diagnostics    feasibility    fast    cohort    oncogenic    neck    relative    start    vision    biopsies    sequencing    bv    full    samples    blood    strategy    dna    ground    sme    obtain    proof    cyclomics    critical    standard    encompassing    underlying    opportunity    accurate    delays    detect    commercialization    licensing    oncotect    freedom    cancer    decision    death    radiological    unable    considerable    ambition    diagnostic    ct    superior    disease    vitro    gene    tp53    remission    90    initial    liquid    faster    methodology    proprietary    circulating    dutch    types    ivd    reliably    recurrence    carry    survival    detects    integration    tumor    detecting    first    care    mutations    examination   

Project "ONCOTECT" data sheet

The following table provides information about the project.

Coordinator		 CYCLOMICS BV 

Organization address
address: MOSKEEPLEIN 82
city: UTRECHT
postcode: 3531 BX
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Netherlands [NL]
 Project website https://www.cyclomics.com/technology.html
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CYCLOMICS BV NL (UTRECHT) coordinator 50˙000.00

Map

 Project objective

Cyclomics BV is a Dutch start-up company with the ambition to disrupt the cancer diagnostics market with its proprietary circulating tumor (ct) DNA detection technology. Cyclomics has developed a ground-breaking sequencing methodology that enables reliable, fast and ultra-sensitive detection of cancer recurrence from blood samples (liquid biopsies). The first product, ONCOTECT, detects oncogenic mutations in the TP53 gene, and is developed for accurate and early detection of head and neck cancer (HNC) recurrence. Recurrent disease after initial remission is a main cause of cancer-related death. In HNC, radiological examination is the current standard in detecting cancer lesions but is unable to reliably detect recurrence early on, leading to treatment delays and lower survival rates. Integration of the ONCOTECT assay into routine clinical workflow is inexpensive and will provide faster time-to-results relative to competing sequencing methods. Since 90% of HNC patients carry specific oncogenic DNA mutations in the TP53 gene, the first application of this novel technology in recurrent HNC presents a considerable market opportunity for ONCOTECT. After achieving clinical proof-of-concept in a cohort of 20 patients, Cyclomics will offer its technology for licensing to a diagnostics company to further develop ONCOTECT as an in vitro diagnostic (IVD) kit and bring it to the market, with the aim of enabling superior quality in diagnostic and clinical decision making. ONCOTECT focuses on TP53 but the underlying technology can be applied to many different genes. Leveraging this potential, Cyclomics’ long-term vision includes monitoring of cancer treatment response and early screening programs, encompassing various genes and cancer types, with the potential to impact the full spectrum of cancer care. In this SME feasibility study, Cyclomics will obtain critical insight for commercialization strategy, including freedom to operate (FTO), user needs and regulatory requirements.

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The information about "ONCOTECT" are provided by the European Opendata Portal: CORDIS opendata.

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