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CCMuPWA SIGNED

Characterize corpus callosum-mediated local and global inhibitory effects with novel MRI-compatible photonic crystal fiber-based multifunction probe and wireless amplified NMR detector in rat brain

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CCMuPWA project word cloud

Explore the words cloud of the CCMuPWA project. It provides you a very rough idea of what is the project "CCMuPWA" about.

coil    models    calcium    detector    cc    crystal    rat    signal    decipher    optic    layer    contributions    corpus    wand    body    balance    pcf    cortex    amplified    excitation    function    callosum    rf    autism    normal    spatial    probe    lately    brain    structural    nuclear    mental    causal    photonic    influence    optogenetic    mr    fmri    imaging    technologies    implanted    diseased    combined    cortical    unclear    neuroglial    mediated    epilepsy    exactly    local    fiber    noise    cellular    kidney    circuitry    astrocytic    recording    modified    merge    inhibition    sensitivity    ascending    neuron    signals    optogenetics    patients    cutting    schizophrenia    multiple    temporal    retardation    enhanced    mapping    manipulation    barrel    ratio    activation    injection    anomalies    modal    thalamocortical    vivo    animal    functional    wireless    incorporated    rats    interactions    resolution    found    neuronal    pairing    edge    successfully    global    previously    astrocyte    platform    disorders    scales    correlated    callosal    optimize    dynamic    recordings    fluid   

Project "CCMuPWA" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 205˙352 €
 EC max contribution 205˙352 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 205˙352.00
2    MICHIGAN STATE UNIVERSITY US (EAST LANSING, MICHIGAN) partner 0.00

Map

 Project objective

The structural anomalies of corpus callosum (CC) in patients are found highly-correlated with a wide range of disorders, e.g., epilepsy, autism, schizophrenia and mental retardation. However, it remains unclear about the causal contributions of CC-mediated functional changes to these disorders and exactly how the changes influence the local cortical circuitry. Lately, we have successfully combined fMRI with fiber optic mediated calcium recordings and optogenetics, i.e., multi-modal fMRI, to study the balance of excitation/inhibition in the barrel cortex in rats by pairing optogenetic corpus callosum activation with ascending thalamocortical activation. However, it remains challenging to maintain high sensitivity to the brain dynamic signal and better decipher CC-mediated unique cellular (neuron/astrocyte) or layer-specific contributions to the local cortical or global whole-brain fMRI signals. Therefore, the goal of this proposal is to optimize the multi-modal fMRI platform and to characterize the brain activity upon optogenetic callosal activation with higher spatial/temporal resolution using two cutting edge technologies, wireless amplified nuclear MR detector (WAND) and photonic crystal fiber (PCF). Previously, we have implanted a wireless RF coil into the rat body to achieve a high signal-to-noise ratio and spatial resolution for in vivo kidney imaging. The modified WAND will be incorporated into the multi-modal fMRI platform to achieve brain dynamic signal with enhanced sensitivity from the barrel cortex. Next, we will merge it with a novel PCF-based probe integrated calcium recording, optogenetic manipulation and fluid injection function. This proposal will merge the neuronal and astrocytic dynamic signals to the functional mapping, solve the challenges for CC study at multiple scales in the brain, enable novel applications of the multi-modal fMRI platform to better decipher the neuroglial interactions in normal and diseased animal models for future studies.

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The information about "CCMUPWA" are provided by the European Opendata Portal: CORDIS opendata.

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