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CoEvolve SIGNED

Deconstructing and rebuilding the evolution of cell and tissue mechanoadaptation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CoEvolve project word cloud

Explore the words cloud of the CoEvolve project. It provides you a very rough idea of what is the project "CoEvolve" about.

adapt    morphogenesis    deconstruct    medicine    elicit    principles    tools    downstream    mechanoadaptation    dissect    static    adapts    spatiotemporal    exceptionally    cell    regeneration    biophysical    interactively    generating    independently    matrix    edge    physiology    cutting    cells    biomaterial    sensed    multiscale    manipulation    regenerative    instigate    variety    conventional    critical    environment    functions    play    fundamental    global    contributes    body    coordinated    granting    descriptions    broad    ecm    inspired    equally    therapeutics    progress    functional    full    unravelling    unprecedented    thereby    local    methodology    reciprocity    rebuild    tissue    mal    extracellular    paradigm    dynamic    transformation    roadmap    appreciated    behavior    constantly    co    directions    cardiomyopathies    signal    cancer    remodeling    physical    transmission    orchestrated    vitro    accommodate    diseases    mechanical    dynamics    feedback    shift    healthcare   

Project "CoEvolve" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙601 €
 EC max contribution 1˙499˙601 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 1˙499˙601.00

Map

 Project objective

Cells in our body are exceptionally robust: they constantly adapt their properties and behavior to their physical environment. Less appreciated but equally important, the extracellular matrix (ECM) around the cells also adapts to accommodate cell activity. This highly dynamic feedback between the cell and the ECM has been increasingly recognized to play a key role in not only tissue morphogenesis and functions, but also a variety of diseases, from cardiomyopathies to cancer. Moreover, it presents an unprecedented challenge in healthcare and therapeutics, especially regenerative medicine, as progress in this field requires a paradigm shift from conventional, static cell descriptions to a co-evolving cell and tissue physiology. This proposal aims to instigate this transformation by unravelling the fundamental biophysical principles behind cell–matrix dynamic reciprocity and generating a multiscale roadmap of mechanoadaptation critical in functional tissue regeneration. To achieve this goal, we will develop cutting-edge in vitro manipulation tools to deconstruct and rebuild the dynamics of cells and the ECM independently and interactively, thereby granting us full spatiotemporal control of each component in the system. Using this unique tissue-environment-inspired bottom-up approach, we will dissect how 1) physical changes in the environment are sensed and elicit response by the cell, 2) cell-induced ECM remodeling contributes to mechanical signal transmission, and 3) these local changes are orchestrated into global coordinated mechanoadaptation at the tissue level. The findings will have a broad impact on our fundamental understanding of cell and tissue physiology by identifying novel concepts in mechanoadaptation and will offer specific biomaterial design principles for tissue regeneration. The developed methodology will also advance the field in new directions by enabling further studies on downstream cell and tissue (mal)functions under dynamic conditions.

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The information about "COEVOLVE" are provided by the European Opendata Portal: CORDIS opendata.

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