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NANOCELL SIGNED

A DNA NANOtechology toolkit for artificial CELL design

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOCELL project word cloud

Explore the words cloud of the NANOCELL project. It provides you a very rough idea of what is the project "NANOCELL" about.

initio    functionalities    wp2    objects    programmable    encapsulating    cells    multicellular    amplification    spanning    utilises    poorly    smart    packages    cargoes    construction    chemical    membrane    signal    cellular    dna    reflecting    embedding    mapping    programmability    building    unprecedented    remote    platform    modular    biosensing    compartments    detection    machinery    mimic    spatiotemporal    morphology    release    stimuli    ideal    biological    lipid    encapsulation    amphiphilic    dynamic    communication    displaying    emergence    nanotechnology    assembly    awaited    environmental    hierarchical    library    behaviours    nanocell    assemble    synthetic    nanostructured    biology    replicate    afforded    borrowed    ultimately    artificial    frameworks    truly    organelles    structure    prescribe    capture    nanoscale    unlock    self    ab    cell    wp1    collective    relying    therapeutics    wp3    struggles    structural    artificially    consist    blocks    bilayer    micron    bottom    life    patterning    nanostructures    perform    fashion    class    compartmentalised    interaction    full   

Project "NANOCELL" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙497˙477 €
 EC max contribution 1˙497˙477 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙497˙477.00

Map

 Project objective

Bottom-up synthetic biology aims to artificially replicate the emerging behaviours of cellular life but struggles to do so without relying on poorly controllable machinery borrowed from biological cells. DNA nanotechnology enables ab-initio design of nanoscale objects with fully programmable structure and dynamic response, making them ideal to mimic the complex functionalities of biological machinery in a truly bottom-up fashion.

NANOCELL will establish a fully modular and integrated platform that utilises DNA nanotechnology to prescribe structure and functionality of artificial cells.

I will design a library of micron-scale DNA-based objects that mimic cell organelles in their ability to perform specific tasks in response to chemical and environmental stimuli including signal detection and amplification, the capture and release of cargoes, and the construction of structural elements. These “membrane-less organelles” will self-assemble from a new class of amphiphilic DNA building blocks I recently introduced, which enable unprecedented control over the morphology and response of nanostructured frameworks. Interaction between organelles will lead to the emergence of collective effects, and their encapsulation in lipid-bilayer compartments will enable the modular construction of artificial cells displaying a range of complex behaviours such as remote communication, dynamic adaptation, and spatiotemporal patterning in multicellular systems.

NANOCELL will consist of three Work Packages reflecting its hierarchical approach: WP1: Mapping the self-assembly behaviour of amphiphilic DNA nanostructures. WP2: Embedding different functionalities in amphiphilic DNA frameworks to produce artificial organelles. WP3: Creating artificial cells by encapsulating DNA organelles in compartmentalised systems.

The full programmability afforded by NANOCELL will ultimately unlock long-awaited applications of artificial cells, spanning from biosensing to smart therapeutics.

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The information about "NANOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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