R-GNOSIS

Resistance in Gram-Negative Organisms: Studying Intervention Strategies

 Coordinatore UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Dr.
Nome: E.
Cognome: Van Geenen
Email: send email
Telefono: 3188756818

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 15˙654˙161 €
 EC contributo 11˙999˙999 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2011-single-stage
 Funding Scheme CP-IP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Dr.
Nome: E.
Cognome: Van Geenen
Email: send email
Telefono: 3188756818

NL (UTRECHT) coordinator 3˙895˙124.89
2    THE FOUNDATION FOR MEDICAL RESEARCHINFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV

 Organization address address: WEIZMANN STREET 6
city: Tel Aviv
postcode: 64239

contact info
Titolo: Ms.
Nome: Meital
Cognome: Kazma-Matalon
Email: send email
Telefono: 97236973625

IL (Tel Aviv) participant 1˙295˙720.00
3    CARDIFF UNIVERSITY

 Organization address address: Newport Road 30-36
city: CARDIFF
postcode: CF24 ODE

contact info
Titolo: Ms.
Nome: Eevi
Cognome: Laukkanen
Email: send email
Telefono: +4429 2087 0114

UK (CARDIFF) participant 986˙549.00
4    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Stephan
Cognome: Harbarth
Email: send email
Telefono: +41 22 372 33 57

CH (GENEVE) participant 901˙272.30
5    UNIVERSITEIT ANTWERPEN

 Organization address address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000

contact info
Titolo: Ms.
Nome: Anne
Cognome: Adams
Email: send email
Telefono: +32 3 265 30 28

BE (ANTWERPEN) participant 847˙490.00
6    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Fraessdorf
Email: send email
Telefono: +49 30 450576024
Fax: +49 30 450576954

DE (BERLIN) participant 756˙573.00
7    UNIVERSITE PARIS XII VAL DE MARNE

 Organization address address: AVENUE DU GENERAL DE GAULLE 61
city: CRETEIL
postcode: 94010

contact info
Titolo: Mr.
Nome: Nicolas
Cognome: Vautrin
Email: send email
Telefono: +33 1 45 17 14 15

FR (CRETEIL) participant 450˙111.10
8    SERVICIO MADRILENO DE SALUD

 Organization address address: PLAZA CARLOS TRIAS BERTRAN 7
city: MADRID
postcode: 28020

contact info
Titolo: Mr.
Nome: José Ignacio
Cognome: Flores Nicolás
Email: send email
Telefono: +34 91 3368147

ES (MADRID) participant 410˙922.00
9    ARTTIC

 Organization address address: Rue du Dessous des Berges 58A
city: PARIS
postcode: 75013

contact info
Titolo: Dr.
Nome: Eric
Cognome: Papon
Email: send email
Telefono: 33153945460

FR (PARIS) participant 407˙000.00
10    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Dr.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

UK (OXFORD) participant 392˙153.00
11    Department of Health

 Organization address address: Quarry House, Quarry Hill
city: Leeds
postcode: LS2 7UE

contact info
Titolo: Ms.
Nome: Ann
Cognome: Grant
Email: send email
Telefono: 442083000000

UK (Leeds) participant 319˙142.32
12    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Mr.
Nome: Christophe
Cognome: Misse
Email: send email
Telefono: +33 1 40 27 46 13

FR (PARIS) participant 272˙146.40
13    UNIVERSITY OF SOUTHAMPTON

 Organization address address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ

contact info
Titolo: Ms.
Nome: Yan
Cognome: Qiao
Email: send email
Telefono: +442380 593907

UK (SOUTHAMPTON) participant 238˙905.00
14    SOCIEDAD ESPANOLA DE MEDICINA DE FAMILIA Y COMUNITARIA

 Organization address address: C PORTAFERRISSA 8
city: BARCELONA
postcode: 8002

contact info
Titolo: Mr.
Nome: Joan
Cognome: Saumell
Email: send email
Telefono: 34933170333

ES (BARCELONA) participant 195˙808.00
15    DA VOLTERRA SAS

 Organization address address: RUE DE CHARONNE 172
city: PARIS
postcode: 75011

contact info
Titolo: Ms.
Nome: Florence
Cognome: Séjourné
Email: send email
Telefono: +33 1 58 39 32 20

FR (PARIS) participant 177˙039.20
16    UNIVERSITE DE FRIBOURG

 Organization address address: AVENUE DE L'EUROPE 20
city: FRIBOURG
postcode: 1700

contact info
Titolo: Ms.
Nome: Monique
Cognome: Bersier
Email: send email
Telefono: +41 26 300 7003

CH (FRIBOURG) participant 150˙557.45
17    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Ms.
Nome: Sandra
Cognome: Mereu
Email: send email
Telefono: +33 1 69 15 37 22
Fax: +33 1 69 15 55 99

FR (ORSAY) participant 84˙942.55
18    STATENS SERUM INSTITUT

 Organization address address: ARTILLERIVEJ 5
city: KOBENHAVN S
postcode: 2300

contact info
Titolo: Dr.
Nome: Lars Villiam
Cognome: Pallesen
Email: send email
Telefono: 4532683130

DK (KOBENHAVN S) participant 77˙268.00
19    GENEWAVE SAS

 Organization address address: RUE PIERRE FONTAINE 4
city: EVRY
postcode: 91000

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Loiseau
Email: send email
Telefono: 33155251704

FR (EVRY) participant 51˙411.11
20    CHECK-POINTS HEALTH BV

 Organization address address: BINNENHAVEN 5
city: WAGENINGEN
postcode: 6709 PD

contact info
Titolo: Ms.
Nome: Niki
Cognome: Beelen
Email: send email
Telefono: +31 317 453 908

NL (WAGENINGEN) participant 48˙750.00
21    HUMFRYX S.C

 Organization address address: ROGER DE FLOR 211 PLANTA 3-2a
city: BARCELONA
postcode: 8025

contact info
Titolo: Dr.
Nome: Josep Maria
Cognome: Cots Yago
Email: send email
Telefono: 34934593563

ES (BARCELONA) participant 40˙482.00
22    HEALTH PROTECTION AGENCY HPA

 Organization address address: Central Office - 7th Floor, Holborn Gate - High Holborn 330
city: LONDON
postcode: WC1V 7PP

contact info
Titolo: Ms.
Nome: Ann
Cognome: Grant
Email: send email
Telefono: 442083000000

UK (LONDON) participant 631.68
23    APTATECK BIO LTD

 Organization address address: GOLDA MEIR BOULEVARD 7
city: NESS ZIONA
postcode: 74036

contact info
Titolo: Dr.
Nome: Ofer
Cognome: Nussbaum
Email: send email
Telefono: 972508000000

IL (NESS ZIONA) participant 0.00
24    UNIVERSITE PARIS DIDEROT - PARIS 7

 Organization address address: RUE THOMAS MANN 5
city: PARIS
postcode: 75205

contact info
Titolo: Ms.
Nome: Anne
Cognome: Bonvalet
Email: send email
Telefono: +33 1 57 27 55 59

FR (PARIS) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

patients    data    care    rapid    gut    antibiotic    strategy    carriage    patient    gnosis    emergence    faeces    preventive    clinical    drug    resistant    international    interventions    gram    intensive    effectiveness    enterobacteriaceae    hospital    primary    gnb    resistance    transmission    contact    mdr    bacteria    trial    innovative    esbl    decolonization    edge    strategies    producing    health    infection    studying    intervention    organisms    wards    surgery    isolation    efficacy    uncomplicated    point    negative    topical    diagnostic    prescription    cutting    mathematical    intestinal    predict    decolonisation    antibiotics    infections    recolonisation    evidence    prophylaxis    spread   

 Obiettivo del progetto (Objective)

'Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most relevant patient populations - the efficacy and effectiveness of cutting-edge interventions to reduce carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB). All work-packages will progress science beyond the state-of-the-art in generating new and translational clinically relevant knowledge, through hypothesis-driven studies focussed on patient-centred outcomes. The 5 clinical studies will investigate the following interventions: •A Point-Of-Care-Testing guided management strategy to improve appropriate antibiotic prescription for uncomplicated UTI in primary care. •Gut decolonization in outpatients with intestinal carriage of MDR-GNB. •A “test and prescribe” strategy, based on rapid diagnostic testing of faeces for MDR-GNB to optimize antibiotic prophylaxis in colo-rectal surgery. •Contact Isolation of patients with ESBL-producing Enterobacteriaceae in general hospital wards. •Three Decolonization strategies in ICUs. Seven laboratories across Europe will perform microbiological analyses, as well as unique quantitative experiments. All information will be integrated by 3 groups of mathematical modellers into highly innovative models to better understand and predict future trends and effects of interventions. The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians and health-care authorities, to combat the spread and impact of infections caused by MDR-GNB in Europe.'

Introduzione (Teaser)

Five European studies are working to revolutionise screening and treatment practices in healthcare settings and primary care to minimise transmission of drug-resistant bacteria.

Descrizione progetto (Article)

Over the past years, the injudicious use of antibiotics has led to a dramatic increase in the emergence of drug resistance. According to European health authorities, multi-drug resistant gram-negative bacteria (MDR-GNB) infections resulted in thousands of deaths and millions of hospitalisations. These statistics illustrate the urgent need of developing novel strategies for minimising the emergence and transmission of resistant microbial species.

The EU-funded http://www.r-gnosis.eu/ (R-GNOSIS) (Resistance in gram-negative organisms: studying intervention strategies) project is assessing the efficacy and effectiveness of cutting-edge interventions in reducing MDR-GNB transmission through five international clinical intervention studies.

The first of these studies entail the development of a point-of-care-testing strategy for diagnosing uncomplicated urinary tract infection to improve the overall management of antibiotic prescription. The efficacy of another rapid diagnostic test is being assessed for the detection of MDR-GNB in faeces as a means of providing antibiotic prophylaxis in colorectal surgery.

In a trial with patients carrying intestinal MDR-GNB, R-GNOSIS proceeded with decolonisation using high concentrations of topical antibiotics and subsequent gut recolonisation with faecal microbiota. This procedure has already shown efficacy against recurrent infections with Clostridium difficile and this approach is now being pursued in patients carrying MDR-GNB.

During an international trial in 15 intensive care units R-GNOSIS is evaluating the effectiveness of decolonisation using topical antibiotics to prevent infections with and transmission of MDR-GNB.

An additional ongoing study includes the contact isolation of patients with ESBL-producing Enterobacteriaceae in general hospital wards using alcohol hand rub dispensers.

Collectively, these studies will provide the material for studying fundamental biological aspects of the MDR-GNB-host interaction in the presence and absence of antibiotic selection pressure. Researchers are also investigating the mechanisms associated with the emergence and persistence of drug resistance, and are combining modelling approaches to predict plasmid transmissibility.

R-GNOSIS will offer necessary evidence for using antibiotics as a preventive strategy in intensive care patients as well as for patients after abdominal operations. The decolonisation-recolonisation data will also provide innovative approaches for dealing with persistent potentially life-threatening infections.

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KALADRUG-R (2008)

New tools for monitoring drug resistance and treatment response in visceral leishmaniasis in the Indian subcontinent

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INSPIRE (2014)

Innovative methodology for small populations research

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DECIDE (2011)

Developing and Evaluating Communication strategies to support Informed Decisions and practice based on Evidence

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