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HUGODECA SIGNED

Human Gonad Developmental Cell Atlas

Total Cost €

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EC-Contrib. €

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Partnership

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 HUGODECA project word cloud

Explore the words cloud of the HUGODECA project. It provides you a very rough idea of what is the project "HUGODECA" about.

disorders    contributors    signaling    ongoing    technologies    mimicking    cyclic    pediatric    interactive    patient    females    mass    academic    emerge    unprecedented    lineages    tools    dimensional    immunofluorescence    platforms    single    events    composition    vixo    omics    female    specialized    data    clinicians    assays    scientists    care    countries    model    profiling    accompany    expertise    requiring    3d    maps    vivo    integration    treatment    analytical    associations    sex    brings    males    computational    gonad    embryonic    dsd    multiscale    online    developmental    hugodeca    2d    models    differentiation    male    efforts    diverge    medical    healthy    cellular    gonads    cytometry    ovaries    culture    transcriptomics    imaging    ex    active    gonadal    mechanisms    experts    tested    integrate    testes    hca    molecular    industrial    portal    spatial    reference    accuracy    ground    underlying    public    altering    differences    first    complementarity    organization    grounded    cleared    understand    optically    psychosocial    atlas    traits    human    multidimensional    executives    breaking    divergence    multiple    cell    describe    synergistic    image   

Project "HUGODECA" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 4˙822˙198 €
 EC max contribution 4˙822˙197 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙820˙748.00
2    GENOME RESEARCH LIMITED UK (LONDON) participant 725˙810.00
3    KEEN EYE TECHNOLOGIES FR (PARIS) participant 543˙750.00
4    REGION HOVEDSTADEN DK (HILLEROD) participant 402˙800.00
5    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 354˙625.00
6    INSERM - TRANSFERT SA FR (PARIS) participant 320˙450.00
7    MILTENYI BIOTEC GMBH DE (BERGISH GLADBACH) participant 242˙812.00
8    CARTANA AB SE (SOLNA) participant 206˙250.00
9    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 204˙952.00

Map

 Project objective

The single ground-breaking goal of the HUGODECA project is to describe the cellular composition and organization of the developing human gonads and to understand how it changes during sex determination into testes in males and ovaries in females. What are the underlying mechanisms and first molecular and cellular events that accompany the differentiation and divergence of embryonic gonads? How and when do male and female cell lineages diverge and specific traits emerge? HUGODECA focuses on healthy gonad development, but our reference model will be tested using specific ex vixo assays mimicking Differences/Disorders of Sex Development (DSD). To reach this ambitious goal, the HUGODECA consortium brings together leading European academic and industrial experts (from 5 different EU countries). It includes active contributors and executives of the Human Cell Atlas (HCA) which will ensure complementarity with other ongoing HCA efforts. The overall HUGODECA concept is grounded on the integration of multiple synergistic expertise and technologies: Single cell profiling, Spatial transcriptomics, 2D Mass cytometry and cyclic immunofluorescence and 3D imaging of optically cleared gonads. HUGODECA will implement novel tools, analytical and computational methods to process and integrate multidimensional OMICS and image data across different platforms. It will evaluate the accuracy of ex vivo culture models of human gonadal development and assess consequences of altering key signaling pathways. HUGODECA will build the first multiscale developmental cell atlas and unprecedented reference maps of male and female human gonads. It will implement an interactive and multi-dimensional online portal for clinicians, scientists and public including DSD patient associations. HUGODECA shall improve our understanding of DSD, which is a major pediatric concern, requiring complex and highly specialized medical treatment and psychosocial care.

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The information about "HUGODECA" are provided by the European Opendata Portal: CORDIS opendata.

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