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NANOCELL SIGNED

A DNA NANOtechology toolkit for artificial CELL design

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOCELL project word cloud

Explore the words cloud of the NANOCELL project. It provides you a very rough idea of what is the project "NANOCELL" about.

frameworks    class    behaviours    full    cargoes    library    micron    smart    utilises    membrane    biology    assemble    collective    programmable    therapeutics    organelles    assembly    cellular    bilayer    wp2    encapsulation    consist    wp3    mimic    environmental    capture    patterning    cell    functionalities    emergence    spatiotemporal    afforded    artificially    reflecting    amplification    detection    ultimately    life    nanostructures    unprecedented    platform    compartmentalised    wp1    artificial    unlock    bottom    blocks    synthetic    stimuli    programmability    structural    dynamic    dna    cells    release    signal    compartments    awaited    borrowed    ideal    truly    self    nanotechnology    encapsulating    mapping    biosensing    spanning    replicate    machinery    fashion    biological    nanostructured    objects    amphiphilic    interaction    construction    embedding    modular    nanocell    building    perform    displaying    morphology    structure    relying    packages    remote    ab    poorly    multicellular    hierarchical    prescribe    lipid    chemical    communication    initio    struggles    nanoscale   

Project "NANOCELL" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙497˙477 €
 EC max contribution 1˙497˙477 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙497˙477.00

Map

 Project objective

Bottom-up synthetic biology aims to artificially replicate the emerging behaviours of cellular life but struggles to do so without relying on poorly controllable machinery borrowed from biological cells. DNA nanotechnology enables ab-initio design of nanoscale objects with fully programmable structure and dynamic response, making them ideal to mimic the complex functionalities of biological machinery in a truly bottom-up fashion.

NANOCELL will establish a fully modular and integrated platform that utilises DNA nanotechnology to prescribe structure and functionality of artificial cells.

I will design a library of micron-scale DNA-based objects that mimic cell organelles in their ability to perform specific tasks in response to chemical and environmental stimuli including signal detection and amplification, the capture and release of cargoes, and the construction of structural elements. These “membrane-less organelles” will self-assemble from a new class of amphiphilic DNA building blocks I recently introduced, which enable unprecedented control over the morphology and response of nanostructured frameworks. Interaction between organelles will lead to the emergence of collective effects, and their encapsulation in lipid-bilayer compartments will enable the modular construction of artificial cells displaying a range of complex behaviours such as remote communication, dynamic adaptation, and spatiotemporal patterning in multicellular systems.

NANOCELL will consist of three Work Packages reflecting its hierarchical approach: WP1: Mapping the self-assembly behaviour of amphiphilic DNA nanostructures. WP2: Embedding different functionalities in amphiphilic DNA frameworks to produce artificial organelles. WP3: Creating artificial cells by encapsulating DNA organelles in compartmentalised systems.

The full programmability afforded by NANOCELL will ultimately unlock long-awaited applications of artificial cells, spanning from biosensing to smart therapeutics.

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The information about "NANOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-05-18 4:02:01) correctly updated