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NANOCELL SIGNED

A DNA NANOtechology toolkit for artificial CELL design

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOCELL project word cloud

Explore the words cloud of the NANOCELL project. It provides you a very rough idea of what is the project "NANOCELL" about.

wp3    structure    release    utilises    multicellular    detection    library    nanostructures    objects    struggles    nanocell    smart    full    reflecting    wp2    patterning    capture    communication    functionalities    amplification    replicate    unlock    unprecedented    membrane    packages    cellular    collective    construction    compartments    programmability    embedding    nanotechnology    consist    morphology    compartmentalised    organelles    ideal    encapsulation    biology    bilayer    building    ab    perform    encapsulating    dynamic    structural    stimuli    afforded    displaying    micron    remote    poorly    borrowed    fashion    artificial    cells    initio    biological    machinery    bottom    therapeutics    life    cargoes    modular    dna    spanning    blocks    artificially    programmable    nanoscale    self    class    cell    biosensing    synthetic    prescribe    lipid    interaction    behaviours    hierarchical    frameworks    nanostructured    signal    emergence    chemical    assemble    truly    awaited    platform    relying    environmental    ultimately    mapping    wp1    mimic    assembly    amphiphilic    spatiotemporal   

Project "NANOCELL" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙497˙477 €
 EC max contribution 1˙497˙477 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙497˙477.00

Map

 Project objective

Bottom-up synthetic biology aims to artificially replicate the emerging behaviours of cellular life but struggles to do so without relying on poorly controllable machinery borrowed from biological cells. DNA nanotechnology enables ab-initio design of nanoscale objects with fully programmable structure and dynamic response, making them ideal to mimic the complex functionalities of biological machinery in a truly bottom-up fashion.

NANOCELL will establish a fully modular and integrated platform that utilises DNA nanotechnology to prescribe structure and functionality of artificial cells.

I will design a library of micron-scale DNA-based objects that mimic cell organelles in their ability to perform specific tasks in response to chemical and environmental stimuli including signal detection and amplification, the capture and release of cargoes, and the construction of structural elements. These “membrane-less organelles” will self-assemble from a new class of amphiphilic DNA building blocks I recently introduced, which enable unprecedented control over the morphology and response of nanostructured frameworks. Interaction between organelles will lead to the emergence of collective effects, and their encapsulation in lipid-bilayer compartments will enable the modular construction of artificial cells displaying a range of complex behaviours such as remote communication, dynamic adaptation, and spatiotemporal patterning in multicellular systems.

NANOCELL will consist of three Work Packages reflecting its hierarchical approach: WP1: Mapping the self-assembly behaviour of amphiphilic DNA nanostructures. WP2: Embedding different functionalities in amphiphilic DNA frameworks to produce artificial organelles. WP3: Creating artificial cells by encapsulating DNA organelles in compartmentalised systems.

The full programmability afforded by NANOCELL will ultimately unlock long-awaited applications of artificial cells, spanning from biosensing to smart therapeutics.

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The information about "NANOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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