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Tools and TECHNOlogies for Breakthrough in hEArt Therapies

Total Cost €


EC-Contrib. €






 TECHNOBEAT project word cloud

Explore the words cloud of the TECHNOBEAT project. It provides you a very rough idea of what is the project "TECHNOBEAT" about.

vivo    global    burden    ideally    medical    ipsc    gmp    compliant    cardiomyocytes    pericytes    contrast    repair    functional    monitoring    bone    option    source    therapies    transplantation    hearts    differentiation    line    interdisciplinary    types    attractive    cells    human    cell    industry    economic    pluripotent    micro    suffering    bioreactor    myocardial    entails    muscle    connective    unlimited    reprogramming    benefit    bioprocess    somatic    hipsc    endothelial    hub    forming    grafts    irreversible    innovative    attractiveness    physiologically    lacking    preclinical    expandability    socio    academia    damaged    ultimate    cellular    standards    cardiac    infarction    clinicians    translation    options    adult    marrow    technobeat    tools    tissue    reasonable    technologies    cardiovascular    blood    stage    clinical    reconstitution    constitute    therapeutic    integration    diseases    stem    longitudinal    healthcare    progenies    universal    positioned    patients    bioprocessing    safety    excellence    organ    mi    hipscs    engineers    treatment    models    regulatory    proof    heart   

Project "TECHNOBEAT" data sheet

The following table provides information about the project.


Organization address
address: Carl-Neuberg-Strasse 1
postcode: 30625

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 5˙968˙850 €
 EC max contribution 5˙968˙850 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
4    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 650˙000.00
5    KADIMASTEM LTD IL (NES ZIONA) participant 649˙950.00
6    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 649˙750.00
7    OVIZIO IMAGING SYSTEMS BE (BRUXELLES) participant 649˙375.00


 Project objective

Cardiovascular diseases including myocardial infarction (MI), which entails the irreversible loss of heart muscle tissue, constitute a major socio-economic burden in global healthcare. With whole organ transplantation as the only treatment option for end-stage heart failure, MI patients could particularly benefit from advanced cell therapies aimed at the functional reconstitution of damaged hearts. Human induced pluripotent stem cells (hiPSCs) can be derived by reprogramming patients’ somatic cells. In contrast to adult (stem) cells e.g. from blood, bone marrow or the heart, hiPSCs have unlimited expandability and differentiation potential into all relevant cell types including cardiomyocytes, endothelial cells, pericytes and connective tissue-forming cells, making them highly attractive as a universal cell source for organ repair. However, technologies for the robust therapeutic scale production of hiPSC-derived progenies in line with GMP standards and at reasonable cost are currently lacking. TECHNOBEAT’s ultimate objectives are 1) to advance therapeutic scale cell production through innovative bioreactor technologies and novel cell monitoring tools, and 2) to develop regulatory compliant bioprocessing of innovative iPSC-based cardiac µ-tissue. The clinical translation of cardiac µ-tissue will require 3) the development and application of tools for improved cell delivery and longitudinal in vivo monitoring of cell grafts, and 4) proof-of-concept for safety and functional integration in physiologically relevant preclinical models of cellular heart repair. Through its interdisciplinary excellence, TECHNOBEAT’s consortium of leading European stem cell researchers, clinicians, tissue-, bioprocess-, and technical- engineers in industry and academia is ideally positioned to address these ambitious objectives. It will provide new treatment options for suffering patients and increase Europe’s attractiveness as a hub for innovative medical technologies.


List of deliverables.
Draft and disseminate press release on project initiation Websites, patent fillings, videos etc. 2019-05-30 11:39:30
Website launched, central data base accessible to all partners Websites, patent fillings, videos etc. 2019-05-30 11:39:30

Take a look to the deliverables list in detail:  detailed list of TECHNOBEAT deliverables.


year authors and title journal last update
List of publications.
2017 Verena Schwach, Arie O. Verkerk, Mervyn Mol, Jantine J. Monshouwer-Kloots, Harsha D. Devalla, Valeria V. Orlova, Konstantinos Anastassiadis, Christine L. Mummery, Richard P. Davis, Robert Passier
A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes
published pages: 1765-1779, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2017.10.024
Stem Cell Reports 9/6 2020-03-24
2018 Oleh V. Halaidych, Francijna van den Hil, Christine L. Mummery, Valeria V. Orlova
Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived Endothelial Cells (hiPSC-ECs)
published pages: , ISSN: 1940-087X, DOI: 10.3791/58678
Journal of Visualized Experiments 141 2020-03-24
2019 Anais Sahabian, Malte Sgodda, Ortwin Naujok, Rabea Dettmer, Julia Dahlmann, Felix Manstein, Tobias Cantz, Robert Zweigerdt, Ulrich Martin, Ruth Olmer
Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential
published pages: 1571, ISSN: 2073-4409, DOI: 10.3390/cells8121571
Cells 8/12 2020-03-24
2019 Xu Cao, Gopala K. Yakala, Francijna E. van den Hil, Amy Cochrane, Christine L. Mummery, Valeria V. Orlova
Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives
published pages: 1282-1297, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.05.003
Stem Cell Reports 12/6 2020-03-24
2019 Oleh V. Halaidych, Amy Cochrane, Francijna E. van den Hil, Christine L. Mummery, Valeria V. Orlova
Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells
published pages: 647-656, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.02.003
Stem Cell Reports 12/4 2020-03-24
2019 Amy Cochrane, Hugo J. Albers, Robert Passier, Christine L. Mummery, Albert van den Berg, Valeria V. Orlova, Andries D. van der Meer
Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
published pages: 68-77, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.06.007
Advanced Drug Delivery Reviews 140 2020-03-24
2019 Mees N. S. de Graaf, Amy Cochrane, Francijna E. van den Hil, Wesley Buijsman, Andries D. van der Meer, Albert van den Berg, Christine L. Mummery, Valeria V. Orlova
Scalable microphysiological system to model three-dimensional blood vessels
published pages: 26105, ISSN: 2473-2877, DOI: 10.1063/1.5090986
APL Bioengineering 3/2 2020-03-24
2019 Oleh V. Halaidych, Christine L. Mummery, Valeria V. Orlova
Quantifying Ca2+ signaling and contraction in vascular pericytes and smooth muscle cells
published pages: 112-118, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2019.03.143
Biochemical and Biophysical Research Communications 513/1 2020-03-24
2019 Alexandra Haase, Wolfgang Glienke, Lena Engels, Gudrun Göhring, Ruth Esser, Lubomir Arseniev, Ulrich Martin
GMP-compatible manufacturing of three iPS cell lines from human peripheral blood
published pages: 101394, ISSN: 1873-5061, DOI: 10.1016/j.scr.2019.101394
Stem Cell Research 35 2020-03-24
2019 Gesa L. Tiemeier, Gangqi Wang, Sébastien J. Dumas, Wendy M.P.J. Sol, M. Cristina Avramut, Tobias Karakach, Valeria V. Orlova, Cathelijne W. van den Berg, Christine L. Mummery, Peter Carmeliet, Bernard M. van den Berg, Ton J. Rabelink
Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation
published pages: 803-816, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.10.005
Stem Cell Reports 13/5 2020-03-24
2018 Gesa-Maria Gieseler, Kimia Ekramzadeh, Volker Nölle, Svitlana Malysheva, Henning Kempf, Sascha Beutel, Robert Zweigerdt, Ulrich Martin, Ursula Rinas, Thomas Scheper, Iliyana Pepelanova
Solubilization and renaturation of biologically active human bone morphogenetic protein-4 from inclusion bodies
published pages: e00249, ISSN: 2215-017X, DOI: 10.1016/j.btre.2018.e00249
Biotechnology Reports 18 2019-04-30
2018 Jonas Christoffersson, Florian Meier, Henning Kempf, Kristin Schwanke, Michelle Coffee, Mario Beilmann, Robert Zweigerdt, Carl-Fredrik Mandenius
A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device
published pages: 36, ISSN: 2306-5354, DOI: 10.3390/bioengineering5020036
Bioengineering 5/2 2019-04-30
2017 Medicine Maker/Stephanie Sutton, Katharina Kinast, Ulrike Becken, Robert Zweigerdt
Listen to the Heartbeat
published pages: , ISSN: , DOI:
2018 Mania Ackermann, Henning Kempf, Miriam Hetzel, Christina Hesse, Anna Rafiei Hashtchin, Kerstin Brinkert, Juliane Wilhelmine Schott, Kathrin Haake, Mark Philipp Kühnel, Silke Glage, Constanca Figueiredo, Danny Jonigk, Katherina Sewald, Axel Schambach, Sabine Wronski, Thomas Moritz, Ulrich Martin, Robert Zweigerdt, Antje Munder, Nico Lachmann
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07570-7
Nature Communications 9/1 2019-04-30
2018 Oleh V. Halaidych, Christian Freund, Francijna van den Hil, Daniela C.F. Salvatori, Mara Riminucci, Christine L. Mummery, Valeria V. Orlova
Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells
published pages: 1642-1656, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.012
Stem Cell Reports 10/5 2019-04-30
2019 Rosalinda Madonna, Linda W Van Laake, Hans Erik Botker, Sean M Davidson, Raffaele De Caterina, Felix B Engel, Thomas Eschenhagen, Francesco Fernandez-Aviles, Derek J Hausenloy, Jean-Sebastien Hulot, Sandrine Lecour, Jonathan Leor, Philippe Menasché, Maurizio Pesce, Cinzia Perrino, Fabrice Prunier, Sophie Van Linthout, Kirsti Ytrehus, Wolfram-Hubertus Zimmermann, Peter Ferdinandy, Joost P G Sluijter
ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvz010
Cardiovascular Research 2019-04-30
2018 LABO
Internationale Experten beim zweiten Stem Cell Community DAy
published pages: , ISSN: , DOI:
LABO 7-8/2018 2019-04-30
2018 Cell gene Therapy Insights & DASGIP, Philip Nold
A question of consistency: biopharma know-how meets bioreactor innovation in upstream bioprocessing
published pages: , ISSN: , DOI:
Cell Gene Therapy Insights 2019-04-30
2018 Bogdan Iorga, Kristin Schwanke, Natalie Weber, Meike Wendland, Stephan Greten, Birgit Piep, Cristobal G. dos Remedios, Ulrich Martin, Robert Zweigerdt, Theresia Kraft, Bernhard Brenner
Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.01111
Frontiers in Physiology 8 2019-04-30
2018 Natali Froese, Honghui Wang, Carolin Zwadlo, Yong Wang, Andrea Grund, Anna Gigina, Melanie Hofmann, Katja Kilian, Gesine Scharf, Mortimer Korf-Klingebiel, Anna Melchert, Maria Elena Ricci Signorini, Caroline Halloin, Robert Zweigerdt, Ulrich Martin, Ina Gruh, Kai C. Wollert, Robert Geffers, Johann Bauersachs, Joerg Heineke
Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice
published pages: 114-124, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.08.011
Journal of Molecular and Cellular Cardiology 122 2019-04-30
2018 Erika Gaspari, Annika Franke, Diana Robles-Diaz, Robert Zweigerdt, Ingo Roeder, Thomas Zerjatke, Henning Kempf
Paracrine mechanisms in early differentiation of human pluripotent stem cells: Insights from a mathematical model
published pages: 1-7, ISSN: 1873-5061, DOI: 10.1016/j.scr.2018.07.025
Stem Cell Research 32 2019-04-30
2018 Drug Target Review & DASGIP, Philip Nold
Expert View: Large-scale stem cell expansion and differentiation
published pages: , ISSN: , DOI:
Drug Target Review 2019-04-30
2017 Juan Antonio Guadix, Valeria V. Orlova, Elisa Giacomelli, Milena Bellin, Marcelo C. Ribeiro, Christine L. Mummery, José M. Pérez-Pomares, Robert Passier
Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells
published pages: 1754-1764, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2017.10.023
Stem Cell Reports 9/6 2019-04-30
2018 Dorothee Eicke, Anja Baigger, Kai Schulze, Sharissa L. Latham, Caroline Halloin, Robert Zweigerdt, Carlos A. Guzman, Rainer Blasczyk, Constança Figueiredo
Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28459-x
Scientific Reports 8/1 2019-04-30
2018 Lothar Koch, Andrea Deiwick, Annika Franke, Kristin Schwanke, Axel Haverich, Robert Zweigerdt, Boris Chichkov
Laser bioprinting of human induced pluripotent stem cells—the effect of printing and biomaterials on cell survival, pluripotency, and differentiation
published pages: 35005, ISSN: 1758-5090, DOI: 10.1088/1758-5090/aab981
Biofabrication 10/3 2019-04-30
2018 Kyriakides, O., Halliwell, J., Andrews, P.
Engineering and applicaions of pluripotent stem cells - Acquired genetic and epigenetic varaition in human pluripotent stem cells
published pages: , ISSN: , DOI:
2018 Sarah Hochmann, Michaela Mittermeir, Radmila Santic, Frieder Koszik, Lanay Griessner, Alina Sarah Sonderegger, Thomas Hoffmann, Elisabeth Russe, Sandra Scheiblhofer, Richard Weiss, Markus Mandler, Achim Schneeberger, Dirk Strunk
Evaluation of modified Interferon alpha mRNA constructs for the treatment of non-melanoma skin cancer
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31061-w
Scientific Reports 8/1 2019-04-30
2018 Ramona Weist, Thilo Flörkemeier, Yvonne Roger, Sandra Noack, Annika Franke, Kristin Schwanke, Robert Zweigerdt, Ulrich Martin, Elmar Willbold, Andrea Hoffmann
Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells
published pages: 166-183, ISSN: 1547-3287, DOI: 10.1089/scd.2017.0162
Stem Cells and Development 27/3 2019-04-30
2018 Hanna Wolling, Sarah A. Konze, Anne Höfer, Jelena Erdmann, Andreas Pich, Robert Zweigerdt, Falk F. R. Buettner
Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis
published pages: 1800102, ISSN: 1615-9853, DOI: 10.1002/pmic.201800102
PROTEOMICS 18/14 2019-04-30
2017 Medicine Maker/Stephanie Sutton, Katharina Kinast, Ulrike Becken, Robert Zweigerdt
Collaboration is key
published pages: , ISSN: , DOI:
The Medicine Maker’s Advancing Medicine supplement (print) 2019-04-30
2018 Ruth Olmer, Lena Engels, Abdulai Usman, Sandra Menke, Muhammad Nasir Hayat Malik, Frank Pessler, Gudrun Göhring, Dorothee Bornhorst, Svenja Bolten, Salim Abdelilah-Seyfried, Thomas Scheper, Henning Kempf, Robert Zweigerdt, Ulrich Martin
Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture
published pages: 1657-1672, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.03.017
Stem Cell Reports 10/5 2019-04-30
2017 Ulrike Becken/ DASGIP
\"Editorial \"\"Controlled Stem Cell Production\"\"\"
published pages: , ISSN: , DOI:
Eppendorf Customer Magazine BioNews, H2/2017  2019-04-30
2018 Alain van Mil, Geerthe Margriet Balk, Klaus Neef, Jan Willem Buikema, Folkert W Asselbergs, Sean M Wu, Pieter A Doevendans, Joost P G Sluijter
Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy208
Cardiovascular Research 2019-04-30
2018 Allison TF, Andrews PW, Avior Y, Barbaric I, Benvenisty N, Bock C, Brehm J, Brüstle O, Damjanov I, Elefanty A, Felkner D, Gokhale PJ, Halbritter F, Healy LE, Hu TX, Knowles BB, Loring JF, Ludwig TE, Mayberry R, Micallef S, Mohamed JS, Müller FJ, Mummery CL, Nakatsuji N, Ng ES, Oh SKW, O\'Shea O, Pera MF, Reubinoff B, Robson P, Rossant J, Schuldt BM, Solter D, Sourris K, Stacey G, Stanley EG, Suemori H, Takahashi K, Yamanaka S.
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04011-3
Nature Communications 9/1 2019-04-30
2018 Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk
Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells
published pages: 1421-1434, ISSN: 1838-7640, DOI: 10.7150/thno.21906
Theranostics 8/5 2019-04-30
2018 Christoph Lipps, Franziska Klein, Tom Wahlicht, Virginia Seiffert, Milada Butueva, Jeannette Zauers, Theresa Truschel, Martin Luckner, Mario Köster, Roderick MacLeod, Jörn Pezoldt, Jochen Hühn, Qinggong Yuan, Peter Paul Müller, Henning Kempf, Robert Zweigerdt, Oliver Dittrich-Breiholz, Thomas Pufe, Rainer Beckmann, Wolf Drescher, Jose Riancho, Carolina Sañudo, Thomas Korff, Bertram Opalka, Vera Rebmann, Joachim R. Göthert, Paula M. Alves, Michael Ott, Roland Schucht, Hansjörg Hauser, Dagmar Wirth, Tobias May
Expansion of functional personalized cells with specific transgene combinations
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03408-4
Nature Communications 9/1 2019-04-30
2018 Miguel Castilho, Alain van Mil, Malachy Maher, Corina H. G. Metz, Gernot Hochleitner, Jürgen Groll, Pieter A. Doevendans, Keita Ito, Joost P. G. Sluijter, Jos Malda
Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation
published pages: 1803151, ISSN: 1616-301X, DOI: 10.1002/adfm.201803151
Advanced Functional Materials 28/40 2019-04-30

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The information about "TECHNOBEAT" are provided by the European Opendata Portal: CORDIS opendata.

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