BIOSTAT-CHF

A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure

 Coordinatore ACADEMISCH ZIEKENHUIS GRONINGEN 

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Ms.
Nome: Carla
Cognome: Hooijschuur
Email: send email
Telefono: 31503612178
Fax: +31 50 3614391

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.biostat-chf.eu/
 Totale costo 15˙618˙635 €
 EC contributo 11˙894˙287 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-single-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-04-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Ms.
Nome: Carla
Cognome: Hooijschuur
Email: send email
Telefono: 31503612178
Fax: +31 50 3614391

NL (GRONINGEN) coordinator 3˙345˙849.20
2    UNIVERSITY OF LEICESTER

 Organization address address: University Road
city: LEICESTER
postcode: LE1 7RH

contact info
Titolo: Ms.
Nome: Marie
Cognome: Adams
Email: send email
Telefono: +44 116 223 1799
Fax: +44 116 252 2028

UK (LEICESTER) participant 2˙939˙250.00
3    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Fräßdorf
Email: send email
Telefono: +49 30 450576024
Fax: +49 30 450576954

DE (BERLIN) participant 950˙262.00
4    UNIVERSITY OF DUNDEE

 Organization address address: Nethergate
city: DUNDEE
postcode: DD1 4HN

contact info
Titolo: Prof.
Nome: Chim
Cognome: Lang
Email: send email
Telefono: +44 1382 236375
Fax: +44 1382386765

UK (DUNDEE) participant 869˙724.20
5    UNIVERSITA DEGLI STUDI DI BRESCIA

 Organization address address: Piazza Del Mercato 15
city: BRESCIA
postcode: 25121

contact info
Titolo: Dr.
Nome: Aldo
Cognome: Cuzzucoli
Email: send email
Telefono: 39030398404
Fax: 390304000000

IT (BRESCIA) participant 820˙050.00
6    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Ms.
Nome: Clementia.C.M. (Tineke)
Cognome: Kranendonk-Van Der Ploeg
Email: send email
Telefono: +31 20 5666542
Fax: +31 20 6915462

NL (AMSTERDAM) participant 620˙000.40
7    UNIVERSITY OF HULL

 Organization address address: COTTINGHAM ROAD
city: HULL
postcode: HU6 7RX

contact info
Titolo: Mr.
Nome: Wayne
Cognome: Sheedy
Email: send email
Telefono: +44 1482 624069
Fax: +44 1482 624069

UK (HULL) participant 490˙017.44
8    AKADEMIA MEDYCZNA IM PIASTOW SLASKICH WE WROCLAWIU AM WROCLAW

 Organization address address: UL PASTEURA 1
city: WROCLAW
postcode: 50 367

contact info
Titolo: Ms.
Nome: Agnieszka
Cognome: Urbanska
Email: send email
Telefono: +48 71 784 1142
Fax: +48 71 784 0034

PL (WROCLAW) participant 489˙999.60
9    NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

 Organization address address: CHRISTOU LADA 6
city: ATHENS
postcode: 10561

contact info
Titolo: Ms.
Nome: Efi
Cognome: Kafentzi
Email: send email
Telefono: 302104000000
Fax: 302104000000

EL (ATHENS) participant 489˙999.60
10    FONDATION TRANSPLANTATION

 Organization address address: rue de la Brot 4
city: St Apollinaire
postcode: 21850

contact info
Titolo: Ms.
Nome: Stéphanie
Cognome: Grojean
Email: send email
Telefono: +33 3 83 65 66 14
Fax: +33 3 83 65 66 23

FR (St Apollinaire) participant 489˙855.00
11    HELSE STAVANGER HF

 Organization address address: GERD RAGNA BLOCH THORSENS GATE 8
city: Stavanger
postcode: 4011

contact info
Titolo: Prof.
Nome: Kenneth
Cognome: Dickstein
Email: send email
Telefono: +47 51519453
Fax: +47 51519921

NO (Stavanger) participant 389˙280.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

prognosis    demographic    biostat    recommended    model    poor    heart    biomarkers    proteomic    patients    outcome    chf    despite    chronic    patient    initial    genomic    care    treatment    life    therapies    therapy    then    improvements    cohort   

 Obiettivo del progetto (Objective)

'Heart failure is common in Europe and its prevalence is increasing as our population ages. Despite major improvements in care since the early 90s, it is still related to a poor prognosis, an impaired quality of life and high health care costs. Many new therapies have failed to improve outcome further. One obvious reason is that the response to treatment is not homogenous. Treatment may need to be tailored to the individual patient. BIOSTAT-CHF aims to identify patients with a poor outcome, despite currently recommended therapy using information on demographics, gender, existing biomarkers, genetics and proteomics. Both genomic and proteomic analyses recently underwent major technical improvements, resulting in genome-wide analyses and detection of low abundance proteins. In BIOSTAT-CHF an index cohort of 2500 patients hospitalized with acute decompensated heart failure, will be recruited after initial stabilization. Treatment will be optimized according to the heart failure guidelines of the European Society of Cardiology with diuretics, ACE-inhibitors, betablockers and aldosterone antagonists. When patients are optimally treated, any change in symptoms and exercise tolerance will be evaluated. Patients will then be followed up for a mean of 18 months, and mortality and heart failure hospitalizations will be recorded. By using a systems biology approach, incorporating information from demographic, biomarker, genomic, proteomic, and the initial response to therapy, a risk prediction model will be designed, identifying patients with a poor outcome on currently recommended therapy. This model will then be validated in a real-life cohort of 2500 chronic heart failure patients. BIOSTAT-CHF will therefore be a major step towards personalized medicine. Identifying patients with a poor outcome on currently recommended therapy might lead to further development of targeted therapies, eventually leading to improvements in outcome for patients with heart failure in Europe'

Introduzione (Teaser)

Effective chronic heart failure treatments should be patient-specific. To identify specific biomarkers of the disease, the BIOSTAT-CHF project aims to identify patients with a poor prognosis and analyse demographic, genetic and proteomic information.

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