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CoEvolve SIGNED

Deconstructing and rebuilding the evolution of cell and tissue mechanoadaptation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CoEvolve project word cloud

Explore the words cloud of the CoEvolve project. It provides you a very rough idea of what is the project "CoEvolve" about.

progress    contributes    cutting    instigate    fundamental    local    cell    ecm    rebuild    orchestrated    functions    reciprocity    principles    paradigm    cardiomyopathies    mechanoadaptation    unprecedented    variety    dissect    morphogenesis    behavior    matrix    equally    conventional    descriptions    spatiotemporal    diseases    play    deconstruct    biophysical    critical    cancer    shift    constantly    healthcare    elicit    interactively    manipulation    methodology    exceptionally    full    therapeutics    extracellular    adapts    unravelling    generating    feedback    medicine    static    cells    functional    dynamics    downstream    global    granting    dynamic    mechanical    coordinated    physical    inspired    transformation    adapt    tissue    roadmap    vitro    environment    directions    broad    sensed    body    regenerative    physiology    appreciated    accommodate    mal    transmission    multiscale    biomaterial    edge    thereby    independently    co    regeneration    tools    remodeling    signal   

Project "CoEvolve" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙601 €
 EC max contribution 1˙499˙601 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 1˙499˙601.00

Map

 Project objective

Cells in our body are exceptionally robust: they constantly adapt their properties and behavior to their physical environment. Less appreciated but equally important, the extracellular matrix (ECM) around the cells also adapts to accommodate cell activity. This highly dynamic feedback between the cell and the ECM has been increasingly recognized to play a key role in not only tissue morphogenesis and functions, but also a variety of diseases, from cardiomyopathies to cancer. Moreover, it presents an unprecedented challenge in healthcare and therapeutics, especially regenerative medicine, as progress in this field requires a paradigm shift from conventional, static cell descriptions to a co-evolving cell and tissue physiology. This proposal aims to instigate this transformation by unravelling the fundamental biophysical principles behind cell–matrix dynamic reciprocity and generating a multiscale roadmap of mechanoadaptation critical in functional tissue regeneration. To achieve this goal, we will develop cutting-edge in vitro manipulation tools to deconstruct and rebuild the dynamics of cells and the ECM independently and interactively, thereby granting us full spatiotemporal control of each component in the system. Using this unique tissue-environment-inspired bottom-up approach, we will dissect how 1) physical changes in the environment are sensed and elicit response by the cell, 2) cell-induced ECM remodeling contributes to mechanical signal transmission, and 3) these local changes are orchestrated into global coordinated mechanoadaptation at the tissue level. The findings will have a broad impact on our fundamental understanding of cell and tissue physiology by identifying novel concepts in mechanoadaptation and will offer specific biomaterial design principles for tissue regeneration. The developed methodology will also advance the field in new directions by enabling further studies on downstream cell and tissue (mal)functions under dynamic conditions.

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The information about "COEVOLVE" are provided by the European Opendata Portal: CORDIS opendata.

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