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NANOCELL SIGNED

A DNA NANOtechology toolkit for artificial CELL design

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOCELL project word cloud

Explore the words cloud of the NANOCELL project. It provides you a very rough idea of what is the project "NANOCELL" about.

behaviours    functionalities    modular    platform    spatiotemporal    micron    release    nanostructured    nanoscale    machinery    poorly    initio    remote    ultimately    mimic    embedding    smart    life    compartmentalised    class    spanning    amplification    chemical    perform    multicellular    prescribe    ab    communication    signal    mapping    replicate    building    cargoes    wp1    morphology    truly    dynamic    artificially    organelles    compartments    ideal    wp2    wp3    patterning    interaction    blocks    dna    assembly    artificial    reflecting    nanostructures    biosensing    encapsulating    detection    packages    cells    displaying    biological    biology    awaited    emergence    self    bottom    environmental    lipid    borrowed    collective    synthetic    encapsulation    stimuli    structural    capture    cell    consist    library    fashion    struggles    hierarchical    bilayer    unlock    frameworks    construction    afforded    programmable    therapeutics    nanotechnology    assemble    objects    unprecedented    structure    relying    programmability    full    nanocell    amphiphilic    membrane    cellular    utilises   

Project "NANOCELL" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙497˙477 €
 EC max contribution 1˙497˙477 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙497˙477.00

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 Project objective

Bottom-up synthetic biology aims to artificially replicate the emerging behaviours of cellular life but struggles to do so without relying on poorly controllable machinery borrowed from biological cells. DNA nanotechnology enables ab-initio design of nanoscale objects with fully programmable structure and dynamic response, making them ideal to mimic the complex functionalities of biological machinery in a truly bottom-up fashion.

NANOCELL will establish a fully modular and integrated platform that utilises DNA nanotechnology to prescribe structure and functionality of artificial cells.

I will design a library of micron-scale DNA-based objects that mimic cell organelles in their ability to perform specific tasks in response to chemical and environmental stimuli including signal detection and amplification, the capture and release of cargoes, and the construction of structural elements. These “membrane-less organelles” will self-assemble from a new class of amphiphilic DNA building blocks I recently introduced, which enable unprecedented control over the morphology and response of nanostructured frameworks. Interaction between organelles will lead to the emergence of collective effects, and their encapsulation in lipid-bilayer compartments will enable the modular construction of artificial cells displaying a range of complex behaviours such as remote communication, dynamic adaptation, and spatiotemporal patterning in multicellular systems.

NANOCELL will consist of three Work Packages reflecting its hierarchical approach: WP1: Mapping the self-assembly behaviour of amphiphilic DNA nanostructures. WP2: Embedding different functionalities in amphiphilic DNA frameworks to produce artificial organelles. WP3: Creating artificial cells by encapsulating DNA organelles in compartmentalised systems.

The full programmability afforded by NANOCELL will ultimately unlock long-awaited applications of artificial cells, spanning from biosensing to smart therapeutics.

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The information about "NANOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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