Opendata, web and dolomites

PROTEOFIT SIGNED

Adapting protein fate for muscle function and fitness

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "PROTEOFIT" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙746˙825 €
 EC max contribution 1˙746˙825 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2024-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙746˙825.00

Map

 Project objective

Muscle function is essential for motion, exercise, and shivering, whereas physical inactivity is causally related to reduced metabolic fitness in animal models and humans. A critical requirement for muscle function is that proteins are properly produced and, if necessary, degraded to adapt the proteome to meet metabolic demands. However, there is a fundamental, open gap in understanding how challenges to muscle proteostasis are sensed and how protein fate is subsequently adapted to enhance muscle function in exercise or, conversely, how it is compromised in obesity. I hypothesize that protein fate is highly adaptive and can be fine-tuned to promote proteostasis, the integrity of muscle cells, and metabolic health. Identifying novel key regulators of these mechanisms in muscle may hold great therapeutic promise for targeting metabolic fitness to combat obesity and associated disorders. In this innovative project I want to define new mechanisms of muscle adaptation in humans and preclinical mouse models, with the ultimate goal of using this knowledge to improve muscle function and fitness in obesity. I will identify exercise- and obesity-specific substrates of the proteasome by ubiquitomics in human and mouse muscle and define how the ubiquitination and turnover of these proteins dictates muscle cell function. In a complementary approach, I will use novel loss- and gain-of-function mouse models allowing for precise muscle-specific manipulation of Nfe2l1, an adaptive regulator of proteasomal protein degradation, to define the biological and therapeutic significance of this pathway for muscle function in exercise and obesity. In summary, this novel work will provide a transformative molecular understanding of muscle adaption to metabolic challenges and provide insight into how this translates into metabolic fitness and the development of obesity and associated disorders in humans.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PROTEOFIT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PROTEOFIT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KEYNESGROWTH (2020)

Economic Fluctuations, Productivity Growth and Stabilization Policies: A Keynesian Growth Perspective

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More