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NANOCELL SIGNED

A DNA NANOtechology toolkit for artificial CELL design

Total Cost €

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EC-Contrib. €

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Partnership

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 NANOCELL project word cloud

Explore the words cloud of the NANOCELL project. It provides you a very rough idea of what is the project "NANOCELL" about.

poorly    multicellular    organelles    dynamic    amplification    chemical    machinery    functionalities    cells    detection    morphology    biological    construction    signal    structure    remote    compartmentalised    communication    platform    blocks    encapsulation    stimuli    artificial    displaying    smart    hierarchical    membrane    modular    relying    unlock    bottom    dna    emergence    full    nanostructures    awaited    programmability    nanoscale    release    prescribe    truly    embedding    self    unprecedented    fashion    cargoes    wp3    programmable    afforded    frameworks    initio    biosensing    collective    amphiphilic    replicate    behaviours    environmental    class    bilayer    perform    library    borrowed    ideal    artificially    spatiotemporal    spanning    nanotechnology    reflecting    compartments    packages    lipid    cellular    structural    life    building    therapeutics    synthetic    ultimately    consist    mimic    utilises    capture    assembly    nanocell    patterning    assemble    ab    nanostructured    wp1    wp2    mapping    cell    micron    encapsulating    interaction    struggles    objects    biology   

Project "NANOCELL" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙497˙477 €
 EC max contribution 1˙497˙477 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙497˙477.00

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 Project objective

Bottom-up synthetic biology aims to artificially replicate the emerging behaviours of cellular life but struggles to do so without relying on poorly controllable machinery borrowed from biological cells. DNA nanotechnology enables ab-initio design of nanoscale objects with fully programmable structure and dynamic response, making them ideal to mimic the complex functionalities of biological machinery in a truly bottom-up fashion.

NANOCELL will establish a fully modular and integrated platform that utilises DNA nanotechnology to prescribe structure and functionality of artificial cells.

I will design a library of micron-scale DNA-based objects that mimic cell organelles in their ability to perform specific tasks in response to chemical and environmental stimuli including signal detection and amplification, the capture and release of cargoes, and the construction of structural elements. These “membrane-less organelles” will self-assemble from a new class of amphiphilic DNA building blocks I recently introduced, which enable unprecedented control over the morphology and response of nanostructured frameworks. Interaction between organelles will lead to the emergence of collective effects, and their encapsulation in lipid-bilayer compartments will enable the modular construction of artificial cells displaying a range of complex behaviours such as remote communication, dynamic adaptation, and spatiotemporal patterning in multicellular systems.

NANOCELL will consist of three Work Packages reflecting its hierarchical approach: WP1: Mapping the self-assembly behaviour of amphiphilic DNA nanostructures. WP2: Embedding different functionalities in amphiphilic DNA frameworks to produce artificial organelles. WP3: Creating artificial cells by encapsulating DNA organelles in compartmentalised systems.

The full programmability afforded by NANOCELL will ultimately unlock long-awaited applications of artificial cells, spanning from biosensing to smart therapeutics.

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The information about "NANOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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