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REPROGRAM SIGNED

Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 REPROGRAM project word cloud

Explore the words cloud of the REPROGRAM project. It provides you a very rough idea of what is the project "REPROGRAM" about.

exhibit    morbidities    chronic    search    immune    trained    patients    reprogramming    mice    ex    guarantees    area    rapid    epigenetic    systemic    perpetuates    co    players    man    learning    immunity    intersectoral    plaque    therapeutic    incapable    rheumatoid    residual    modulation    innovative    societal    arthritis    enforced    relevance    network    additional    discoveries    immunology    prevented    transduced    atherosclerotic    upheld    destabilization    migration    progression    data    consisting    70    attested    extrapolation    compelling    leaders    cell    impacting    inflammation    prove    vivo    oncology    cohorts    translation    huge    cells    vitro    paradigm    eminent    mechanistic    activation    diseases    decreases    burden    strategies    molecule    reprogram    inflammatory    therapies    regimens    events    biology    prospects    shows    up    opinion    shift    disease    innate    interventions    mass    opens    memory    cardiovascular    mechanisms   

Project "REPROGRAM" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://reprogram-horizon2020.eu
 Total cost 6˙000˙000 €
 EC max contribution 5˙250˙000 € (88%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 1˙112˙625.00
2    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 973˙500.00
3    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 925˙000.00
4    THE GENERAL HOSPITAL CORPORATION US (BOSTON MA) participant 600˙000.00
5    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 587˙375.00
6    REGION HOVEDSTADEN DK (HILLEROD) participant 255˙000.00
7    UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA RO (Cluj-Napoca) participant 232˙500.00
8    INSTITUT DE RECHERCHES INTERNATIONALES SERVIER FR (SURESNES) participant 225˙000.00
9    DESCIN BV NL (Vinkeveen) participant 221˙500.00
10    SENSILAB POLSKA SP ZOO - SKA PL (KONSTANTYNOW LODZKI) participant 117˙500.00
11    UNIVERSITAT ZURICH CH (ZURICH) participant 0.00

Map

 Project objective

Up to 70% of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, considered to be incapable of learning ability, does exhibit a memory feature transduced via epigenetic modulation. Compelling evidence shows that atherosclerotic factors promote immune cell migration by pre-activation of innate immune cells. In this project called REPROGRAM, we aim to prove that innate immune cell activation via epigenetic reprogramming perpetuates the upheld systemic inflammatory state in cardiovascular disease which is common in other chronic inflammatory diseases. This opens a new therapeutic area in which epigenetic modulation of innate immune cells effectively decreases systemic inflammation impacting on chronic inflammation as well as the development of co-morbidities. The integrated use of in vitro, ex vivo and in vivo studies, including cells, mice and patients, allows translation from in vitro mechanisms to diseases (molecule-to-man) and extrapolation to cohorts (man-to-mass), enabling us to demonstrate relevance and therapeutic potential of targeting trained immunity in cardiovascular and chronic inflammatory diseases. Enforced by the promising data in oncology, the future prospects for epigenetic interventions in cardiovascular and chronic inflammatory diseases are eminent, attested by the large residual cardiovascular disease burden and the huge societal impact of other chronic inflammatory diseases. The REPROGRAM consortium consisting of key opinion leaders in the field of cardiovascular (systems) biology, immunology, epigenetic therapies and rheumatoid arthritis, with a large intersectoral network, guarantees rapid translation of early mechanistic discoveries

 Deliverables

List of deliverables.
PET/CT studies in patients with active and remissive RA Documents, reports 2020-03-24 11:01:45
24 ldlr-/- experiments using either placebo or epigenetic modulator Documents, reports 2020-03-24 11:01:29
Nanoparticle vs. unpackaged epigenetic modulator in vitro and experimental model Documents, reports 2020-03-24 11:00:59
Ex vivo analysis of monocyte phenotype/function/epigenome in patients with active vs. remissive RA Documents, reports 2020-03-24 11:01:24
Gender-specific analysis addressing distinct patterns in inflammatory activity Documents, reports 2020-03-24 11:01:39
Data on phenotype, function and epigenome of myeloid cells Documents, reports 2020-03-24 11:01:42
Local delivery strategy development for a epigenetic modulator Documents, reports 2020-03-24 11:01:42
Knowledge exploitation final report Documents, reports 2020-03-24 11:01:38
Dissemination final report Documents, reports 2020-03-24 11:01:40
Roadmap for exploitation Documents, reports 2020-02-24 13:41:47
CID-associated DAMPs on human monocyte phenotype/function/epigenome Documents, reports 2020-02-24 13:41:47
In vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells Documents, reports 2020-02-24 13:41:47
Relation between gene-score and cardiovascular risk Documents, reports 2020-02-24 13:41:47
50 BMT experiments in various mouse models Documents, reports 2020-02-24 13:41:47
Epigenetic modulators on in vitro cell systems Documents, reports 2020-02-24 13:41:47
Young researcher training program Documents, reports 2020-02-24 13:41:44
Validated gene score for modified epigenetic modulation Documents, reports 2020-02-24 13:41:44
Quality Assurance File Documents, reports 2020-02-24 13:41:44
Data management plan Documents, reports 2020-02-24 13:41:44

Take a look to the deliverables list in detail:  detailed list of REPROGRAM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Renate M. Hoogeveen, Tjerk S.J. Opstal, Yannick Kaiser, Lotte C.A. Stiekema, Jeffrey Kroon, Remco J.J. Knol, Willem A. Bax, Hein J. Verberne, Jan H. Cornel, Erik S.G. Stroes
PCSK9 Antibody Alirocumab Attenuates Arterial Wall Inflammation Without Changes in Circulating Inflammatory Markers
published pages: 2571-2573, ISSN: 1936-878X, DOI: 10.1016/j.jcmg.2019.06.022
JACC: Cardiovascular Imaging 12/12 2020-03-06
2018 Lotte C A Stiekema, Erik S G Stroes, Simone L Verweij, Helina Kassahun, Lisa Chen, Scott M Wasserman, Marc S Sabatine, Venkatesh Mani, Zahi A Fayad
Persistent arterial wall inflammation in patients with elevated lipoprotein(a) despite strong low-density lipoprotein cholesterol reduction by proprotein convertase subtilisin/kexin type 9 antibody treatment
published pages: 2775-2781, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy862
European Heart Journal 40/33 2020-02-27
2019 Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber
Immunotherapy for cardiovascular disease
published pages: 3937-3946, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehz283
European Heart Journal 40/48 2020-02-24
2018 Manuela Casula, Elena Olmastroni, Angela Pirillo, Alberico Luigi Catapano, Marcello Arca, Maurizio Averna, Stefano Bertolini, Sebastiano Calandra, Alberico Luigi Catapano, Patrizia Tarugi, Fabio Pellegatta, Francesco Angelico, Marcello Arca, Maurizio Averna, Andrea Bartuli, Giacomo Biasucci, Gianni Biolo, Luca Bonanni, Katia Bonomo, Claudio Borghi, Antonio Carlo Bossi, Adriana Branchi, Francesca C
Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study
published pages: 413-418, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.08.013
Atherosclerosis 277 2020-02-24
2019 Menno P.J. de Winther, Esther Lutgens
The Link between Hematopoiesis and Atherosclerosis
published pages: 1869-1871, ISSN: 0028-4793, DOI: 10.1056/nejmcibr1901397
New England Journal of Medicine 380/19 2020-02-24
2019 Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure
published pages: 141-144, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2018.12.076
International Journal of Cardiology 279 2020-02-24
2018 Angela Pirillo, Fabrizia Bonacina, Giuseppe Danilo Norata, Alberico Luigi Catapano
The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis
published pages: , ISSN: 1523-3804, DOI: 10.1007/s11883-018-0715-0
Current Atherosclerosis Reports 20/3 2020-02-24
2018 Frederick J. Raal, G. Kees Hovingh, Alberico L. Catapano
Familial hypercholesterolemia treatments: Guidelines and new therapies
published pages: 483-492, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.06.859
Atherosclerosis 277 2020-02-24
2018 Simone L. Verweij, Lotte C. A. Stiekema, Ronak Delewi, Kang H. Zheng, Sophie J. Bernelot Moens, Jeffrey Kroon, Charlotte I. Stroes, Miranda Versloot, Jan J. Piek, Hein J. Verberne, Erik S. G. Stroes
Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18F-DPA-714 PET/CT
published pages: 1956-1963, ISSN: 1619-7070, DOI: 10.1007/s00259-018-4038-8
European Journal of Nuclear Medicine and Molecular Imaging 45/11 2020-02-24
2018 José Tuñón, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Imo E Hoefer, Daniel F J Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Magnus Bäck
Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology
published pages: 10-19, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy293
Cardiovascular Research 115/1 2020-02-24
2018 Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis
published pages: 944-953, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy092
Cardiovascular Research 114/7 2020-02-24
2018 I. C. L. van den Munckhof, A. Kurilshikov, R. ter Horst, N. P. Riksen, L. A. B. Joosten, A. Zhernakova, J. Fu, S. T. Keating, M. G. Netea, J. de Graaf, J. H. W. Rutten
Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies
published pages: 1719-1734, ISSN: 1467-7881, DOI: 10.1111/obr.12750
Obesity Reviews 19/12 2020-02-24
2018 Niels P. Riksen, Mihai G. Netea
Be aware, innate immune cells remember
published pages: 2218-2219, ISSN: 1945-4589, DOI: 10.18632/aging.101552
Aging 10/9 2020-02-24
2019 Siroon Bekkering, Lotte C.A. Stiekema, Sophie Bernelot Moens, Simone L. Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E. Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S.G. Stroes, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen
Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia
published pages: 1-2, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.05.014
Cell Metabolism 30/1 2020-02-24
2019 J. Plat, S. Baumgartner, T. Vanmierlo, D. Lütjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, A.C.E. Vreugdenhil, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. Mensink
Plant-based sterols and stanols in health & disease: “Consequences of human development in a plant-based environment?”
published pages: 87-102, ISSN: 0163-7827, DOI: 10.1016/j.plipres.2019.02.003
Progress in Lipid Research 74 2020-02-24
2019 Charlotte D C C van der Heijden, Samuel T Keating, Laszlo Groh, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Aldosterone induces trained immunity: the role of fatty acid synthesis
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvz137
Cardiovascular Research 2020-02-24
2018 Laszlo Groh, Mihai G Netea, Niels P Riksen, Samuel T Keating
Getting to the marrow of trained immunity
published pages: 1151-1154, ISSN: 1750-1911, DOI: 10.2217/epi-2018-0098
Epigenomics 10/9 2020-02-24
2019 Julia van Tuijl, Leo A B Joosten, Mihai G Netea, Siroon Bekkering, Niels P Riksen
Immunometabolism orchestrates training of innate immunity in atherosclerosis
published pages: 1416-1424, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz107
Cardiovascular Research 115/9 2020-02-24
2018 Niels P. Riksen, Rinke Stienstra
Metabolism of innate immune cells
published pages: 359-367, ISSN: 0957-9672, DOI: 10.1097/mol.0000000000000539
Current Opinion in Lipidology 29/5 2020-02-24
2019 Niels P. Riksen
Trained immunity and atherosclerotic cardiovascular disease
published pages: 395-400, ISSN: 0957-9672, DOI: 10.1097/mol.0000000000000628
Current Opinion in Lipidology 30/5 2020-02-24
2019 Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00791
Frontiers in Immunology 10 2020-02-24
2019 Fangfang Sun, Irene Abreu-Rodriguez, Shuang Ye, Steffen Gay, Oliver Distler, Michel Neidhart, Emmanuel Karouzakis
TET1 is an important transcriptional activator of TNFα expression in macrophages
published pages: e0218551, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218551
PLOS ONE 14/6 2020-02-24
2018 Siroon Bekkering, Rob J.W. Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D.C.C. van der Heijden, Yang Li, Calin D. Popa, Rob ter Horst, Julia van Tuijl, Romana T. Netea-Maier, Frank L. van de Veerdonk, Triantafyllos Chavakis, Leo A.B. Joosten, Jos W.M. van der Meer, Henk Stunnenberg, Niels P. Riksen, Mihai G. Netea
Metabolic Induction of Trained Immunity through the Mevalonate Pathway
published pages: 135-146.e9, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.11.025
Cell 172/1-2 2020-02-24
2017 Charlotte D.C.C. van der Heijden, Marlies P. Noz, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen, Samuel T. Keating
Epigenetics and Trained Immunity
published pages: , ISSN: 1523-0864, DOI: 10.1089/ars.2017.7310
Antioxidants & Redox Signaling 2020-02-24
2017 Johan G. Schnitzler, Sophie J. Bernelot Moens, Feiko Tiessens, Guido J. Bakker, Geesje M. Dallinga-Thie, Albert K. Groen, Max Nieuwdorp, Erik S. G. Stroes, Jeffrey Kroon
Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy
published pages: 2210-2219, ISSN: 0022-2275, DOI: 10.1194/jlr.D073197
Journal of Lipid Research 58/11 2020-02-24
2017 Sophie J. Bernelot Moens, Annette E. Neele, Jeffrey Kroon, Fleur M. van der Valk, Jan Van den Bossche, Marten A. Hoeksema, Renate M. Hoogeveen, Johan G. Schnitzler, Marie T. Baccara-Dinet, Garen Manvelian, Menno P.J. de Winther, Erik S.G. Stroes
PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia
published pages: 1584-1593, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx002
European Heart Journal 38/20 2020-02-24
2018 Anette Christ, Patrick Günther, Mario A.R. Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J. Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J.C.F.M. Moorlag, Vinod Kumar, Min Hi Park, Leo A.B. Joosten, Laszlo A. Groh, Niels P. Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L. Fitzgerald, Mihai G. Net
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
published pages: 162-175.e14, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.12.013
Cell 172/1-2 2020-02-24
2018 Jenneke Leentjens, Siroon Bekkering, Leo A Joosten, Mihai G Netea, David P Burgner, Niels P Riksen
Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis
published pages: CIRCRESAHA.117.3, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.312465
Circulation Research 2018 Jan 24 2020-02-24
2018 Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Monocyte and macrophage immunometabolism in atherosclerosis
published pages: 203-214, ISSN: 1863-2297, DOI: 10.1007/s00281-017-0656-7
Seminars in Immunopathology 40/2 2020-02-24
2017 Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Exploring immune checkpoints as potential therapeutic targets in atherosclerosis
published pages: 368-377, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx248
Cardiovascular Research 114/3 2020-02-24
2018 Samuel T. Keating, Janna A. van Diepen, Niels P. Riksen, Assam El-Osta
Epigenetics in diabetic nephropathy, immunity and metabolism
published pages: 6-20, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4490-1
Diabetologia 61/1 2020-02-24
2017 Simone L Verweij, Raphaël Duivenvoorden, Lotte C A Stiekema, Nick S Nurmohamed, Fleur M van der Valk, Miranda Versloot, Hein J Verberne, Erik S G Stroes, Matthias Nahrendorf, Siroon Bekkering, Sophie J Bernelot Moens
CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease
published pages: 468-475, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx224
Cardiovascular Research 114/3 2020-02-24
2017 Sophie J. Bernelot Moens, Simone L. Verweij, Johan G. Schnitzler, Lotte C.A. Stiekema, Merijn Bos, Anne Langsted, Carlijn Kuijk, Siroon Bekkering, Carlijn Voermans, Hein J. Verberne, Børge G. Nordestgaard, Erik S.G. Stroes, Jeffrey Kroon
Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in HumansHighlights
published pages: 969-975, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.116.308834
Arteriosclerosis, Thrombosis, and Vascular Biology 37/5 2020-02-24
2018 Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
published pages: 527-542, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.11.055
Journal of the American College of Cardiology 71/5 2020-02-24
2017 Lotte C.A. Stiekema, Johan G. Schnitzler, Matthias Nahrendorf, Erik S.G. Stroes
The maturation of a ‘neural–hematopoietic’ inflammatory axis in cardiovascular disease
published pages: 507-512, ISSN: 0957-9672, DOI: 10.1097/MOL.0000000000000457
Current Opinion in Lipidology 28/6 2020-02-24
2017 Renate M Hoogeveen, Matthias Nahrendorf, Niels P Riksen, Mihai G Netea, Menno P J de Winther, Esther Lutgens, Børge G Nordestgaard, Michel Neidhart, Erik S G Stroes, Alberico L Catapano, Siroon Bekkering
Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases
published pages: , ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx581
European Heart Journal 2020-02-24
2018 Vanessa Frodermann, Matthias Nahrendorf
Macrophages and Cardiovascular Health
published pages: 2523-2569, ISSN: 0031-9333, DOI: 10.1152/physrev.00068.2017
Physiological Reviews 98/4 2020-02-24
2018 Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory Wojtkiewicz, Lisa Honold, Friedrich Felix Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny Herisson, Yookyung Jung, Pauline A. Désogère, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E. Sosnovik, Charles P. Lin, Filip K. Swirski, Matthias Nahrendorf
Imaging the Vascular Bone Marrow Niche During Inflammatory Stress
published pages: 415-427, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.313302
Circulation Research 123/4 2020-02-24
2018 Ellen Rouwet, Esther Lutgens
2016 Jeffrey M. Hoeg Award Lecture
published pages: 1678-1688, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.307742
Arteriosclerosis, Thrombosis, and Vascular Biology 38/8 2020-02-24
2018 Matthias Nahrendorf
Myeloid cell contributions to cardiovascular health and disease
published pages: 711-720, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0064-0
Nature Medicine 24/6 2020-02-24
2018 Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
CD40L Deficiency Protects Against Aneurysm Formation
published pages: 1076-1085, ISSN: 1079-5642, DOI: 10.1161/atvbaha.117.310640
Arteriosclerosis, Thrombosis, and Vascular Biology 38/5 2020-02-24
2017 Alberico Catapano, Angela Pirillo, Giuseppe Danilo Norata
Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives
published pages: 343-351, ISSN: 1178-2048, DOI: 10.2147/VHRM.S130338
Vascular Health and Risk Management Volume 13 2020-02-24
2018 Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi, Andrea Baragetti, Annalisa Moregola, Katia Garlaschelli, Patrizia Uboldi, Fabio Pellegatta, Liliana Grigore, Lorenzo Da Dalt, Andrea Annoni, Silvia Gregori, Qingzhong Xiao, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Federica M. Marelli-Berg, Giuseppe D. Norata
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05322-1
Nature Communications 9/1 2020-02-24
2018 Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology
published pages: 1411-1421, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy184
Cardiovascular Research 114/11 2020-02-24
2018 Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction
published pages: e0202150, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0202150
PLOS ONE 13/8 2020-02-24
2018 Annette E. Neele, Marion J.J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C.S. Boshuizen, Koen H.M. Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P.P.A. van Roomen, Annelie Shami, Johannes H.M. Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P.J. de Winther
Myeloid Kdm6b deficiency results in advanced atherosclerosis
published pages: 156-165, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.05.052
Atherosclerosis 275 2020-02-24

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