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OPTIC BIOEM

Toward the comprehension of primary bioelectromagnetic interactions: real time non-linear OPTICal imaging of BIO-samples under ElectroMagnetic exposure

Total Cost €

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EC-Contrib. €

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Partnership

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 OPTIC BIOEM project word cloud

Explore the words cloud of the OPTIC BIOEM project. It provides you a very rough idea of what is the project "OPTIC BIOEM" about.

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Project "OPTIC BIOEM" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://sites.google.com/site/opticbioemmsca/home
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Cell membrane permeabilization, involving its reversible or irreversible restructuring, under extremely short electric (E) pulses exposure (from hundreds of us down to few ns) has a key role in a number of clinical, preclinical, and medical research applications. Hence, the knowledge of its bio-physical nature and dynamics (i.e. formation and resealing processes) is crucial for an aware control of delivered protocols, and for predicting treatments efficacy under established biological (e.g. buffer conductivity, cell dimensions) and electromagnetic (EM) conditions (e.g. pulse duration, amplitude, shape). To understand bio-physical mechanisms underlying such a pulse-exposure permeabilization, an innovative and advantageous approach is proposed based on real-time molecular vibrational modes imaging using fast Coherent anti-Stokes Raman Scattering (CARS) of in vitro samples under such a stimulation. Hence, in the present Marie Sklodowska Curie Action (MSCA), a fast CARS microscope will be integrated with a suitable wide band in vitro electromagnetic field (EMF) exposure setup to study the role of membrane lipid reactions and interfacial water in the electropermeabilization phenomenon. This innovative CARS analysis will be supported by mass spectroscopy measurements to verify the appearance of corresponding chemical species, and by simulated E field and pore density distributions on the bio-samples. This last step is an attempt to correlate sample areas presenting the highest CARS signal intensity with the correspondent E field and pore density distributions. The program that integrates engineering, physics, chemistry and biology will allow a substantial progression in my career and network ability through the work on a completely innovative, multidisciplinary and inter-disciplinary subject in one of the most reputed bioelectric laboratory, where the applications of electropermeabilization in biology and medicine where first developed in Europe and worldwide.

 Publications

year authors and title journal last update
List of publications.
2017 C. Merla, M. Scherman, L.M. Mir, B. Attal-Tretout
A wide field CARS setup for spectroscopy under electropulsation of biological media.
published pages: , ISSN: , DOI:
Abstract Book of the European Conference on Non-linear Optical Spectroscopy ECONOS 2017, April 2-5 Jena Germany (www.econos2017.org) 2019-07-24
2016 A. Azan, M. Scherman, A. Silve, V. Utereiner, C. Merla, O. Piot, B. Attal-Tretout, L.M. Mir
Non-invasive and Label-free Optical Spectroscopy Techniques to Investigate theInteraction between Intense Pulsed Electric Fields and Biological Samples
published pages: , ISSN: , DOI:
Abstract Book of the BioEM 2016 Meeting, 5-10 June Ghent Belgium 2019-07-24
2016 C. Merla, M. Liberti, A. Azan, P. Marracino, F. Apollonio, L. M. Mir
EM Setups for Real Time Optical Imaging under Electromagnetic Exposures.
published pages: , ISSN: , DOI:
Abstract Book of the BioEM 2016 Meeting, 5-10 June Ghent, Belgium 2019-07-24
2017 C. Merla, M. Liberti, P. Marracino, A. Muscat, A. Azan, F. Apollonio, L. M. Mir
A wide bans setup for real-time optical detection of bioelectromagnetic interactions in vitro
published pages: , ISSN: , DOI:
Abstract Book of the BIOEM 2017, June 5-9 Hangzhou China (www.bioem2017.org) 2019-07-24
2016 C. Merla and L.M. Mir
Disseminating the OPTIC BIOEM MSCA-IF Project: the SICEAN Workshop at theBioEM 2016 Meeting
published pages: , ISSN: , DOI:
Abstract Book of the BioEM 2016 Meeting, 5-10 June 2016 2019-07-24
2016 C. Merla, M. Liberti, A. Azan, P. Marracino, F. Apollonio, L. M. Mir
A coplanar waveguide system for cells EM exposure and real time Coherent Anti-Stokes Raman (CARS) imaging
published pages: , ISSN: , DOI:
Abstract Book of the Bioelectrics 2016 13th International Bioelectrics Symposium, September 12-15 Rostock Germany (www.bioelectrics2016.org) 2019-07-24
2016 A. Denzi, M. Casciola, P. Marracino, C. Merla, A. Paffi, M. Liberti, F. Apollonio
Microchambers for Cell Exposure: from the Design to Applications
published pages: , ISSN: , DOI:
Abstract Book of the BioEM 2016 Meeting, 5-10 June Ghent Belgium. 2019-07-24
2017 C. Merla, M. Liberti, A. Ghorbel, P. Marracino, M. Scherman, A. Muscat, A. Azan, F. Apollonio, B. Attal-Tretout, L. M. Mir
A wide-band biochip for real-time non-linear optical detection of bioelectromagnetic interactions with cells and first results
published pages: , ISSN: , DOI:
Abstract Book of the 2nd World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine, and Food and Environmental Technologies September 24-29 Norfolk, VA USA (www.wc2017.electroporation.net) 2019-07-24
2017 C. Merla, M. Scherman, B. Attal-Tretout, L.M. Mir
A wide field CARS setup for spectroscopy under electropulsation of biological objects
published pages: , ISSN: , DOI:
2019-07-24
2017 C. Merla, M. Liberti, P. Marracino, A. Azan, F. Apollonio, L. M. Mir
A setup for cell EM exposure during Coherent Anti-Stokes Raman (CARS) imaging
published pages: , ISSN: , DOI:
Abstract Book of the XXXIInd International Union of Radio Science General Assembly and Scientific Symposium, August 19-26 Montreal Canada (www.ursi2017.org) 2019-07-24
2016 C. Merla
Newsletter of the International Society for Electroporation-Based Technologies and Treatments
published pages: , ISSN: , DOI:
Newsletter of the International Society for Electroporation-Based Technologies and Treatments 2019-07-24
2016 A. Azan, V. Untereiner, C. Merla, C. Gobinet, O. Piot, L. M. Mir
Characterization of Cell Electropermeabilization by Confocal Raman Spectroscopy
published pages: , ISSN: , DOI:
Abstract Book of the BioEM 2016 Meeting, 5-10 June, Ghent Belgium 2019-07-24

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