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Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds

Total Cost €


EC-Contrib. €






Project "EDC-MixRisk" data sheet

The following table provides information about the project.


Organization address
address: Nobels Vag 5
postcode: 17177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 6˙223˙330 €
 EC max contribution 6˙223˙330 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙089˙181.00
2    KARLSTADS UNIVERSITET SE (KARLSTAD) participant 1˙194˙481.00
3    LUNDS UNIVERSITET SE (LUND) participant 585˙000.00
5    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 450˙061.00
7    UPPSALA UNIVERSITET SE (UPPSALA) participant 418˙532.00
10    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 316˙750.00
12    OREBRO UNIVERSITY SE (OREBRO) participant 252˙030.00
13    UNIVERSITAET LEIPZIG DE (LEIPZIG) participant 62˙500.00


 Project objective

A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns, there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particular in mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management. This project is designed to promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need for improved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risks for multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDC mixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimental toxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identification of EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth and metabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanisms and pathways underlying the associations between exposure and adverse health outcomes by the use and development of state-of-the-art experimental models and iii) Development of a transparent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societal impact, thus promoting better risk management for EDCs and their mixtures.


List of deliverables.
Report on how to ensure workability of the IPCS definition of EDCs Documents, reports 2019-11-20 11:44:50
Report on a novel framework for risk assessment of mixtures Documents, reports 2019-11-20 11:44:50
4th Report from the Scientific Advisory Board meeting Documents, reports 2019-11-20 11:44:50
Report EDC mixtures III Documents, reports 2019-11-20 11:44:50
Report on inclusive strategies for the regulatory implementation of risk assessment tools for EDC mixtures Documents, reports 2019-11-20 11:44:50
3rd Report from the Scientific Advisory Board meeting Documents, reports 2019-11-20 11:44:50
Data management plan document Open Research Data Pilot 2019-11-20 11:44:50
Report on chemical levels in SELMA and Life Child. Documents, reports 2019-11-20 11:44:50
Internal communication plan document Documents, reports 2019-11-20 11:44:50
1st Dissemination activity and quality report Documents, reports 2019-11-20 11:44:50
Report on critical EDC mixtures I Documents, reports 2019-11-20 11:44:50
Comprehensive information about ECD-MixRisk in EN, SE, FR, DE, FI, GR, IT Websites, patent fillings, videos etc. 2019-11-20 11:44:49
2nd Dissemination activity and quality report Documents, reports 2019-11-20 11:44:50
Whitepaper on EDCs and health risks Documents, reports 2019-11-20 11:44:50
2nd Report from the Scientific Advisory Board meeting Documents, reports 2019-11-20 11:44:50
Meeting report of the WHO Chemical Risk Assessment Network Documents, reports 2019-11-20 11:44:50
1st Report from Scientific Advisory Board meeting Documents, reports 2019-11-20 11:44:50
Project guideline document Documents, reports 2019-11-20 11:44:49
Launch of webpage Websites, patent fillings, videos etc. 2019-11-20 11:44:49
Dissemination guideline Documents, reports 2019-11-20 11:44:50
Report on doses and exposure regiments for experimental studies with mixtures I Documents, reports 2019-11-20 11:44:49
Report on doses and exposure regiments for experimental studies with mixtures 0 Documents, reports 2019-11-20 11:44:49

Take a look to the deliverables list in detail:  detailed list of EDC-MixRisk deliverables.


year authors and title journal last update
List of publications.
2019 Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R. Tuck, Marcus O. D. Sjödin, Johan Lindberg, Evangelos Bozas, Joëlle Rüegg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki
Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42377-6
Scientific Reports 9/1 2019-11-20
2019 Carl‐Gustaf Bornehag, Efthymia Kitraki, Antonios Stamatakis, Emily Panagiotidou, Christina Rudén, Huan Shu, Christian Lindh, Joelle Ruegg, Chris Gennings
A Novel Approach to Chemical Mixture Risk Assessment—Linking Data from Population‐Based Epidemiology and Experimental Animal Tests
published pages: , ISSN: 0272-4332, DOI: 10.1111/risa.13323
Risk Analysis 2019-11-20
2019 Petra Spirhanzlova, Michelle Leemans, Barbara A. Demeneix, Jean-Baptiste Fini
Following Endocrine-Disrupting Effects on Gene Expression in Xenopus laevis
published pages: pdb.prot098301, ISSN: 1559-6095, DOI: 10.1101/pdb.prot098301
Cold Spring Harbor Protocols 2019/7 2019-11-20
2018 Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Current EU research activities on combined exposure to multiple chemicals
published pages: 544-562, ISSN: 0160-4120, DOI: 10.1016/j.envint.2018.07.037
Environment International 120 2019-11-20
2018 Bilal B Mughal, Jean-Baptiste Fini, Barbara A Demeneix
Thyroid-disrupting chemicals and brain development: an update
published pages: R160-R186, ISSN: 2049-3614, DOI: 10.1530/EC-18-0029
Endocrine Connections 7/4 2019-11-20
2018 Ali Alavian-Ghavanini, Ping-I Lin, P. Monica Lind, Sabina Risén Rimfors, Margareta Halin Lejonklou, Linda Dunder, Mandy Tang, Christian Lindh, Carl-Gustaf Bornehag, Joëlle Rüegg
Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29732-9
Scientific Reports 8/1 2019-11-20
2017 Jean-Baptiste Fini, Bilal B. Mughal, Sébastien Le Mével, Michelle Leemans, Mélodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A. Demeneix
Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos
published pages: 43786, ISSN: 2045-2322, DOI: 10.1038/srep43786
Scientific Reports 7 2019-11-20
2018 Ali Alavian-Ghavanini, Joëlle Rüegg
Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods
published pages: 38-45, ISSN: 1742-7835, DOI: 10.1111/bcpt.12878
Basic & Clinical Pharmacology & Toxicology 122/1 2019-11-20
2017 M. Hoffmann, S. Gebauer, M. Nüchter, R. Baber, J. Ried, M. von Bergen, W. Kiess
Endokrine Modulatoren
published pages: 640-648, ISSN: 1436-9990, DOI: 10.1007/s00103-017-2551-8
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 60/6 2019-11-20
2017 I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, K Svechnikov
Androgenic potential of human fetal adrenals at the end of the first trimester
published pages: 348-359, ISSN: 2049-3614, DOI: 10.1530/EC-17-0085
Endocrine Connections 6/6 2019-11-20
2017 Miriam N. Jacobs, Emma L. Marczylo, Carlos Guerrero-Bosagna, Joëlle Rüegg
Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals
published pages: 105-160, ISSN: 1543-5938, DOI: 10.1146/annurev-environ-102016-061111
Annual Review of Environment and Resources 42/1 2019-11-20
2016 Roland Solecki, Andreas Kortenkamp, Ã…ke Bergman, Ibrahim Chahoud, Gisela H. Degen, Daniel Dietrich, Helmut Greim, Helen HÃ¥kansson, Ulla Hass, Trine Husoy, Miriam Jacobs, Susan Jobling, Alberto Mantovani, Philip Marx-Stoelting, Aldert Piersma, Vera Ritz, Remy Slama, Ralf Stahlmann, Martin van den Berg, R. Thomas Zoeller, Alan R. Boobis
Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement
published pages: , ISSN: 0340-5761, DOI: 10.1007/s00204-016-1866-9
Archives of Toxicology 2019-11-20
2016 E. Kitraki, I. Nalvarte, A. Alavian-Ghavanini, J. Rüegg
Effects of pre- and post-natal exposure to bisphenol A on the stress system
published pages: e1184775, ISSN: 2327-3747, DOI: 10.1080/23273747.2016.1184775
Endocrine Disruptors 4/1 2019-11-20
2016 Lars Lind, P. Monica Lind, Margareta H. Lejonklou, Linda Dunder, Åke Bergman, Carlos Guerrero-Bosagna, Erik Lampa, Hong Kyu Lee, Juliette Legler, Angel Nadal, Youngmi Kim Pak, Richard P. Phipps, Laura N. Vandenberg, Daniel Zalko, Marlene Ågerstrand, Mattias Öberg, Bruce Blumberg, Jerrold J. Heindel, Linda S. Birnbaum
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic
published pages: , ISSN: 0091-6765, DOI: 10.1289/ehp.1511115
Environmental Health Perspectives 124/5 2019-11-20

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