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Brillouin4Life SIGNED

Development of advanced optical tools for studying cellular mechanics at high spatial and temporal resolution

Total Cost €

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EC-Contrib. €

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Partnership

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 Brillouin4Life project word cloud

Explore the words cloud of the Brillouin4Life project. It provides you a very rough idea of what is the project "Brillouin4Life" about.

photodamage    imaging    difficulties    biology    innovative    interdisciplinary    mechanical    improvements    temporal    lately    invasive    plane    combine    resolution    technologies    developmental    revolutionary    quantification    started    contact    quantify    life    phototoxicity    ongoing    fellow    materials    time    thereby    morphogenesis    label    encoded    emerged    microscopy    implementations    routinely    technique    advancements    understand    cellular    tissue    suffer    visualized    datasets    probe    shape    obtain    accurately    fashion    assessing    investigations    virtually    modalities    despite    spatio    self    interactions    biophysics    visco    measured    minimizing    compartments    biologists    free    brillouin    genome    limited    drawbacks    organisation    tool    elastic    elastography    interwoven    cells    3d    living    optical    destructive    fluorescence    components    multiplexed    maximize    multicellular    biomechanics    illumination    bm    prohibiting    penetration    live    mechanics    diffraction    organismal    methodological    molecular    overcome    correlative    sciences    group    selective    speed    elasticity   

Project "Brillouin4Life" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙289 €
 EC max contribution 1˙999˙289 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙999˙289.00

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 Project objective

A long-standing aim in the life sciences is to understand development and morphogenesis, i.e. how organismal shape is encoded by the genome and how cellular mechanics are involved in its execution. Lately, investigations have started to focus on the mechanical properties of the involved multicellular compartments, and the interwoven mechanical - molecular interactions at the cellular scale. While molecular components can routinely be visualized with fluorescence microscopy, assessing the mechanical properties of living cells with similar spatio-temporal resolution in a non-invasive fashion has long been an open challenge.

Recently, a new type of optical elastography, namely Brillouin microscopy (BM), has emerged as a non-destructive, label- and contact-free technique which can probe visco-elastic properties of materials with diffraction-limited resolution in 3D. Yet, despite ongoing improvements, virtually all current implementations suffer from very low speed, high phototoxicity, and difficulties in quantification, thus prohibiting meaningful investigations in the life sciences.

In this interdisciplinary proposal, my group will develop unique and innovative optical imaging technologies based on BM to overcome its current drawbacks and to establish it as a revolutionary tool for live tissue and cellular biophysics studies. In particular, we will work towards a highly-multiplexed BM with selective-plane illumination to maximize speed, resolution and depth penetration, while minimizing photodamage (Aim 1). At the same time, we will combine BM with other imaging modalities that will allow us to obtain correlative datasets and to accurately quantify the measured mechanical properties (Aim 2). We will then apply these methodological advancements together with fellow biologists to study the role of elasticity in tissue morphogenesis and self-organisation, thereby contributing to a better understanding of the role of biomechanics in developmental biology (Aim 3).

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The information about "BRILLOUIN4LIFE" are provided by the European Opendata Portal: CORDIS opendata.

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