MULTIBIODOSE
Multi-disciplinary biodosimetric tools to manage high scale radiological casualties
| Coordinatore | STOCKHOLMS UNIVERSITET
Organization address
address: Universitetsvaegen 10 contact info |
| Nazionalità Coordinatore | Sweden [SE] |
| Sito del progetto | http://www.multibiodose.eu/ |
| Totale costo | 4˙580˙243 € |
| EC contributo | 3˙493˙199 € |
| Programma | FP7-SECURITY
Specific Programme "Cooperation": Security |
| Code Call | FP7-SEC-2009-1 |
| Funding Scheme | CP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-05-01 - 2013-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
STOCKHOLMS UNIVERSITET
Organization address
address: Universitetsvaegen 10 contact info |
SE (STOCKHOLM) | coordinator | 536˙149.40 |
| 2 |
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
Organization address
address: Avenue de la Division Leclerc 31 contact info |
FR (FONTENAY AUX ROSES) | participant | 780˙732.50 |
| 3 |
HEALTH PROTECTION AGENCY HPA
Organization address
address: Central Office - 7th Floor, Holborn Gate - High Holborn 330 contact info |
UK (LONDON) | participant | 336˙575.25 |
| 4 |
UNIVERSITEIT GENT
Organization address
address: SINT PIETERSNIEUWSTRAAT 25 contact info |
BE (GENT) | participant | 288˙960.00 |
| 5 |
UNIVERSITAET ULM
Organization address
address: HELMHOLTZSTRASSE 16 contact info |
DE (ULM) | participant | 228˙960.00 |
| 6 |
BUNDESAMT FUER STRAHLENSCHUTZ
Organization address
address: Willy-Brandt-Strasse 5 contact info |
DE (SALZGITTER) | participant | 228˙000.00 |
| 7 |
ISTITUTO SUPERIORE DI SANITA
Organization address
address: Viale Regina Elena 299 contact info |
IT (ROMA) | participant | 199˙800.00 |
| 8 |
SATEILYTURVAKESKUS
Organization address
address: Laippatie 4 contact info |
FI (HELSINKI) | participant | 174˙652.50 |
| 9 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 166˙637.70 |
| 10 |
Department of Health
Organization address
address: Quarry House, Quarry Hill contact info |
UK (Leeds) | participant | 145˙587.25 |
| 11 |
NORWEGIAN RADIATION PROTECTION AUTHORITY
Organization address
address: GRINI NAERINGSPARK 13 contact info |
NO (OSTERAAS) | participant | 122˙325.00 |
| 12 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 100˙680.00 |
| 13 |
UNIVERSITAT AUTONOMA DE BARCELONA
Organization address
address: Campus UAB -BELLATERRA- s/n contact info |
ES (CERDANYOLA DEL VALLES) | participant | 86˙400.00 |
| 14 |
INSTYTUT CHEMII I TECHNIKI JADROWEJ
Organization address
address: ul. Dorodna 16 contact info |
PL (WARSZAWA) | participant | 85˙140.00 |
| 15 |
EUROPEAN RADIATION DOSIMETRY GROUP E.V.
Organization address
address: Bundesallee 100 contact info |
DE (Braunschweig) | participant | 12˙600.00 |
| 16 |
WESTLAKES SCIENTIFIC CONSULTING LTD
Organization address
address: "The princess Royal Building Westlakes Science and Technology Park, Moor Row Princess Royal" contact info |
UK (Whitehaven) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'In the event of a large scale radiological emergency biological dosimetry is an essential tool that can provide timely assessment of radiation exposure to the general population and enable the identification of those exposed people, who should receive medical treatment. A number of biodosimetric tools are potentially available, but they must be adapted and tested for a large-scale emergency scenario. These methods differ in their specificity and sensitivity to radiation, the stability of signal and speed of performance. A large scale radiological emergency can take different forms. Based on the emergency scenario different biodosimetric tools should be applied so that the dosimetric information can be made available with optimal speed and precision. The aim of this multi-disciplinary collaborative project is to analyse a variety of biodosimetric tools and adapt them to different mass casualty scenarios. The following biodosimetric tools will be validated and established: the dicentric assay, the micronucleus assay, the gamma-H2AX assay, the skin speckle assay, the blood serum protein expression assay and EPR/OSL dosimetry in components of pocket electronic devises. The assays were chosen because they complement each other with respect to sensitivity, specificity to radiation and the exposure scenario as well as speed of performance. The project will involve the key European players with extensive experience in biological dosimetry. Training will be carried out and automation and commercialisation pursued. An operational guide will be developed and disseminated among emergency preparedness and radiation protection organisations. The final deliverable of this project will be establishment of a biodosimetric network that is fully functional and ready to respond in case of a mass casualty. Thus, the project will strengthen the European security capabilities by achieving tangible results.'
Introduzione (Teaser)
Radiation exposure involves many variables that must be untangled to quickly determine which individuals require immediate treatment. A network of laboratories has developed a toolkit to effectively triage a large-scale emergency situation.
Descrizione progetto (Article)
A number of biodosimetric tools exist to assess the dose a person has received. They vary in sensitivity, specificity, stability of signal and speed of performance. The EU-funded project 'Multi-disciplinary biodosimetric tools to manage high scale radiological casualties' (http://www.multibiodose.eu/ (MULTIBIODOSE)) tested and adapted these tools for the worst-case, large-scale scenario.
The toolkit has five complementary assays. Training was provided to laboratory personnel and the assays were tested on irradiated blood samples and mobile phones. Three triage categories were assigned according to identified dosage level. A statistical tool available on the project website was developed to collate results and provide standard errors and other measures for dose determination.
Team members found that using dose estimates alone without considering the standard errors and upper confidence limits was without exception the most successful categorisation method. This is particularly important as it demonstrates the accuracy of the dose estimates obtained with the assays in providing a realistic picture of actual exposure dose.
A guidance document for radiation emergency responders is freely available for download from the website. The document also highlights the limitations of the triage tools and the capacity of the participating laboratories to carry out biodosimetric triage in a mass casualty emergency.
MULTIBIODOSE partner laboratories are now prepared to coordinate and administer a response campaign in an emergency situation. They are now the largest network in the world with this competence. Working closely with other laboratories and radiation and health authorities regarding collection and testing of samples, they will support medical and public health decisions. The technology and coordination know-how should have significant impact on the ability of authorities to respond quickly and effectively in the case of mass radiation exposure.