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OptoVision SIGNED

Optogenetic investigation of cortical layer-6 neuron contributions to dynamic visual perception

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EC-Contrib. €

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Project "OptoVision" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://research.ncl.ac.uk/schmidlab/
 Total cost 1˙405˙000 €
 EC max contribution 1˙405˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 1˙405˙000.00

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 Project objective

In order to achieve a more complete understanding of neocortical brain functions in health and disease, we need to delineate the computations of specific cell populations and how they dynamically exert their impact on connected target neurons. Here, I propose to investigate the functions of neurons in layer-6 of primary visual cortex (V1) and their influence on connected neurons, i) in the lateral geniculate nucleus (LGN) of thalamus, and ii) to more superficially located V1 cells, during visual perception in non-human primates (NHP). My core hypothesis is that due to their unique connectivity with LGN on one hand and layer-4 of V1 on the other hand, layer-6 neurons are in an ideal position to facilitate the transmission of visual information from LGN to V1 when spatial attention is allocated to specific visual targets. The central aim of my investigations will be to delineate how the computations and network interactions of layer-6 neurons dynamically change during attention and ultimately lead to improved behavioral performance. To this end, selective targeting and manipulation of LGN projecting V1 layer-6 neurons will be enabled using the methods of optogenetics (ChR2) and viral delivery techniques. Methods to measure brain activity and assess the impact of optogenetic stimulation will include behavioral assessment, functional magnetic resonance imaging (fMRI) and extra-cellular multi-electrode electrophysiology. Data analysis will include measures of directed (functional and effective) connectivity and en-/decoding approaches using a (predictive coding) Bayesian inference framework. With this approach we will gain new insights into the basic principles of information flow in the visual system. Beyond their immediate impact on basic science, the results of the experiments will be contributing towards a better understanding of the diseased brain such as in schizophrenia or attention-deficit-hyperactivity (ADHD) syndrome.

 Publications

year authors and title journal last update
List of publications.
2016 Katharine A. Shapcott, Joscha T. Schmiedt, Richard C. Saunders, Alexander Maier, David A. Leopold, Michael C. Schmid
Correlated activity of cortical neurons survives extensive removal of feedforward sensory input
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep34886
Scientific Reports 6/1 2019-05-29
2017 Phillipp Kurtz, Katharine A. Shapcott, Jochen Kaiser, Joscha T. Schmiedt, Michael C. Schmid
The Influence of Endogenous and Exogenous Spatial Attention on Decision Confidence
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06715-w
Scientific Reports 7/1 2019-05-29
2018 Ricardo Kienitz, Joscha T. Schmiedt, Katharine A. Shapcott, Kleopatra Kouroupaki, Richard C. Saunders, Michael Christoph Schmid
Theta Rhythmic Neuronal Activity and Reaction Times Arising from Cortical Receptive Field Interactions during Distributed Attention
published pages: 2377-2387.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.05.086
Current Biology 28/15 2019-05-29
2017 Adriana Galvan, William R. Stauffer, Leah Acker, Yasmine El-Shamayleh, Ken-ichi Inoue, Shay Ohayon, Michael C. Schmid
Nonhuman Primate Optogenetics: Recent Advances and Future Directions
published pages: 10894-10903, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1839-17.2017
The Journal of Neuroscience 37/45 2019-05-29
2016 Carsten Klein, Henry C. Evrard, Katharine A. Shapcott, Silke Haverkamp, Nikos K. Logothetis, Michael C. Schmid
Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex
published pages: 143-151, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.02.036
Neuron 90/1 2019-05-29
2017 Rikkert Hindriks, Joscha Schmiedt, Xerxes D. Arsiwalla, Alina Peter, Paul F. M. J. Verschure, Pascal Fries, Michael C. Schmid, Gustavo Deco
Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays
published pages: e0187490, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0187490
PLOS ONE 12/12 2019-05-29
2018 Kacie Dougherty, Michael C. Schmid, Alexander Maier
Binocular response modulation in the lateral geniculate nucleus
published pages: , ISSN: 0021-9967, DOI: 10.1002/cne.24417
Journal of Comparative Neurology 2019-05-29
2018 Michael Ortiz-Rios, Marcus Haag, Fabien Balezeau, Stephen Frey, Alex Thiele, Kathy Murphy, Michael Christoph Schmid
Improved methods for MRI-compatible implants in nonhuman primates
published pages: , ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2018.09.013
Journal of Neuroscience Methods 2019-05-07
2018 Michael P. Milham, Lei Ai, Bonhwang Koo, Ting Xu, Céline Amiez, Fabien Balezeau, Mark G. Baxter, Erwin L.A. Blezer, Thomas Brochier, Aihua Chen, Paula L. Croxson, Christienne G. Damatac, Stanislas Dehaene, Stefan Everling, Damian A. Fair, Lazar Fleysher, Winrich Freiwald, Sean Froudist-Walsh, Timothy D. Griffiths, Carole Guedj, Fadila Hadj-Bouziane, Suliann Ben Hamed, Noam Harel, Bassem Hiba, Bechir Jarraya, Benjamin Jung, Sabine Kastner, P. Christiaan Klink, Sze Chai Kwok, Kevin N. Laland, David A. Leopold, Patrik Lindenfors, Rogier B. Mars, Ravi S. Menon, Adam Messinger, Martine Meunier, Kelvin Mok, John H. Morrison, Jennifer Nacef, Jamie Nagy, Michael Ortiz Rios, Christopher I. Petkov, Mark Pinsk, Colline Poirier, Emmanuel Procyk, Reza Rajimehr, Simon M. Reader, Pieter R. Roelfsema, David A. Rudko, Matthew F.S. Rushworth, Brian E. Russ, Jerome Sallet, Michael Christoph Schmid, Caspar M. Schwiedrzik, Jakob Seidlitz, Julien Sein, Amir Shmuel, Elinor L. Sullivan, Leslie Ungerleider, Alexander Thiele, Orlin S. Todorov, Doris Tsao, Zheng Wang, Charles R.E. Wilson, Essa Yacoub, Frank Q. Ye, Wilbert Zarco, Yong-di Zhou, Daniel S. Margulies, Charles E. Schroeder
An Open Resource for Non-human Primate Imaging
published pages: 61-74.e2, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.08.039
Neuron 100/1 2019-05-07
2018 Samson Chota, Canhuang Luo, Sébastien M. Crouzet, Léa Boyer, Ricardo Kienitz, Michael Christoph Schmid, Rufin VanRullen
Rhythmic fluctuations of saccadic reaction time arising from visual competition
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34252-7
Scientific Reports 8/1 2019-05-07

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