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HUGODECA SIGNED

Human Gonad Developmental Cell Atlas

Total Cost €

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EC-Contrib. €

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Partnership

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 HUGODECA project word cloud

Explore the words cloud of the HUGODECA project. It provides you a very rough idea of what is the project "HUGODECA" about.

ex    cleared    interactive    contributors    disorders    females    associations    testes    mechanisms    executives    brings    molecular    altering    events    dsd    patient    traits    spatial    online    omics    medical    transcriptomics    signaling    accuracy    care    developmental    integrate    scientists    expertise    analytical    data    pediatric    public    requiring    immunofluorescence    male    industrial    accompany    image    divergence    healthy    female    sex    hca    underlying    mass    cytometry    experts    cell    multidimensional    males    treatment    unprecedented    specialized    active    cellular    mimicking    technologies    complementarity    portal    multiple    ongoing    3d    assays    single    human    tools    dimensional    tested    platforms    academic    maps    composition    gonad    synergistic    understand    psychosocial    differentiation    gonadal    culture    vivo    model    ovaries    optically    gonads    atlas    hugodeca    embryonic    computational    diverge    reference    breaking    multiscale    describe    imaging    lineages    integration    ground    emerge    2d    efforts    differences    profiling    vixo    countries    clinicians    first    models    grounded    cyclic    organization   

Project "HUGODECA" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 4˙822˙198 €
 EC max contribution 4˙822˙197 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙820˙748.00
2    GENOME RESEARCH LIMITED UK (LONDON) participant 725˙810.00
3    KEEN EYE TECHNOLOGIES FR (PARIS) participant 543˙750.00
4    REGION HOVEDSTADEN DK (HILLEROD) participant 402˙800.00
5    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 354˙625.00
6    INSERM - TRANSFERT SA FR (PARIS) participant 320˙450.00
7    MILTENYI BIOTEC GMBH DE (BERGISH GLADBACH) participant 242˙812.00
8    CARTANA AB SE (SOLNA) participant 206˙250.00
9    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 204˙952.00

Map

 Project objective

The single ground-breaking goal of the HUGODECA project is to describe the cellular composition and organization of the developing human gonads and to understand how it changes during sex determination into testes in males and ovaries in females. What are the underlying mechanisms and first molecular and cellular events that accompany the differentiation and divergence of embryonic gonads? How and when do male and female cell lineages diverge and specific traits emerge? HUGODECA focuses on healthy gonad development, but our reference model will be tested using specific ex vixo assays mimicking Differences/Disorders of Sex Development (DSD). To reach this ambitious goal, the HUGODECA consortium brings together leading European academic and industrial experts (from 5 different EU countries). It includes active contributors and executives of the Human Cell Atlas (HCA) which will ensure complementarity with other ongoing HCA efforts. The overall HUGODECA concept is grounded on the integration of multiple synergistic expertise and technologies: Single cell profiling, Spatial transcriptomics, 2D Mass cytometry and cyclic immunofluorescence and 3D imaging of optically cleared gonads. HUGODECA will implement novel tools, analytical and computational methods to process and integrate multidimensional OMICS and image data across different platforms. It will evaluate the accuracy of ex vivo culture models of human gonadal development and assess consequences of altering key signaling pathways. HUGODECA will build the first multiscale developmental cell atlas and unprecedented reference maps of male and female human gonads. It will implement an interactive and multi-dimensional online portal for clinicians, scientists and public including DSD patient associations. HUGODECA shall improve our understanding of DSD, which is a major pediatric concern, requiring complex and highly specialized medical treatment and psychosocial care.

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The information about "HUGODECA" are provided by the European Opendata Portal: CORDIS opendata.

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